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Dr. Armand Balboni, CEO of Appili Therapeutics has announced that his company is working with FUJIFILM Toyama Chemical on its favipiravir treatment, which is approved in Japan as an antiviral drug, on a new front for the drug — the global search for a pandemic treatment that can both prevent and treat COVID-19.To get more news about Favipiravir, wisepowder official website is the best place for you.

Appili Therapeutics will sponsor the first clinical trial, phase 2, evaluating favipiravir for the prevention of COVID-19, as it has shown early efficacy against this disease. Appili is working with Canadian government agencies and infectious disease specialists to conduct the clinical trial at multiple long-term care facilities across Ontario.

Dr. Balboni worked with the drug when he was with the US department of defense and with the FDA during the pandemic flu and Ebola outbreaks. The treatment is administered orally, and not by injection, making it easier on patients.
The last decisive Russian Ministry of Health-approved clinical trial included 330 patients and is led by I.M. Sechenov First Moscow State Medical University, Lomonosov Moscow State University and other centers. Based on recent news out of Russia, after just ten days into the study the drug evidenced safety with no new side effects or adverse events.
The drug has showed a median cut of the median duration of the illness by over half from 9-days with standard therapy down to 4-day with the investigational drug Avifavir. With an 80% efficacy and evidence of high antiviral effect, Kirill Dmitriev, CEO of the Russian Direct Investment Fund (RDIF), reported, “It was developed and tested in clinical trials in Russia in an unprecedented short period of time, enabling Avifavir to become the first registered drug based on Favipiravir in the world.”
A review of Clinicaltrials.gov reveals at least 20 ongoing or planned clinical trials involving the use of Favipiravir in association with COVID-19 patients.

The 3-o-ethyl ascorbic acid (86404-04-8) is manufactured through purification and separation of 3-O-alkyl ascorbyl, each using-step process from the Vitamin C. This manufacturing method comprises of different steps such as reacting vitamin C, which is a base and an alkylating agent to synthesize 3-O-alkyl ascorbyl ether. The process also involves recovering the reaction solvent, ending the reaction, diluting residue using water, and applying anion exchange resin. The ion-exchanged column is then cleaned with a dilute acid, which combines the emission containing the 3-O-alkyl ascorbate. Once the elution is completed, the eluate is concentrated with pressure and then crystallized to produce purified 3-O-alkylascorbic acid ether.To get more news about ethylated ascorbic acid research, wisepowder official website is the best place for you.

The invention uses the separation method of ion-exchange to avoid using a large amount of flammable organic solvent. The process is safe, and delivers quality purification and separation effect as well as being cost-efficient. Some companies might have different methods of developing 3-O-ethyl-L-ascorbic acid, but separation and purification is the most common process used to manufacture the supplement. Ethylated ascorbic acid research shows that the drug can deliver quality results, primarily when used to improve skin health. For instance, the compound serves as an excellent supplement for boosting melanin formation and enhancing collagen synthesis to enhance cell repair. On the other hand, the supplement also helps in making your skin smooth, elastic, and in removing black spots as well.

Sesamol (533-31-3), which is also referred to by industrial users as Sesamol 533-31-3 or 3,4-(Methylenedioxy)phenol, is one of the lignan compounds which are extracted from roasted sesame oil. Besides the sesame phenol, other lignan compound extracts of the oil are sesamin and sesamolin.To get more news about Sesamol, wisepowder official website is the best place for you.

Sesamol is an phenolic antioxidant compound that has been played a very significant role in the medical field as it’s been found to have properties that can be used in cancer treatment. This compound is soluble in water and is characterized by a remarkable oxidant capacity.

Because of its strong oxidation properties, sesamol 533-31-3 is popularly used as an oxidant in treatment drugs as well as foods. In the healthcare field, particularly pharmaceutical synthesis, the compound is used as a starting material in the production of drugs that are used for treating hypertension as well as cardiovascular medicines.

Also, sesamol phenol can also be used as a raw material in the manufacturing of a pesticide called piperonyl butyl ether.

Jun 17 '20 · 0 comments · Tags: what is sesamol?

As an anti-cancer agent, red pigment lycopene works to suppress phosphorylation of p53 proteins. The compound regulates the gap-junction communication and cell replication at the G0-G1 phase. A particular study proposes that dietary Lycopene induces the modulation of cytochrome P450 2E1, which offers protection against carcinogenic lesions.To get more news about lycopene benefits, wisepowder official website is the best place for you.

Lycopene supplement controls cellular proliferation and potent mitogens in certain cancer cell lines. It regulates the differentiation of T-cells, hence suppressing the growth of mammary tumors.

Lycopene for prostate prevents carcinogenesis in several organs by eliminating oxidation levels of cellular biomolecules such as DNA, lipoproteins, lipids, and proteins. When a test was done to patients with prostate cancer, the researchers established that the subject group had low lycopene levels in the serum. Besides, oxidative stress was high in lipids and proteins.

Jun 17 '20 · 0 comments · Tags: how does lycopene work

Although the studies and Centrophenoxine history is over 50 years long, still there are some debates about how exactly the drug works. However, almost all studies are in agreement about the results this drug provides to the users.To get more news about anti-aging compounds, cofttek official website is the best place for you.

