Tulobuterol

Tulobuterol HCL, a bronchodilator, is used as a prevention drug for reversible obstructive air way disease. Tulobuterol is usually shown in conditions like asthma, bronchospasm, chronic bronchitis and emphysema. Tulobuterol blocks the formation of leukotriene which in turn decreases the symptoms of asthma.

Possible side effects of Tulobuterol include hypertension, angina and CNS stimulation. Some of the severe side effects are headache, vomiting, palpitation, insomnia and Vertigo. Some side effects may happen very rarely but are serious. Therefore, it is best to consult your doctor or health care provider if you observe any of these side effects. Patients suffering from diabetes mellitus, hypertension and hyperthyroidism should be very cautious before using this medicine. Consult your doctor or health care professional before using this medicine if you are a cardiac patient.

Inform your doctor or health care professional about your current medications before using Tulobuterol. Do not take this medicine if you are allergic to it. Also, tell your doctor if you have any allergies or diseases before using this medicine as it may worsen your health condition. Consult your doctor if you are pregnant, planning to be pregnant or breastfeeding.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Pulmonologist before using this medicine.

One-Month Inhalation Toxicity Study of Tulobuterol Hydrochloride in Rats and Dogs

Tulobuterol HCL hydrochloride (HCl) has β2-adrenergic agonist activity and is under development for use in the treatment of chronic obstructive lung disease. The purpose of this study was to determine the toxicity of inhaled tulobuterol HCl in rats and dogs. Rats were whole-body exposed to aerosol gravimetric concentrations of 0, 0.03, 0.22, or 1.1 mg/ liter of tulobuterol HCl, 60 min/day for 28 days. Dogs were exposed (via insufflation) to estimated daily doses of 0, 0.2, 1.0, or 6.0 mg/kg for an equal period. Plasma levels of tulobuterol were determined following exposure on Days 1, 8, and 28 using a high-pressure liquid chromato-graphic method developed for this study. Results indicated that plasma tulobuterol levels were highly correlated with tulobuterol doses (p < 0.0001 for rats and dogs). No dose-related changes in body weight food consumption, hematological, or serum chemistry parameters were observed in either species. Anterior nasal cavity lesions were observed by light microscopy in rats exposed to 0.22 and 1.1 mg/liter tulobuterol HCl at an incidence of 14 and 93%, respectively. These lesions involved the nasal septum, turbinates, and/or the dorsolateral wall of the nasal cavity and consisted of suppurative rhinitis and necrosis. The corresponding mean plasma tulobuterol levels on Day 28 in mid- and high-dose rats were approximately 1000 and 15,000 ng/ml. Nasal lesions were not observed in rats allowed to recover for 2 weeks. No gross or microscopic lesions were detected in lungs or other tissues of either species. These results indicate that the insufflation of high doses of tulobuterol HCl aerosol for 1 month was generally without toxicity in dogs and that the local nasal ussue injury observed in rats exposed to high concentrations of aerosolized tulobuterol HCl was reversible.

Raw Tadalafil (Cialis) powder (171596-29-5) Description

Cialis powder, sold under the brand name Cialis powder among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension. It is a tablet taken by mouth. Onset is typically within half an hour and the duration is up to 36 hours.

Tadalafil powder, also known as IC351, is PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis powder, and under the name Adcirca for the treatment of pulmonary arterial hypertension.

Penile erection occurs when the penis fills with blood. This happens because the blood vessels that bring blood flow to the penis dilate, increasing the blood supply. At the same time, the blood vessels that remove blood from the penis contract. The blood accumulates in the penis, causing an erection.

When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP, which controls the dilation and contraction of the blood vessels that carry blood to and from the penis.

Another substance, PDE5, destroys cGMP. When this occurs, the blood vessels return to their normal size, and the erection ends. Tadalafil powder stops PDE5 from destroying cGMP. This causes the erection to last for longer.

The muscles of the arteries in the walls of the lungs also contain PDE5, which is why the same drug can also help with pulmonary hypertension treatment.

Quick Details
ProName: Cialis powder / Cialis Male Sex Enhance Po.
CasNo: 171596-29-5
Molecular Formula: C22H19N3O4
Appearance: White powder
Application: medical intermediate
DeliveryTime: within a week
PackAge: A variety of packing ways for your cho.
Port: Wuhan / Shanghai / Guangzhou ...
ProductionCapacity: 200 Kilogram/Month
Purity: 99.5%min
Storage: Kept in a well-closed, light-resistant.
Transportation: EMS, HKEMS, DHL, TNT, UPS, Fedex.
LimitNum: 10 Gram
Moisture Content: 0%
Impurity: 0.05%
Water content: 0%
Product Description
Nitrates drugs - clinical pharmacology studies have shown that Tadalafil Tablets can enhance the antihypertensive effect of nitrates drugs, so people who are taking any form of organic nitrate drugs are strictly prohibited from taking Tadalafil Tablets. For patients taking Tadalafil Tablets, nitrate drugs are considered only in the treatment of life - threatening conditions, or at least 48 hours after the last dose of Tadalafil Tablets should be considered. Even in this case, nitrate drugs can be given only under strict medical monitoring and appropriate hemodynamic tests (see "taboo", "usage" and "pharmacological toxicology").

