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Jewelry stores on Long Island
Long Island is a virtual (rock) Candy Land when it comes to jewelry stores and, wow, do they run the gamut.
There are "the royals," where offerings can fall into that mega bling, knock your socks off, movie star, red carpet category some of it worth millions. On the opposite side of the spectrum are the more homespun types in which art and heart collide, and you can find one of a kinders that won't ravage your pocketbook. And then, there's so much in between.
Across the board, however, the best stores strive toward one goal: to make you happy. (And there is something about jewelry that does that, isn't there?) Have a look at a few of our favorites.
Joseph Maio, owner of this small, glamorous jewelry gallery, considers himself a curator of sorts, handpicking each piece of jewelry on display. About 25 designers range from better known types such as Gurhan to up and coming artists.
Prices range from $200 to $6,000, and there is a hip, graphic vibe to the merchandise such as a stop you in your tracks cuff of faceted oval green amethyst with a lemon quartz center (at $1,150, it's a high impact piece). Recently, Maio added some good costume jewelry to the mix a little less pricey, but a whole lot of fun, including bold funky chandelier earrings that run about $65.
There's plenty to buy at this earthy meets glam boutique with huge windows that let the sunshine in and high walls displaying large canvases painted by owner Glenn Bradford's wife, Sharyne, a fine artist.
Bradford is a spiritual sort who is more than happy to take customers on a sentimental journey via jewelry. Lockets of his own design tell a grandmother's story in tiny letters, or a charming bracelet marks the birth date of a child.
His signature logo, a graceful swirl, which he often uses as a clasp, represents "forever," and his specialty is love cartier ring replica the reinvention of old jewelry. He delights in magically transforming an outr piece into something spectacular.
More on Glenn Bradford Fine Jewelry
1870 E. imitation cartier love ring Jericho Tpke., Huntington
Find watches galore at this 33 replica cartier trinity ring year old jewelry emporium owned by husband and wife team Louis and Laura Maddaloni, who have developed a large following for their unusual collection of luxury timepieces, including Ulysse Nardins and Glashutte Original exquisite but pricey, some in the million dollar range. Laura Maddaloni calls the 4,000 square foot store "eclectic classic with a touch of funkiness. We focus on trends in fashion and jewelry." Swoon worthy: Luca Carati's "crazy gorgeous" stylized pieces of colored (white, Cognac and black) diamonds, and Michael M. engagement rings, which, says Maddaloni, are all the rage.
New additions to cartier jewelry replica the store include MICHELE Watches diamond encrusted fine watches with a touch of Miami Art Deco aesthetic and Tag Heuer luxury sport watches donned by the likes of President Barack Obama and actor Matt Damon.
7945 Jericho Tpke. Woodbury
Fashion and jewelry combust at this Long Island go to. At the classic European style, 4,000 square foot store, "You're always in for a surprise," says co president Lauren Kulchinsky. Every case "has a story to tell," and "features at least five pieces your mother always said you should have with a major twist." Take Kulchinsky's own not so classic strand of pearls Baroque South Sea pearls that hang down to her waist. And speaking of pearls, Mayfair has a $1 million strand ("The largest strand on record," says Kulchinsky), which took 10 years to put together.
Among the store's breakout stars is Kristen Farrell, whose medieval inspired romantic collection ($1,800 to $500,000) is a favorite of Bethenny Frankel (Farrell designed Frankel's famously reality show hyped engagement ring and wedding bands) and Gwyneth Paltrow. There's a bridal bar where big white diamonds are in vogue along with fancy pink varieties. Find Charriol cable jewelry with diamonds, starting at $290, great watches including Perrelet beloved by musicians and rock stars, and an astounding collection of opals fire, jelly, water. "It's not only about what's happening in jewelry. That's changed, and fashion is equally important," says Kulchinsky, who attends Fashion Week in New York and Europe. "My clients feel like they hired a jewelry stylist when they come here."
65 Middle Neck Rd., Great Neck
Tucked into this European style stucco building is Viggi Arbusman, this jewelry family matriarch who is known for her good taste, fantastical design and charm. She is an enchantress who, within minutes, will know everything about you, your family and the pricey piece you've long dreamed about.
The diminutive, 5 foot 1 Viggi says, "I hate when people say they can't carry something. I like big." And it's all there, including million dollar plus diamonds, dramatic pearl necklaces, a massive collection of pink diamonds she's only too happy to trot out, and even handsome silver cuff links that run a few hundred dollars. As for the card table in the window? Customers become friends and you can often find a group there after hours playing bridge.
29 Rocky Point Yaphank Rd. (Suite 3), Rocky Point and 137 Main St., Stony Brook
Owner Anthony Bongiovanni Jr. likes to promote a warm family atmosphere at his two stores. Find Pandora jewelry to pricey Lazare Kaplan engagement rings, Mikimoto pearls, estate jewelry and a good selection of watches, including several varieties of pocket watches, some vintage. Bongiovanni doesn't market through e mail. "We do things the old fashioned way, by phone or by writing a letter." Along with that, says Bongiovanni, comes unparalleled service. "We bend over backwards."
More on Rocky Point Jewelers (Rocky Point)
More on Rocky Point Jewelers (Stony Brook)
Keith Inc. Jewelry Design Gallery
You may walk into this shop and find store owner and jewelry designer Keith Fishenfeld blasting his saxophone at full throttle. He's a professional musician and bandleader, and often hosts gigs after hours here.