There is enough proof that Centrophenoxine is an acetylcholine precursor, which means that the drug helps in improving the acetylcholine levels in your body, which enhances cognitive performance and ability. No one doubts the Centrophenoxine benefits to your brain. However, the debate is about the pathway the drug uses to deliver the effects. Two theories are used to justify how this nootropic works.

One theory argues that once you take your Centrophenoxine dosage, the drug gets converted into phospholipid, which helps in boosting acetylcholine production in the body system. On the other hand, the second theory states that Centrophenoxine breaks down into choline in your brain and improve acetylcholine.

Leaving alone the debate on which pathway is right, the fact remains that cholinergic activities initiated by this drug are responsible for the all cognitive improvements the users’ experience after taking the proper Centrophenoxine dosage. This nootropic also improves the oxygen intake in your brain to enable better blood flow, which in turn enhances mental energy levels.

Centrophenoxine comes with a smooth transition from blood to the brain, and it acts as an oxidant. Therefore, your brain will be protected from the free radicals and all toxins with adverse effects on your brain are also flashed away. As a result, your brain cells will get proper support which automatically enhancers the organ functioning ability.
Primarily, Centrophenoxine brain effects are majorly performed by Dimethyl-aminoethanol (DMAE). However, as said earlier pCPA is used to help DMAE to go through the blood-brain barrier. Therefore, in the composition of Centrophenoxine, DMAE plays a significant role and has the following effects in your brain;

Increases Acetylcholine
Enhances blood flow and oxygen through the brain
Increases the protein level turnover in neurons
Decreases lipofuscin
Improves glucose uptake
Helps in removing free radicals by boosting antioxidant levels.
These are almost all functions performed by this nootropic. That means DMAE is the most vital component in this drug. The DMAE alone might not deliver any results as it cannot break the blood-brain barrier to get into your brain. Its combination with pCPA, therefore, makes Centrophenoxine a reliable and a potent ‘smart drug.’ Centrophenoxine vs DMAE, therefore, should not be an issue as the DMAE is part of the components that make this drug effective in promoting brain health.

Jun 8 '20 · 0 comments · Tags: anti-aging compounds

So far, Phosphatidylserine has undergone extensive research indicating that it works through the nerve cell membranes. It assists in the optimization of the functions of the cell, including homeostatic, maintenance, and specialized processes that are unique to the nerve cell.To get more news about phosphatidylserine nootropic stack, cofttek official website is the best place for you.

Phosphatidylserine and other phospholipids help in holding the cell membranes together. They are packed side to side, forming a two-layer structure that holds proteins and other membrane constituents in place. Studies done on rodents showed that Phosphatidylserine works by;

Rejuvenating adaptive behaviors, including learning.
It improves glucose utilization and synaptic efficiency in the body.
Reversal of the EEG patterns.
Works by reversing the nerve network decline.
It boosts the nerve transmitters, i.e., acetyl-choline, tyrosine hydroxylase activity, dopamine release, and catecholamine turnover.
It resets lagging circadian and estrus rhythms.
Phosphatidylserine is usually present in every cell type, and although it has proven to work best in the nerve cells, it also helps in improving one’s immunity. That is by facilitating the recycling of old cells. Usually, red blood cells become less rigid, and this makes them incapable of passing through the narrow capillaries, making them need replacement.

Consequently, membrane enzymes transfer Phosphatidylserine from its normal position, which is the inner half of the membrane to the outer half. That acts as a signal to the circulating immune cells to get rid of the aged red blood cells from circulation.

Phosphatidylserine has also been linked with membrane phenomena which are involved in the bone matrix formation, signal transduction in the heart, testicular function and secretion by the adrenal glands.

Primarily, magnesium L-threonate work is to increase magnesium levels in your body system and help in improving your overall cell and organs functioning. As mentioned earlier, magnesium plays a vital role to aid the proper functioning of your body cells.To get more news about Magnesium L-threonate reviews, cofttek official website is the best place for you.

Magnesium mineral is available in various day to day foods that you take almost daily. However, sometimes the mineral levels might go down and expose you to different health conditions. For instance, low magnesium levels can lead to mood problems, depression, anxiety, heart palpitations, headaches, and migraine. Athletes also suffer from muscle cramps and twitches when they lack enough magnesium in their body systems.

On top of the healthy magnesium available on your meals, if the mineral is not enough to facilitate the proper functioning of your cells and organs, then your doctor might prescribe Magnesium L-threonate. Human bodies are different, and therefore, not everyone will experience similar problems when they are suffering from magnesium deficiency. However, Magnesium L-threonate has proven to be a potent magnesium boosting supplement. Depending on your level of magnesium deficiency, Magnesium L-threonate delivers significant benefits when used correctly.

Once you take your Magnesium L-threonate dosage, the drug gets absorbed in your body system quickly and starts working almost immediately. Sufficient magnesium in your body results to improved cognitive function and memory, enhance the proper functioning of body muscles and nerves as well as boosting other body parts adequate functioning. In your stomach, magnesium mineral plays a vital role in neutralizing stomach acids and facilitate the movement of stools through the intestines.

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