Alpha blockers - when PDE5 inhibitors are combined with alpha blockers, should be cautious. PDE5 inhibitors, including Tadalafil Tablets and alpha adrenergic receptor blockers, are vasodilator agents that reduce blood pressure. When vasodilator is used together, it may have a superposition effect on blood pressure. The clinical pharmacology of dalazine combined with doxazosin or tamoxine was studied (see "notice", "usage" and "pharmacological toxicology").

An antihypertensive drug, PDE5 inhibitor, including TEDA, is a mild systemic vasodilator. To assess the effect of diaralan on antihypertensive effects of specific antihypertensive drugs (amiodarone, angiotensin II receptor blocker, benzyl fluorothiazide, enalapril and metoprolol), clinical pharmacology was conducted. After being combined with these drugs, blood pressure was slightly lower than placebo (see "precautions" and "pharmacology and toxicology")

The stability of an extemporaneously prepared tadalafil oral suspension was studied. An oral suspension of tadalafil 5 mg/mL was prepared by thoroughly grinding 15 20-mg Cialis powder in a glass mortar. Thirty milliliters of Ora-Plus and 30 mL of Ora-Sweet were mixed and added to the powder to make a final volume of 60 mL. Three identical samples of the formulation were prepared and placed in 2-oz amber plastic bottles with child-resistant caps and stored at room temperature (23-25 °C). A 1-mL sample was withdrawn from each of the three bottles with a micropipette immediately after preparation and at 7, 14, 28, 57, and 91 days. After double dilution (1:10 and 0.1:5 v/v) to an expected concentration of 10 μg/mL with methanol and mobile phase, respectively, the samples were assayed in duplicate using stability-indicating high-performance liquid chromatography. The samples were visually examined for any color change and evaluated for pH changes on each day of analysis. Taste evaluation was performed at the beginning and end of the study. Stability was defined as the retention of at least 90% of the initial concentration. At least 99% of the initial tadalafil concentration remained throughout the 91-day study period. There were no detectable changes in color, odor, taste, and pH, and no visible microbial growth was observed in any sample. An extemporaneously prepared suspension of tadalafil 5 mg/mL in a 1:1 mixture of Ora-Plus and Ora-Sweet was stable for at least 91 days when stored in amber plastic bottles at room temperature.

A generic version of Cialis® (Eli Lilly) tadalafil tablets (2.5 mg, 5 mg, 10 mg, 20 mg) for the United States market has been annouced by Teva Pharmaceuticals, in a first-to-file launch.

Tadalafil powder are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), and both ED and the signs and symptoms of BPH (ED/BPH). Tadalafil tablets are recommended for use up to 26 weeks when combined with finasteride to initiate BPH treatment.

“We’re proud to offer an affordable treatment option for the estimated 30 million men affected by ED, many of whom will also have symptomatic BPH which is estimated to affect 15 million men in the United States,” said Hafrun Fridriksdottir, EVP and Head of Global R&D for Teva, in a prepared statement.

The most common adverse reactions reported in clinical trials (≥ 2%) for tadalafil were headache, flushing, dyspepsia, nasal congestion, back pain, myalgia, pain in limb, naspharyngitis, upper respiratory tract infection, cough, diarrhea, urinary tract infection, gastroesophageal reflux disease, abdominal pain, gastroenteritis, and hypertension.

Tadalafil tablets are contraindicated in patients using any form of organic nitrate; and in patients with a known serious hypersensitivity to tadalafil. Furthermore, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.

Brendan O’Grady, EVP and Head of North America Commercial at Teva, noted that the launch of the generic tadalafil tablets builds on the company’s exclusive launch of a generic version of Viagra® (sildenafil) tablets last year. “We’re committed to ensuring that patients are able to access this medicine,” O’Grady said, in a prepared statement.

Adamis Pharmaceuticals Corporation (NASDAQ: ADMP) today announced that it has received a Refusal to File letter from the United States Food and Drug Administration (FDA) regarding its New Drug Application (NDA) for its sublingual Tadalafil powder product. As previously announced, on December 28th, 2018, Adamis submitted an NDA for fast-disintegrating sublingual tadalafil (APC-8000) with the FDA for the treatment of erectile dysfunction (ED).

Upon its preliminary review, the FDA determined that the submitted NDA was not sufficiently complete to permit a substantive review. The FDA requested that Adamis supplement and include in a resubmitted NDA (i) longer real-time (versus accelerated) stability data and (ii) additional dissolution data for both the clinical and registration batches. Adamis may seek immediate guidance from the FDA, including requesting a Type A meeting, to discuss the letter with the agency and seek additional guidance concerning information, data and specific deliverables that the agency would require for a resubmitted NDA to be deemed complete.

Dr. Dennis J. Carlo, President and CEO of Adamis, stated, “We are obviously very disappointed with this development and are evaluating the letter and what the FDA has requested. We intend to work closely with the FDA to try to clearly map the path forward.”

