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Adapalene is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Adapalene has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Check the label on the medicine for exact dosing instructions.Adapalene may cause drowsiness and dizziness.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Adapalene and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Adapalene had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.

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Adapalene is well absorbed orally with an absolute bioavailability of 75%. Adapalene has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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In general, both enantiomers of Adapalene and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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