San Francisco’s e-cigarette ban isn’t just bad policy

Anyone over 21, and with an ID to prove it, can purchase cigarettes, booze and even marijuana in retail establishments across San Francisco. But as soon as next month, one age-restricted product won’t be available for purchase, not even online. That’s because San Francisco officials, in a misguided attempt to curb teen vaping, are moving to ban sales of all electronic tobacco products to anyone within the city until the federal government adopts regulations on them.
The San Francisco Board of Supervisors gave a tentative thumbs-up to the ban last week, and the supervisors are expected to reaffirm their support in a final vote Tuesday. We hope the supervisors will see the light before then. Not only is it bad public policy to outlaw a legal product that’s widely available just outside the city’s borders, but it’s bad public health policy to come down harder on the lesser of two tobacco evils.
Electronic Cigarettes are new enough that we don’t fully understand the health effects from vaping, which involves inhaling the fumes produced by heated liquid nicotine. Nicotine in any form comes with health risks. But it’s well established that smoke from conventional combustible cigarettes can kill both smokers and bystanders, and that some longtime smokers have been able to quit that deadly habit by switching to vaping.
Granted, teen vaping is a serious concern. While smoking rates have dropped significantly among U.S. middle school and high school students — they’re down to just about 8% — electronic cigarettes are gaining popularity rapidly. In less than a decade, e-cigarette use among U.S. teens has soared from less than 2% to more than 20%. In just one year, from 2017 to 2018, teen use increased by 36%. The Centers for Disease Control and Prevention reports that, as of 2018, about one-fifth of all U.S. high school students reported using an electronic cigarette in the last 30 days. By comparison, San Francisco’s Youth Risk Behavior Study determined that as of 2017, just 7% of the city’s high schoolers had reported vaping in the last 30 days.
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AAP policy calls for reforms to combat rise in youth e-cigarette use

Electronic Cigarettes Wholesale have exploded in popularity among teens over the last decade, making them the most common tobacco product used by youths. According to 2018 data, one in five high school students and one in 20 middle school students use e-cigarettes, a 75% increase from 2017.

As a trusted source of health information, pediatricians can educate patients and parents about the harms of these products to prevent youth initiation and guide treatment options for tobacco users. Implementation of proven population-based strategies, in coordination with Food and Drug Administration (FDA) regulation of tobacco products, is key to reducing all forms of tobacco product use, including e-cigarettes, among U.S. youths.

The updated AAP policy statement E-Cigarettes and Similar Devices summarizes the latest evidence on the health harms of e-cigarettes and supports both clinical interventions by pediatricians and policy strategies to protect youths from the epidemic of e-cigarette use.
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Study finds electronic cigarettes damage brain stem cells

Aresearch team at the University of California, Riverside, has found that Electronic Cigarettes Wholesale, often targeted to youth and pregnant women, produce a stress response in neural stem cells, which are critical cells in the brain.
Present throughout life, stem cells become specialized cells with more specific functions, such as brain cells, blood cells, or bone. Far more sensitive to stress than the specialized cells they become, stem cells provide a model to study exposure to toxicants, such as cigarette smoke.

Electronic cigarettes, or ECs, are nicotine-delivery devices that aerosolize nicotine and flavor chemicals through heating. Researchers do not yet understand how the chemicals in ECs might affect neural stem cells, particularly their mitochondria — organelles that serve as the cell’s powerhouses and are critical in regulating cell health.

Using cultured mouse neural stem cells, the UC Riverside researchers identified the mechanism underlying EC-induced stem cell toxicity as “stress-induced mitochondrial hyperfusion,” or SIMH. SIMH is a protective, survival response,” said Prue Talbot, a professor in the Department of Molecular, Cell and Systems Biology who led the research. “Our data show that exposure of stem cells to e-liquids, aerosols, or nicotine produces a response that leads to SIMH.”

The study, performed on Vuse, a leading EC brand, appears in iScience, an open-access journal from Cell Press.

“Although originally introduced as safer, ECs, such as Vuse and JUUL, are not harmless,” said Atena Zahedi, the first author of the research paper who received her doctoral degree in bioengineering this year. “Even short-term exposure can stress cells in a manner that may lead, with chronic use, to cell death or disease. Our observations are likely to pertain to any product containing nicotine.”The high levels of nicotine in ECs lead to a nicotine flooding of special receptors in the neural stem cell membrane,” Zahedi said. “Nicotine binds to these receptors, causing them to open up. Calcium and other ions begin to enter the cell. Eventually, a calcium overload follows.”

Zahedi explained that too much calcium in the mitochondria is harmful. The mitochondria then swell, changing their morphology and function. They can even rupture and leak molecules that lead to cell death.

“If the nicotine stress persists, SIMH collapses, the neural stem cells get damaged and could eventually die,” Zahedi said. “If that happens, no more specialized cells — astrocytes and neurons, for example — can be produced from stem cells.”

