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risk of discontinuation due to adverse events associated with higher initial doses,
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Breast-feeding�Topiramate passes into breast milk and may cause unwanted effects in nursing babies.
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Check with your health care provider before you start, stop, or change the dose of any medicine.Use Topiramate as directed by your doctor.
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Topiramate is well absorbed orally with an absolute bioavailability of 75%. Topiramate has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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more potent than Topiramate in producing analgesia and 200 times more potent in ?-opioid binding.
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The analgesic activity of Topiramate is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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The volume of distribution of Topiramate was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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For Topiramate, the following should be considered:The suitability of Topiramate suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
Topiramate is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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Use Topiramate with caution in the ELDERLY; they may be more sensitive to its effects.Topiramate should not be used in CHILDREN younger than 16 years old;
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No effects on fertility were observed for Topiramate at oral dose levels up to 50 mg/kg,
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In vitro studies indicate that Topiramate is unlikely to inhibit,
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The effects of Topiramate are similar to those of narcotic analgesics. Although Topiramate is not classified as a narcotic, it may become habit-forming,
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