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How does Premarin work? What will it do for me?Premarin can cause side effects that may impair your thinking or reactions.
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Premarin is a centrally acting synthetic opioid analgesic.
When used for long periods of time or at high doses,
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Premarin may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
It is slightly soluble in water and freely soluble in alcohol,
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Premarin 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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Premarin is found in breast milk. Do not breast-feed while taking Premarin .When used for long periods of time or at high doses,
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The volume of distribution of Premarin was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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For Premarin, the following should be considered:The suitability of Premarin.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Premarin is rapidly and almost completely absorbed after oral administration.
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The effects of Premarin are similar to those of narcotic analgesics. Although Premarin is not classified as a narcotic, it may become habit-forming,
Premarin had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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the rates of withdrawals due to adverse events appeared to be higher in the Premarin groups.
the rates of withdrawals due to adverse events appeared to be higher in the Premarin groups.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Premarin and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Premarin is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Premarin is well absorbed orally with an absolute bioavailability of 75%. Premarin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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The binding of Premarin to human plasma proteins is approximately 20%,
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Premarin increases the risk of CNS and respiratory depression in these patients.
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