Zahedi added that damaged stem cell mitochondria could accelerate aging and lead to neurodegenerative diseases. Neural stem cells can get exposed to nicotine through the olfactory route, she explained. Users inhale the fumes, which can travel through the olfactory tracks to reach the brain.
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VAPEFLY JESTER REBUILDABLE DRIPPING POD VAPE KIT 1000MAH & 2ML

Vapefly Jester Kit is the first rebuildable dripping pod system kit. Powered by 1000mAh built-in battery powerful and offering long endurance. There are three output voltage, 3.3V/3.8V/4.8V, for your selection. The 2ml refillable pod adopts top filling with easy operation, and child lock and no leakingdesign makes it more outstanding! There are Two types of cartridges for your selection: one is rebuildable dripping cartridge with single coil build deck to meet your DIY vaping needs, and the other is regular refillable cartridge with unique 0.5ohm mesh coil and adjustable bottom airflow to bring you purer flavor. In addition, the battery status can be simply told from the three LED indicator lights. Enjoy the sparkle of vaping life brought by Jester!

Feature:
First rebuildable dripping pod system
Optional rebuildable dripping pod and refillable mesh pod
Unique mesh pod and adjustable airflow for purer flavor
Pod release button for easy movement with child-lock design
3 output modes meet different needs
2ml e-liquid capacity, easy to refillable
Top add can effectively prevent oil leakage

Technical Data:
Size: 33 x 18.2 x 91mm
Pod capacity: 2.0ml
Battery: 1000mAh built-in Battery
3 Output Modes: 3.3/3.8/4.8V
Coil resistance: 0.5ohm Mesh coil, 1.0ohm coil
Rebuildable Dripping Pod Recommended: 0.8-1.5ohm

Package Includes:
Jester Pod DIY Edition:
1 x Vapefly Jester Battery
1 x Vapefly Jester Cartridge
1 x Vapefly Jester Dripping Cartridge
1 x 0.5ohm Mesh Coil
2 x 1.0ohm Coils
2 x Firebolt cotton
1 x USB Cable
4 x Screws
1 x Screwdriver
1 x User Manual
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VAPORESSO GEN 220W & SKRR-S STARTER KIT

The vaporesso gen mod is a high-powered vaping system equipped with a comprehensive temperature control suite, embedded with the new AXON Chipset and is paired with the flawless Vaporesso SKRR-S Sub-Ohm Tank to create a cloud-chucking vaping monster that will satisfy any level of vaper. Within the zinc alloy chassis is a AXON Chipset that results in a broad range of applicable resistances for the GEN Starter Kit and allows the GEN to access other modes like Pulse Mode. This innovative Pulse Mode fires every 0.2,s to maintain the temperature control settings previously input, creating a delicate controlled vaping experience. In addition, the AXON Chipset releases the full potential of the GEN Starter Kit, unlocking the comprehensive temperature control suite to adjust the temperature of the hit to maintain a smooth and enjoyable vape that can be further adjusted to find the absolute perfect vape, Furthermore, the Vaporesso GEN 220W TC Box Mod is paired with the Vaporesso SKRR-S Sub-Ohm Tank, a versatile tank holding up to 8mL of today's most popular eJuice, utilizing coils from either the Vaporesso QF Coil Series or the Vaporesso GT Coil Series within the SKRR-S Sub-Ohm Tank to create luscious clouds of dense flavor.

Vaporesso GEN 220W TC Box Mod Features:

AXON Chipset
Dimensions - 146mm by 54mm by 30mm
Dual High-Amp 18650 Batteries - Not Included
Wattage Output Range: 5-220W
Resistance Range: 0.03-5.0ohms
Zinc-Alloy Chassis Construction
Soft Touch Rubberized Coating
Power Mode
Pulse Mode
Intuitive Firing Button
OLED Display Screen
Two Adjustment Buttons
Short Circuit Protection
Burn Protection
No Load Protection
Overtime Protection
Low Resistance Protection
Low Power Protection
Overcharge Protection
ESD Circuit Protection
Pass Through Protection
MicroUSB Port
Available in Silver, Black Blue, Black Red, Black
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Best Cheap Vape Mods Under $50

Getting started with vaping doesn’t have to be expensive. We conducted several polls asking cheap vape deals to vote for their favorite devices, and this post will use the results to put together a definitive list of the best cheap vape mods, ecig mods, and box mods under $50. Not only are these devices widely-loved by vapers, you can pick each one up for less than the average price of 10 packs of cigarettes – and much fewer if you live in a state with high cigarette prices like New York.

So what are the best vape mods for under $50? For anybody interested in starting to vape but not wanting to spend too much getting set up, these affordable e-cigarettes are the perfect solution.

This isn’t an exhaustive list, though, so even if none of our readers’ or our staff's picks for the best ecig mods under $50 appeals to you, there are many other options on the market too – we’ll be adding a buying guide soon to help you find a device that’s both high quality and affordable.So here’s the top 10 cheap vape mods for under $50! This list was created based on the results of our polls of the best starter kits and VV/VW (variable voltage and variable wattage) vape mods, and based on prices at the time of most recent update (April 2019).
The Smok Priv V8 kicks off this list of the best beginner e-cigarettes on the market thanks to the super-affordable price, it’s compact and stylish design and the fact it still has a substantial power output. It runs on a single 18650 battery – which you have to pick up separately – but it’s still really beginner-friendly and the performance is up there with that from much more complicated mods.

