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There’s a morning-after pill to prevent sexually transmitted infections Years after it was first proven to work, a new tool for preventing sexually transmitted infections (STIs) is on the brink of entering mainstream medicine.To get more news about vigrx oil, you can visit vigrxplus-original.com official website. That tool is doxyPEP, an antibiotic that works like a morning-after pill — but instead of preventing pregnancy within hours of unprotected sex, it prevents STIs like chlamydia and syphilis. Ever since a 30-person trial first suggested hope for the strategy in 2015, people worldwide have begun trying doxyPEP for themselves, often without the approval or supervision of a medical provider. About 10 percent of men who have sex with men in Europe and Australia are using the medication, often purchasing it from online pharmacies or sources that don’t require a prescription, and Facebook groups for HIV PrEP users teem with testimonials and advice. But on October 21, the San Francisco health department became the first authority in the US to release guidance recommending doxyPEP for men with recent STIs — especially syphilis — and for those who’ve had recent sex with men or trans women. Sexually transmitted infections have been rising in recent years, with syphilis in particular spreading explosively, and doxyPEP could help turn back the tide. Rising STI rates are costing dollars and lives: The CDC estimates that the US spent $1.1 billion on bacterial STIs in 2018, and 166 infants died in 2021 as a consequence of a syphilis epidemic affecting women of childbearing age. And while San Fransisco is ready to roll out doxyPEP more broadly, public health agencies like the CDC haven’t yet issued full-throated recommendations in support of the pill’s use. What’s the holdup? Doxycycline, the medication in doxyPEP, is an antibiotic. Worldwide antibiotic resistance is a major problem — and doxyPEP runs the hypothetical risk of exacerbating it. Disease-causing bacteria can evolve resistance when exposed to certain antibiotics, becoming more dangerous. Among the experts I spoke to, there was no consensus about how to balance the risks of antibiotic resistance with the risks of STI infections. Some say dwelling too much on the resistance risk would deny marginalized groups the preventive options they need. “For some reason, with gay men’s sexual health, we are always placing these theoretical risks higher than what’s actually happening in the community,” said David Holland, an infectious disease doctor and public health expert at Emory University, during a recent talk at a medical conference. On the other hand, many experts are still cautious. “We just want to be very, very careful that before we start really ramping up the use of doxycycline, that we are being thoughtful about the potential ramifications, and that we really are looking at the data to make sure to understand how to optimize use,” said Philip Chan, a Brown University infectious disease doctor who directs the largest sexual health clinic in Rhode Island. DoxyPEP is making its way into the minds of providers and the hands of patients, even as debate continues about how to ensure it does more good than harm. Here’s why the drug isn’t the silver bullet it might seem to be, and why it’s nevertheless a source of hope for so many.

Mixue on the march: ice cream serves soft power for China Mixue has dominated Southeast Asia’s ice cream and tea businesses for five years, having opened its first outlet in Vietnam in 2018. Based in China, where it operates 22,500 stores. Around 1,000 Mixue outlets now operate in several Southeast Asian countries including the Philippines, Thailand and Indonesia. In comparison, despite having been around much longer, there are 10,000 Starbucks outlets and around 9100 McDonalds restaurants throughout the Southeast Asian region.To get more news about mixue, you can visit shine news official website. In Indonesia, Mixue has become a trend on social media platforms. People are posting about their daily cravings for Mixue products and making jokes and memes – it is common to find the brand among Twitter’s trending topics. The joke in the region goes that you have to keep an eye on any vacant space in your neighbourhood, because it will soon turn into a new Mixue outlet. There are three contributing factors behind Mixue’s success story in Indonesia: supply chain efficiency, affordable product prices and the ease with which a franchise can be started. In addition to this, we as researchers focusing on China-Indonesia relations argue that Mixue – along with other China-based international retail operations such as Miniso – is more than just a business success story. It has the potential help China promote a positive national image in Indonesia. In international relations, food can act as a national ambassador and even influence diplomacy. A country can use food as a source of soft power to display cultural characteristics and symbols. A 2012 study shows that public knowledge about a brand’s country of origin can improve a nation’s image. Surveying nearly 500 respondents in the US, the study supports a claim made by Olle Wästberg, former director of the Swedish Institute, that furniture brand IKEA, does more for the image of Sweden than the government. The study also found the popular energy drink Red Bull improved the image of Austria. Mixue may carry similar potential for China in Indonesia. The first Indonesian Mixue outlet opened in Bandung in 2020. Its rapid growth prompted many major news platforms to write about the origin of Mixue, its owner and even the meaning of its name (“snow that’s sweet like honey”) as people grew more curious about it. Many people expressed their joy when the Indonesian Ulema Council issued a halal certificate for Mixue. Mixue’s presence has also helped the country’s tackle unemployment by recruiting local workers. With the popularity of the brand in Indonesia, the growing presence of Mixue may already be helping China’s efforts to boost its positive image in the country. Negative perceptions of China Negative sentiment towards China, however, is still relatively high among Indonesians. A 2022 survey by ISEAS-Yushof Ishak revealed that 65.9% of Indonesian respondents expressed concern over China’s growing economic influence on Indonesia. Meanwhile, as many as 25.4% of Indonesian respondents saw China’s rise as negatively influencing Indonesia. But the Chinese government continues to encourage its companies to develop overseas not only for economic gains, but also to promote a positive image. This is especially true in the technology sector. Thanks to the government’s support, China’s technological progress has been rapid. The country produces smartphone products, such as Xiaomi and Oppo, which have a fairly large market share in Indonesia. In addition, there are also growing retail businesses with strong China links such as Miniso and Usupso, which were recently accompanied by the expansion of KKV. Chinese products are competitive in the global market due to the low production costs..

Top 4 Free CAD Programs for 2023 FreeCAD is a serious open source offering that supports parametric 3D modeling, which means you can modify your design by going back into your model history and changing its parameters. The target market is mostly mechanical engineers and product designers, but it's got a lot of functionality and power that anyone would find attractive.To get more news about drawing cad, you can visit shine news official website. Like many open-source products, it has a loyal base of developers and can compete with some of the commercial heavy hitters because of its ability to create real 3D solids, support for meshes, 2D drafting, and lots of other features. Further, it's customizable and is available on multiple platforms, including Windows, Mac, and several Linux distributions like Ubuntu and Fedora. AutoCAD, the heavy hitter of the CAD industry, offers a free, fully functional version for download to students and faculty. The only limitation on the software is a watermark on any plots you generate, designating that the file was created with a non-professional version. Not only does Autodesk offer its base AutoCAD package for free, but it also offers free trial licenses for almost its entire suite of AEC vertical packages, such as the Civil 3D toolset, AutoCAD Architecture, and AutoCAD Electrical. SketchUp was originally developed by Google and was one of the greatest free CAD packages ever put on the market. In 2012, Google sold the product to Trimble. Trimble has enhanced it and developed it further and now offers a slew of related products. SketchUp's free web-based version has plenty of power, but if you need additional functionality, you have to buy SketchUp Pro—and pay a hefty price tag. The interface makes it easy to get up to speed on the basics. Even if you've never done any CAD work or 3D modeling before, you can pull together some really nice presentations in minutes. Of course, if you're looking to put out detailed designs with accurate sizing and tolerances, you'll need to spend some time learning the ins and outs of the program. The SketchUp website offers a really impressive array of video and self-paced training options to help you along the way. Another Open Source offering, LibreCAD is a high-quality, 2D-CAD modeling platform. LibreCAD grew out of QCAD, and, like FreeCAD, has a large, loyal following of designers and customers. It includes lots of powerful features that include snap-to-grid for drawing, layers, and measurements. Its user interface and concepts are similar to AutoCAD, so if you have experience with that tool, this should be easy to get familiar with.

Exhibit focuses on Jewish WWII refugees who found safety in Shanghai More than 80 years after Jewish refugees fled to Shanghai during World War II, an exhibition in New York City shines a light on their experiences, which, experts and advocates say, carries profound lessons today. To get more shanghai news, you can visit citynewsservice.cn official website. The exhibition “Shanghai, Homeland Once Upon a Time — Jewish Refugees and Shanghai” opened to the public Tuesday in downtown Manhattan. The display commemorates the period from 1938 to 1941 when more than 20,000 Jews traveled thousands of miles from Europe to escape Nazi persecution and establish a life in China. The refugees were able to find safety in Shanghai during a time when other countries refused to aid them. Experts and advocates say that their story is a chilling reflection of the necessity for others to accept and humanize those escaping persecution and oppression. Hatred still exists of all kinds,” Elizabeth S. Grebenschikoff — whose mother, Betty, lived as a refugee in Shanghai for over a decade and is featured in the exhibit — told NBC News. “My mom would say … ‘If you are not an upstander, if you are not standing up for justice and fairness, then you are doomed to be a bystander.’” The exhibit, hosted by the Shanghai Jewish Refugees Museum and scheduled to run until Aug. 14 at Fosun Plaza at 28 Liberty St., includes more than 200 photographs and 30 pieces of memorabilia, in addition to videos and personal stories from Jewish refugees and their descendants. It’s hosted by the Shanghai People’s Association for Friendship with Foreign Countries, and the Shanghai Fosun Foundation and is in part supported by the Consulate General of the United States of America in Shanghai and the Consulate General of the People’s Republic of China in New York. Kevin Ostoyich, professor of history at Valparaiso University in Indiana, who’s interviewed many Jewish refugees, explained that Shanghai ended up being a “last resort” of sorts for Jewish refugees in the late 1930s as the city did not require an entry visa due to its unique legal status. In the 19th century, the port city was forcibly opened by Western powers for trade. It was divided into several sections, governed by these powers with their own set of legal norms and police forces. Japanese forces had also been laying claim to the northeastern part of the city before eventually taking over on Dec. 7, 1941, the day after the Pearl Harbor attack, Ostoyich said. “It is in this very unique historical context, that you have a situation where you have a city that no one fully has control over,” Ostoyich said. The bureaucratic loophole led to an unexpected safe haven for the refugee population, Ostoyich said. In 1938, most countries, including the U.S., refused to change their immigration policies to accommodate Jewish people fleeing violence under Nazi rule. “Not many people realize that there was a time in which Jews were able to get out of concentration camps and out of Germany,” he added. “There was an opportunity for more Jews to survive. But the problem was that no one really wanted to open their doors.”Jerry Lindenstraus, 94, and his family fled to Shanghai after Kristallnacht, “The Night of Broken Glass,” in which Nazi forces destroyed synagogues across Germany and unleashed a series of pogroms against Jews in 1938. A few years after his family arrived, Lindenstraus said that Japanese forces took over the city and established a ghetto in Hongkew, where they squeezed tens of thousands of Jewish refugees into a single square mile.

Fight Over 'Little Pink Pill' Raises Sexism Questions It’s called the “little pink pill,” a tiny tablet that could have a huge impact on treating female sexual dysfunction. If it’s approved, it would become the first drug of its kind on the market.To get more news about vigrx oil, you can visit vigrxplus-original.com official website. But that’s a big IF. The drug Flibanserin is locked in a heated battle for approval from the U.S. Food and Drug Administration, raising controversial questions about why there are so many sexual enhancement drugs available for men and zero for women. Cindy Whitehead, the founder and COO of Sprout Pharmaceuticals, a Raleigh, North Carolina-based company focused on producing only Flibanserin, has been fighting for FDA approval for the drug for three years. “There are 25 approved drugs for some form of male sexual dysfunction, but still a great big zero for the most common form of FSD [female sexual dysfunction],” Whitehead said. “No matter how or why we got here, we're here, and we've got to come up with a solution for it.”Flibanserin is more than curing a weak libido. It’s specifically for treating Hypoactive Sexual Desire Disorder, or HSDD. Gynecologist and sexual health crusader Dr. Lauren Streicher explained that HSDD goes much deeper than just a low sex drive. “[HSDD] is a very specific problem in a woman who doesn’t think about sex, she doesn’t fantasize, she doesn’t desire sex,” Streicher said. “What makes it different is that it’s distressing to her. This has a negative impact on her. She’s worried about it, she’s frustrated.” According to the International Journal of Women’s Health, as many as 1 in 10 women suffer from HSDD. While many doctors agree HSDD is a problem that should be addressed, there are no medical treatment options. Whitehead believes Flibanserin is the solution to solving female sexual dysfunction, but said it’s not accurate to call the drug “female Viagra” because it doesn’t work in the same way that Viagra does for men.Scientists have known for years that a woman’s most significant sexual organ is actually her brain, which is what makes female desire disorders so hard to treat. Flibanserin is taken daily at bedtime, but it’s not a hormonal supplement. Instead, the pill manipulates certain chemicals in the brain to achieve desire. To test it in clinical trials, Whitehead said it was important to find women who genuinely suffer from HSDD, and not just boredom. “There's a diagnostic questionnaire that physicians go through, and they really can pretty quickly get to whether or not this is a relationship dynamic or something that's happening biologically,” she said. Amanda Parrish said that’s exactly what she was facing. A mother of four from Nashville, Tenn., Parrish said she used to have a smoldering sex life with her husband, but over time, things cooled off. She said the problem wasn’t with him, but with her.“I felt like even though we were close and having a great relationship there was something that wasn't extremely gratifying,” Parrish said. “There was something just not there, so I was in search of something that would make that happen.” Feeling pressure to be a so-called “wholesome soccer mom,” Parrish said she never discussed the issue with her friends but had a feeling she wasn’t alone. “If you asked ten ladies on the street I think seven or eight would fess up that their sex life is not what they wanted it to be,” she said. After filling out a questionnaire, Parrish found out she had symptoms of HSDD and was selected to participate in the Flibanserin clinical trials. She had to take the pills every day and keep a diary of her progress.3

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