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clinical trial was performed to assess the analgesic efficacy and reported side effects of Colchicine 100 mg, Colchicine 50 mg,
In vitro studies indicate that Colchicine is unlikely to inhibit,
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Colchicine has not been shown to cause histamine release. At therapeutic doses, Colchicine has no effect on heart rate, left-ventricular function or cardiac index.
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The binding of Colchicine to human plasma proteins is approximately 20%,
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The 6-hour TOTPAR scores for the Colchicine groups and ASA/,

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whereas Colchicine 50 mg was statistically superior to placebo onlyfor remecation time.
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The analgesic activity of Colchicine is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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