The Priv V8 is a direct voltage output device, which means that the power you get from it depends on the charge level of the battery. On a full charge and with a 0.15 ohm coil, you’ll be vaping at an impressive 60 W. It has a side-mounted fire bar, so you just squeeze to vape, and LED lights serve as indicators to let you know the battery level and help you monitor charging. The device comes with the TFV8 Baby Beast tank, which has a top-filling design, a 3 ml juice capacity and two 0.25 ohm dual coil atomizer heads.

The price is one of the biggest selling-points of the device, available for just $31.95. If you want a straightforward but high-performance vaping experience without breaking the bank, this is an outstanding option.
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Vaporesso GEN 220W Box Mod

The vaporesso gen mod 220W Box MOD is easily accessible to make high power devices than before. The GEN MOD has 220W power, of course there ia smooth and durable great texture. GEN can give extra throughout every inhale to provide an extraordinary punch. The GEN MOD is similar to the Vaporesso GEN MOD kit, all with the new AXON chip. It is easier to operete than before. In addition, the Vaporesso GEN MOD has four modes for you opetion. Finding the mode which you want and enjoying vaping.
Features:
All-new Axon chipset
Innovative PULSE mode and SMART TC mode
Lightweight with powerful 220W
2.5A fast charging system
Improved secondary air flow distribution for richer flavor

Brand: Vaporesso
Unit: 1pc/pack
Size: 93.5*30*54mm
Output Wattage: 5-220W
Battery: 2x18650 Batteries(Not Included)
Display: 0.91inch OLED Screen
Mode: Pulse Mode/Power ECO/Smart TC/DIY
Charge Current: 2.5A
Resistance Range: 0.03-5ohm
Thread: 510
Package: Gifts Box
Shipping method:Please check here for details.
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Although Sildenafil (Viagra), vardenafil (Levitra), and Tadalafil powder (Cialis) all work by inhibiting PDE5, Tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to Sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.

A high-pressure liquid chromatography-diode array detection and multi-mode ionization tandem mass spectrometry (HPLC-DAD-MMI-MS/MS) method was used to identify tadalafil and rimonabant in electronic cigarette (e-cigarette) cartridges. Amino-tadalafil is a drug similar of the commercially approved ™ (i.e. tadalafil). Rimonabant is a drug that was, at one time, approved for weight loss in Europe (although approval has been retracted), but not in the United States. In addition, poor quality control over the e-cigarette products analyzed here is shown by the presence of nicotine in products labeled as containing no nicotine or by the presence of significant amounts of rimonabant oxidative degradant in e-cigarette products containing rimonabant. Identification was accomplished by comparing the retention time of relevant peaks in the sample with those of standard compounds, in addition to comparison of the UV spectra, mass spectra and/or product ion mass spectra.

Dutch Olympian Kira Toussaint has tested positive for the banned substance Tulobuterol(56776-01-3), according to a post on the athlete’s Instagram page.

According to her post, Toussaint was notified about her positive test from FINA on December 7, just before the start of the 2018 FINA Short Course World Championships. The positive test came from a sample on November 2, during the FINA World Cup stop on Beijing.

The Dutch backstroker had a strong showing during the FINA World Cup, ending the tour with the 8th highest total for prize money among all female swimmers competing, and would have been a strong podium contender in multiple events at the Short Course World Championships.

In Toussaint’s statement, she claims innocence and says she did not knowingly ingest the substance. The backstroker claims she takes a similar medication to treat her asthma, and that she is currently investigating how the illegal substance ended up in her system. At the time of this posting, the case is not currently listed on FINA’s Anti-Doping website.

Tulobuterol HCL (56776-01-3) is a long-acting beta2-adrenergic receptor agonist. Tulobuterol has almost no effects on blood pressure and heart rate and is highly selective for the tracheal muscle. It is indicated to improve symptoms such as respiratory distress caused by airway obstruction of bronchial asthma, bronchitis, chronic obstructive pulmonary disease (COPD) and emphysema. Serious side effects detected were: tremor, palpitations and serum potassium level decrease.

Product Name Tulobuterol HCL
Chemical Name 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol hydrochloride
Brand Name Tulobuterol Hydrochloride
Drug Class beta2-adrenergic receptor agonist
CAS Number 56776-01-3
InChIKey RSLNRVYIRDVHLY-UHFFFAOYSA-N
Molecular Formula C12H19Cl2NO
Molecular Weight 264.19
Monoisotopic Mass 263.0844 g/mol
Melting Point 159-164°C
Boiling Point 338.2 °C at 760 mmHg
Biological Half-Life N/A
Color White powder
Solubility Soluble in DMSO
Storage Temperature 0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Application Tulobuterol HCL is a long-acting beta2-adrenergic receptor agonist.