Tadalafil is a drug used for treating erectile dysfunction (ED), pulmonary hypertension and benign prostatic hyperplasia (BPH). Tadalafil is in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors which includes, among others, sildenafil and vardenafil. Tadalafil is the drug in Lilly’s Cialis®, sildenafil is the drug in Viagra® (Pfizer) and vardenafil is the drug in Levitra® (GlaxoSmithKline). All three drugs of these oral tablets are FDA approved and clinically indicated for the treatment of ED.

How does Laxogenin Work?

56786-63-1, also known as Laxogenin, is a plant compound and the best member of Brassinosteroids. Brassinosteroids is a class of polyhydroxysteroids that are seen as sixth class potent hormones, examples are Mustard, Castasterone etc. Brassinosteroids generally increases protein. Structurally, Laxogenin looks like the plant extract ecdysterone and functions as anabolic steroids but Laxogenin is natural and commonly considered to be free of liver-toxic side effects.

Although the process of effect has not been clarified, it however directly increases protein synthesis and reduces protein breakdown. Laxogenin is also believed to enhance muscle recovery and growth by inhibiting the stress hormone cortisol. When consumed in excess, cortisol levels can make it almost impossible to gain muscle or energy. Laxogenin does not perform the function of a prohormone by interfering with the body’s internal secretion of the endocrine glands. Laxogenin neither increases nor decreases endogenous levels of testosterone.

Laxogenin is a naturally-occurring, plant-derived substance, not a synthetic steroid concocted in some pharmaceutical laboratory. On top of that, there has been a substantial lack of research surrounding the actual mechanism behind Laxogenin's mechanism of action.

In other words, scientists still don’t know exactly how Laxogenin does what it does. But, according to the initial studies conducted in Russia, it is significantly increase muscle protein synthesis. Laxogenin has also been found to substantially reduce protein breakdown.

Additionally, some other info about the effects/actions of Laxogenin can be gleaned from the patent application for the ingredient. Specifically, the patent application states that Laxogenin can exhibit adaptogenic traits, helping your body "normalize" its stress response.

Platinum Lab has formulated a natural occurring sapogenin that assists with putting your body through an anabolic state through a non-hormonal pathway by assisting to enhance protein synthesis. This process aids with rapid muscle gains, muscle growth and strength. Not only does this supplement assist with muscle growth, but it also helps with increasing the rate of muscle recovery and balance cortisol response. Cortisol plays a large role in muscle and training recovery and assists in reducing the risk of muscle fatigue.
Since 5a-Hydroxy 56786-63-1 will not affect the hormone levels, restricting 5a-Hydroxy Laxogenin use is no longer needed. Often people use 5a-Hydroxy Laxogenin supplements for up to 4 months, regardless of what the goal is, whether it is to increase performance, build muscles, or reduce body fat.
Common Dosing of 5a-Hydroxy Laxogenin

The typical dose for 5a-Hydroxy Laxogenin is 50 to 100 milligrams per day. This can be cycled up to 12 weeks. It is suggested to have a 4-week break following each cycle to allow the receptors to be up-regulated for greater efficiency.
Use In Supplements

The advantages of 5a-Hydroxy Laxogenin are not as robust compared to anabolic steroids; however, they come with a number of benefits. 5a-Hydroxy Laxogenin is not detected on drugs screen; therefore, athletes who are tested need not be concerned about being caught for using this compound. Moreover, 5a-Hydroxy Laxogenin has no impact on the hypothalamus-pituitary-testicular-axis or estrogen levels; thus, there is no need to conduct a post cycle therapy or utilize an aromatase inhibitor. Anabolic steroids suppress luteinizing hormone and necessitate a robust post cycle therapy for effective recovery outcomes. 5a-Hydroxy Laxogenin can prevent fat gain and increase protein synthesis. It does not strain the liver.

Laxogenin 100a?? body building supplement is the product every athlete or health conscious person has been waiting for! Anyone who wants to build muscle and/or enhance athletic performance and currently is using legal prohormones, growth hormone releasers, and/or creatine supplements needs to pay attention. Laxogenin is the perfect synergistic product to use alongside any growth-related supplement. If you are ready to literally take supplementation to never seen before levels, Laxogenin is it. What is even more interesting is that compared to other testosterone or prohormone products on the market, this is safe for both men and women to take.56786-63-1
5a-Hydroxy Laxogenin is an ingredient Hi-Tech perfected via our synthesis process better than anyone in the industry, given our 23-year history with this ingredient. Hi-Tech's founder used every 5a-Hydroxy Laxogenin going back to the original Mesobolin, put out by Amino Discounters in the early 1990's. For men, Hi-Tech recommends using this product with IGF-1 products like our Pro IGF-1 to assist in lean mass gains. For females Laxogenin 100a?? can be taken by itself and not cause androgenic side effects. Laxogenin 100a?? contains 100mg which isA 2-4 times stronger than its competitors at the same price range. It is also manufactured with Hi-Tech's proprietary Cyclosomea?? technology (described below). A Laxogenin 100a?? is perfect for: