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Belviq (Lorcaserin hcl) is a serotonin 2C receptor agonist. It has been shown to decrease food consumption and promote satiety by selectively activating serotonin 2C receptors in the brain.
Belviq is specifically indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in clinically obese adults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 or greater) with at least one weight-related comorbid condition.
Belviq is supplied as a tablet designed for oral administration. The recommended dose is one 10mg tablet twice daily. Use of Belviq should be discontinued if 5% weight loss is not achieved by week 12 of treatment.
Clinical Results
FDA Approval
The FDA approval of Belviq was
based on the results of three randomized, double-blind,
placebo-controlled trials with durations ranging from 52 to 104 weeks.
Study 1 and Study 2 were conducted in adults (n=3182, n=4008;
respectively) without type II diabetes, and Study 3 was conducted in
adults (n=604) with type II diabetes. All subjects were administered
Belviq 10mg twice daily. The primary endpoint for each study was weight
loss at one year as assessed by percent of subjects achieving greater
than or equal to 5% weight loss, percent of subjects achieving greater
than or equal to 10% weight loss, and mean weight change. Belviq was
administered in conjuction with one-on-one instruction for
reduced-calorie diet and exercise counseling at the first dose and at
every four weeks during the trials. Study 1 was a two-year trial, and
Study 2 and Study 3 were one-year trials. Statistical significance was
achieved in each group of Belviq-treated subjects compared to placebo
upon evaluation of 5% weight loss or greater.
Belviq (lorcaserin hydrochloride) is a serotonin 2C receptor agonist.
While the complete mechanism of action is not entirely understood, it is
believed to decrease food consumption and promote satiety by
selectively activating 5-HT2C receptors on anorexigenic
pro-opiomelanocortin neurons located in the hypothalamus.
LGD-4033 is a selective androgen receptor modulator (SARMS), and a novel non-steroidal SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity. It's in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an route of administration.Best Sarms Powder
Best Bodybuilding Product Sarms Powder Lgd4033
Increasing lean mass gains
Enhancement for strength
Bodybuilding exercise
Joint healing abilities
Hormone Anabolic raw material
It shows anabolic activity in the bones and muscles instead of harmfully
affecting the prostate and sebaceous glands which usually happens when
using steroids. LGD-4033 just concluded a study called Phase I Multiple
Ascending Dose which included fit volunteers. This was an unplanned,
double bind analysis stage that included a placebo.
Enobosarm (Ostarine, MK-2866, GTx-024) - affects both muscle and bone, intended mainly for osteoporosis but also general treatment for andropause and reversing muscle sarcopenia in the elderly and for cachexia in cancer patients
Nonsteroidal selective androgen receptor modulator (SARM) used in the treatment of osteoporosis and muscle wasting in animal models. A potential compound for the treatment of hypoactive sexual desire disorder.
For Recomping---
Ostarine shines in recomping due to its nutrient
portioning results. Calorie is used to build muscle which helps in
weight loss and enhancing muscle mass and strength.
Quick Details:
Product Name: Nootropics powder
Chemical name:N-[(5-Hydroxy-3-pyridinyl)carbonyl">-L-glutamic acid
N-(5-hydroxynicotinoyl)-L-glutamic acid
N-(5-Hydroxymethyl-pyridin-2-yl)-2,2-dimethyl-propionamide
CAS 112193-35-8
Formula:C11H12N2O6
Molecular weight: 268.23
Appearance: White powder
Assay: 99% min by HPLC
Nooglutyl is a nootropic agent being studied at the Research
Institute of Pharmacology, Russian Academy of Medical Sciences as a
potential treatment for amnesia.
In animal models, it has a variety of central nervous system effects.
Nooglutyl is a nootropic agent being studied at the Research
Institute of Pharmacology, Russian Academy of Medical Sciences as a
potential treatment for amnesia.In animal models, it has a variety of
central nervous system effects.
Experiments on rats demonstrate that
nooglutyl exhibits pronounced vestibular-protective properties and by
its antimotion activity does not rank below classic vestibular
protectors, such as scopolamine and diprazine. Electrophysiological
experiments on cats show that nooglutyl alters spontaneous activity in
80% of cortical neurons (somatosensory zone I and area 5 of the parietal
association cortex) and considerably weakens effects caused by motion
sickness: activation of single unit activity of somatosensory zone I and
inhibition of neuron responses to somatic stimulation. This property of
the preparation is believed to form the basis of its antimotion effect.
Product Description
Name:Choline Bitartrate
Other name: 2-(Hydroxyethyl)trimethylammonium bitartrate
CAS NO.: 87-67-2
EINECS NO.: 201-763-4
MF: C9H19NO7
MW: 253.25
Boiling point: 399.3°C at 760 mmHg
Flash point: 209.4°C
Appearance: colorless or white crytal powder, easy to moisture, whose quality has reached to the FCCIV and USP standards.
Specification: 99% min
Standard: EP/BP/USP
Description of Choline bitartrate :
Choline bitartrate is a nutritious additive and fat remover. It can enhance fatty metabolism in human beings and eliminate the accumulation of fatty in liver. Being a product of vitamin, it can be applied to medicine, healthcare product and food. L(+) choline bitartrate now has the tendency of replacing the choline chloride crystal and DL- choline bitartrate when being used for children and mother-to-be. The pure one is to be colorless or white crytal powder, easy to moisture, whose quality has reached to the FCCIV and USP standards.nootropics
Choline bitartrate is a form of choline that is readily absorbed by the body. It provides about 7 times as much choline as the more commonly used phosphatidylcholine supplements and up to 10 times as much choline as lecithin. You need 7 to 10 times as much of phosphatidylcholine and lecithin supplement as choline supplements to get the same nutritional benefit.
The main functions of the choline chloride is as following:
1. To prevent the accumulation of fat in livers and kidneys and avoid its pathollgical changes;
2. To enhance the health of animals and to improve it's ability toanti-illness;
3. To increase the growth rate and laying rate of fowls and to increase the survival rate of baby pig;
4. To increase the growth and survival rate of fishes and promote its propagation;
5. To ensure the proper functioning of the nervous system of animals;
Due to its common pyrrolidone structure, aniracetam is a compound in racetams. It is one of the more common Racetamic structures. It is fat soluble and therefore requires the intake of fatty acids. In addition, Aniracetam is cholinergic
Aniracetam powder acts as a positive regulator of some excitatory receptors called AMPA receptors and reduces the rate of receptor desensitization. This usually manifests as controlled and prolonged neurostimulatory effects. Because AMPA receptors are structurally different throughout the brain, different AMPA modulators affect the brain in different ways.
Interestingly, Aniracetam is believed to contribute to "collective and holistic thinking" or to put these puzzles together. It also increases blood flow and activity in the brain area, and this area is the action, the cortical association.
Aniracetam, an AMPA modulator, is currently being studied for
depression and other CNS diseases such as Alzheimer's disease.Aniracetam
Powder is a Nootropic supplement. This supplement is can help increase
and improve a number of cognitive processes.
Aniracetam also
exhibits anxiolytic properties and enhances mood alongside memory and
focus. This supplement has been well-studied
for a number of years and is known to be generally very well-tolerated with minor side effects.
Aniracetam Powder is considered a fairly safe and low toxicity
substance to improve cognition and memory or reduce anxiety symptoms.
Like other racetams, it can have an added benefit of reducing free
radicals and oxidative stress in the brain which can lead to
degenerative
diseases and neurological complications. It should not
be used as a main line of defence or treatment for degenerative diseases
like
Alzheimer's and Dementia but may have merit in reducing some of the symptoms associated.
These days, Tungsten jewelry is everywhere. In 1939 Bechuanaland automatically declared war on Germany with Great Britain There was chiefly resistance when, in early 1941, the call went out again for unarmed "native labourers" to join the South African detachments fighting under the British in Egypt.
The Sultan of Oman declared war on Germany on 10th September 1939. The Iranians disliked the British for their significant research and control of their oil and their sphere of influence on the country, coupled with the fact that the Iranians, were receiving modern military equipment from Germany.Celtic Tungsten rings men
Like all the other British colonies in the West Indies, Guiana gave full support to the Allied war effort by providing personnel for the British Armed Forces, land for an American military base (Atkinson Field opened 20th June 1941) and Bauxite raw material for aluminium production.
In all, approximately 2,000 people in the Andaman's are thought to have either died or been executed as a result of the occupation, and at least 500 were severely tortured by the Japanese. Carved Tungsten Carbide: Carved tungsten carbide rings is a fairly new technology, only being found at a few retailers.
Made from exquisite precious and semi precious metals and gemstones, earrings rule the men's jewelry segment. British police continued in their pre-war manner and did not act for the Nazis but rather protected the Islanders, against the draconian German military laws, where they could.
The involvement of the British Colony of Kenya in the Second World War began with the declaration of war on Nazi Germany by the British Empire in September 1939. On 13th Oct 1943, the government of Italy declared war on its former Axis partner Germany and joined the battle on the side of the Allies.
He refused once again and in August 1941, the British, Indian and Soviet troops invaded Iran (Operation Countenance) and in September 1941, forced Reza Shah Pahlavi to abdicate his throne. From a total of 140,000 Dutch Jews, only 30,000 would survive the German occupation, murder and the war.
Trans-Jordon, however, was a British ally during the War and the Trans Jordanian forces were under British command during the war. Tungsten rings are made from a unique process in which Tungsten and Carbide powder are forged together, creating a nearly indestructible ring.
A few years ago, when Tungsten was relatively unheard of, people always compared tungsten to titanium to show off its fabulous traits and characteristics. Also, tungsten also does not lose its color like white gold does after a short time of wear. Within a few days, Britain and France declared war on Germany and began mobilizing their armies while at the same time preparing shelters for their civilians from the arrogant Nazis.flat tungsten rings for men
The last thing they wanted was yet another bloody, crippling war, but during the 1930s it became more obvious that the rise of the Fascist party in Germany was leading to this eventuality. Consider a fairly basic tungsten carbide ring design - simple round wedding band.
The leftist administration of President Rafael Ángel Calderón Guardia was hostile to Nazism and declared war on Japan the day after the attack on Pearl Harbour, and on Germany and Italy shortly afterwards. During World War II, 4,000 Argentines served with all three British armed services, even though Argentina was officially a neutral country during the war.
Due to the rising price of gold and the general economic climate, many people today would settle for cheaper silver pendants and rings as opposed to gold. However, many Polish troops and servicemen escaped and were welcomed into the forces of the British with experienced Polish pilots serving with distinction in the Battle of Britain.
Many tungsten wedding band companies can manufacture to a 12mm width, some manufacturers design rings even wider, at times to a 16mm width. The light grey color of tungsten carbide wedding ring matches any clothing and gives a gorgeous look to the person who wears it. Besides carbide, tungsten is also inlaid with platinum, palladium, sterling, silver and gold.
To set the record straight, tungsten carbide is the hardest and most scratch resistant or wear resistant metal known to man. Another of the South American nations to join the Allies very late in the war (joined against Germany on 2nd February 1945 and let USA use Baltra Island for a naval base).
The occupation of Latvia by Nazi Germany was completed on 10th July 1941 by Germany's armed forces. A true tungsten carbide ring is skillfully polished using diamond polishing tools and wheels, which creates a permanent luster and polish that is not seen with other metals.
Search Associates welcomes Shanghai school
(SMIC) to its catalog of member schools. SMIC is a K–12 day school
whose campus of approximately 80,000 square meters is surrounded by
green spaces and gardens. The school was established in September of
2001 by the Semiconductor Manufacturing International Company. The
initial goal was to provide a quality education solely for the children
of foreign and domestic employees of the company, but three years later,
the school opened its doors to non-SMIC children, making its
high-quality education available to the wider community. Currently,
approximately 22% of enrolled students are children of SMIC employees.
In his “Welcome” message on the school website, Chancellor and Executive
Director of the SMIC School Board Dr. Jack Chou describes SMIC:
Fully-accredited by the Western Association of Schools and Colleges,
SMIC not only offers Advanced Placement courses for the upper levels of
the secondary school, but it also serves as an AP and SAT testing
center. Currently, 1,275 students are enrolled, with 65% from North
America and the U.K. The teaching staff of 116 includes 74 from North
America, 37 from China, and five from the U.K. The school’s extensive
facilities feature four auditoriums, multiple science labs, art and
music rooms, outdoor basketball and tennis courts, soccer fields, and
running tracks. The kindergarten and elementary campuses include
newly-renovated playground areas for recess.
SMIC provides enrichment opportunities for every child. The Visual
and Performing Arts Department’s (VAPA) curriculum follows American
standards adapted from California and the Common Core. Students in
Grades K–8 take art and music, each once a week, and by Grades 4 and 5,
students may also join in extracurricular orchestra and/or choir. In
Grades 6-12, students can participate in mini-orchestra, drama, choir,
and art club. High school students must take at least one of the VAPA
courses: Art & Creativity (regular and advanced), 3D Art, Digital
Illustration, AP Studio Art, Orchestra, Contemporary Rock, Band, or
Drama. Moreover, students in high school have more than 35 clubs and
activities to join, while elementary and middle school students can
choose from 13 and four, respectively. Finally, as one of the founding
members of the China International Schools Sports Association (CISSA)
and the Shanghai International School Activities Conference (SISAC),
SMIC competes in two of the top sports leagues in all of Asia. SMIC
coaches more than 50 teams in tennis, cross-country, volleyball,
basketball, table tennis, badminton, track & field, swimming, and
soccer. The “Sharks of Pudong” have won many league championships, or
made it to the finals!
Annual school-wide events make SMIC a special
place to be: Sports Day, the Science Fair, performing arts concerts,
the Spring Art Show, and field trips to destinations in Shanghai. On
Vocabulary Day, teachers and students make their own costumes
illustrating a vocabulary word of their choice, and then they have a
parade! On International Day, each class in the elementary school adopts
a country to research in order to create performances and exhibits for
their families. Middle school students present their class projects
based on a variety of historical and cultural topics, and high school
seniors lead workshops and small group discussions on topics such as
social justice, humanitarian aid, and the preservation of cultural and
ethnic diversity. Awards are given on this day to the winners of the
Global Citizenship Day Essay and Poster, and the Grade 12 Global
Citizenship students honor a member of the Shanghai community with
SMIC's Global Citizen Award.
SMIC is interested in hiring single teachers and married teaching couples. They will consider exceptional teachers who are newly certified as well as outstanding, experienced teachers who lack certification. Teaching couples who are not married, couples with a non-teaching spouse, and interns will also be considered. All candidates must hold their academic degree in the subject that they will be teaching. China issues work visas up to the age of 60.
The salary and benefits package includes a settling-in allowance and 70% of a teacher’s rent. SMIC covers one annual airfare for home leave, which extends to spouses and all dependents under 18. Families receive an 80% tuition benefit for up to two children, and teachers pay a percentage of the worldwide health insurance coverage, life insurance, and long-term disability. Daily lunch is free, and SMIC promises extensive professional development opportunities internally and externally. There are local employment opportunities for non-teaching spouses. This package allows for some savings or the opportunity for a family of four to live on one salary.
well informed of their target audience – children, parents and infants all inhabiting the same areas – the team of designers considered the habits and behaviors of all of the groups. the designers divided the parent-child swim club into five main functional areas, all flowing through seamlessly from once space to the next through a fantastic narrative.
a big whale that wraps around a column, jumping out of the water welcomes visitors when entering the building through the reception area. the area features a desk in the shape of a ship and a small arc lace outlined on the bottom is meant to represent a wave pushing the ship and the narrative to the next space. passing through the reception and the shoe changing area, guests are led on to the reading room.Children swimming in Shanghai
ranging between giant slides and small nooks, the reading area includes a series of curved, over-sized seating pieces, or ‘leisure couches’. the colorful pieces are scattered in a dotted carpet, inviting children to accomodate themselves to read. the designers intended them to represent waves, cradling the children in infinite seating positions. bookshelves are incorporated into both of the couch’s ends. looking up at the lights in the reading area, the round lampshades are meant to look like sprays of water splashing in the sky. towards the left and right ends of the reading area, kids and parents can access the swimming pool and the restaurant.
the swimming pool looks like a huge water tank surrounded by pastel pink arches. to one side of the swimming pool, there is a variety of small classrooms hosting a variety of DIY workshops for kids and on the other side there is a walkway and seats creating a rest and companion area for parents. the swimming pool’s light blue hue contrasts agains the pink space in a magical evnironment and the giant overhead water droplets add to the dramatic effect. the over-sized round droplets in the ceiling acting as lighting devices creating a light atmosphere where children can be easily monitored by their parents.
the window between the pool and the parents area play an important role in the space, allowing parents to watch their children swim and children to interact back. at the end of the corridor is the bath area divided into children and adults. huge flower chandeliers adorn the infant bath area providing eye-catching pieces in the space’s ceiling. while parents bathe their babies, the latter are distracted observing the intricate and colorful patterns inside the lamps, making the experience easier for the parents. going back from the pool to the reading area, towards the right side of it, guests can access the dining area.
the ‘eggshells castle’ is the centerpiece of the restaurant that defies all senses of space and place, of sizes and heights and playful geometries. the mirrored ceiling gives the room an endless horizon, reflecting the busy and colorful interior. children are invited to play inside the eggs, or climb up and over them, encouraging guests them to experience the space in a playful way. the fairy-tale shapes welcome children and adults alike into this wonderland, hosting the dining tables around the eggshell castle so parents can keep track of their children.
other parts of the project take guests through maze-like hallways, clad with mirrors and a terrazo-style carpet, creating the illusion of being lost in an alice in wonderland scene. the party room’s fun chandeliers remind viewers of christmas ornaments and circus decorations in pastel tones that bring back childhood memories. the project’s overall color palette is a pastel range of pinks, blues and neutrals, disregarding color in gender intentionally. the colorful shapes in the interiors also include thin, black lines that add an avant-garde aesthetic to the project.
Oklahoma Energy Resources Board is hosting a teacher training workshop 8 p.m. Oct. 12 at Kingfisher High School, introducing educators to board-established energy curricula and how to apply it in the classroom.Teacher training for early years or nursery education
It's free to attend and those who do will be gifted a free kit of supplies, valued up to $1,100, plus a teacher's guide and a stipend, according to an OERB release.Teachers also will be eligible for a free field trip every year they teach OERB curricula to their students, the release said.
OERB, which is funded by oil and natural gas companies and royalty owners, will have "OERB master teachers" at the workshop to introduce the curricula to attendees and demonstrate lessons and experiments.
Established in 1993 as a result of the Oklahoma Energy Education and Marketing Act, education is a primary goal of OERB, in addition to well site cleanup and restoration.Since establishment, it has spent $14 million teaching its energy curricula throughout the state, and $4.2 million providing field trips.