Fishenfeld, who was, he says, a prototype designer for Cartier and Tiffany Company at one time, defines himself as a "conceptual interpreter" and says his "musical improvisation" relates to his design. "I try to connect with people's personalities and their individualities."
His gold lily pad pieces set with pearls are particularly stunning, and lots of his work has an architectural bent.
The 550 square foot store is pleasantly hodgepodge with inventory that includes estate and vintage jewelry (starting at $150 for a small silver pin) to a ruby, diamond and sapphire handmade cigar band ring for $25,000.classic fake cartier pink gold bracelet stainless steel You deserve it Let us come aware in concern of it detailed
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Long Island is a virtual (rock) Candy Land when it comes to jewelry stores and, wow, do they run the gamut.
There are "the royals," where offerings can fall into that mega bling, knock your socks off, movie star, red carpet category some of it worth millions. On the opposite side of the spectrum are the more homespun types in which art and heart collide, and you can find one of a kinders that won't ravage your pocketbook. And then, there's so much in between.
Across the board, however, the best stores strive toward one goal: to make you happy. (And there is something about jewelry that does that, isn't there?) Have a look at a few of our favorites.
Joseph Maio, owner of this small, glamorous jewelry gallery, considers himself a curator of sorts, handpicking each piece of jewelry on display. About 25 designers range from better known types such as Gurhan to up and coming artists.
Prices range from $200 to $6,000, and there is a hip, graphic vibe to the merchandise such as a stop you in your tracks cuff of faceted oval green amethyst with a lemon quartz center (at $1,150, it's a high impact piece). Recently, Maio added some good costume jewelry to the mix a little less pricey, but a whole lot of fun, including bold funky chandelier earrings that run about $65.
There's plenty to buy at this earthy meets glam boutique with huge windows that let the sunshine in and high walls displaying large canvases painted by owner Glenn Bradford's wife, Sharyne, a fine artist.
Bradford is a spiritual sort who is more than happy to take customers on a sentimental journey via jewelry. Lockets of his own design tell a grandmother's story in tiny letters, or a charming bracelet marks the birth date of a child.
His signature logo, a graceful swirl, which he often uses as a clasp, represents "forever," and his specialty is love cartier ring replica the reinvention of old jewelry. He delights in magically transforming an outr piece into something spectacular.
More on Glenn Bradford Fine Jewelry
1870 E. imitation cartier love ring Jericho Tpke., Huntington
Find watches galore at this 33 replica cartier trinity ring year old jewelry emporium owned by husband and wife team Louis and Laura Maddaloni, who have developed a large following for their unusual collection of luxury timepieces, including Ulysse Nardins and Glashutte Original exquisite but pricey, some in the million dollar range. Laura Maddaloni calls the 4,000 square foot store "eclectic classic with a touch of funkiness. We focus on trends in fashion and jewelry." Swoon worthy: Luca Carati's "crazy gorgeous" stylized pieces of colored (white, Cognac and black) diamonds, and Michael M. engagement rings, which, says Maddaloni, are all the rage.
New additions to cartier jewelry replica the store include MICHELE Watches diamond encrusted fine watches with a touch of Miami Art Deco aesthetic and Tag Heuer luxury sport watches donned by the likes of President Barack Obama and actor Matt Damon.
7945 Jericho Tpke. Woodbury
Fashion and jewelry combust at this Long Island go to. At the classic European style, 4,000 square foot store, "You're always in for a surprise," says co president Lauren Kulchinsky. Every case "has a story to tell," and "features at least five pieces your mother always said you should have with a major twist." Take Kulchinsky's own not so classic strand of pearls Baroque South Sea pearls that hang down to her waist. And speaking of pearls, Mayfair has a $1 million strand ("The largest strand on record," says Kulchinsky), which took 10 years to put together.
Among the store's breakout stars is Kristen Farrell, whose medieval inspired romantic collection ($1,800 to $500,000) is a favorite of Bethenny Frankel (Farrell designed Frankel's famously reality show hyped engagement ring and wedding bands) and Gwyneth Paltrow. There's a bridal bar where big white diamonds are in vogue along with fancy pink varieties. Find Charriol cable jewelry with diamonds, starting at $290, great watches including Perrelet beloved by musicians and rock stars, and an astounding collection of opals fire, jelly, water. "It's not only about what's happening in jewelry. That's changed, and fashion is equally important," says Kulchinsky, who attends Fashion Week in New York and Europe. "My clients feel like they hired a jewelry stylist when they come here."
65 Middle Neck Rd., Great Neck
Tucked into this European style stucco building is Viggi Arbusman, this jewelry family matriarch who is known for her good taste, fantastical design and charm. She is an enchantress who, within minutes, will know everything about you, your family and the pricey piece you've long dreamed about.
The diminutive, 5 foot 1 Viggi says, "I hate when people say they can't carry something. I like big." And it's all there, including million dollar plus diamonds, dramatic pearl necklaces, a massive collection of pink diamonds she's only too happy to trot out, and even handsome silver cuff links that run a few hundred dollars. As for the card table in the window? Customers become friends and you can often find a group there after hours playing bridge.
29 Rocky Point Yaphank Rd. (Suite 3), Rocky Point and 137 Main St., Stony Brook
Owner Anthony Bongiovanni Jr. likes to promote a warm family atmosphere at his two stores. Find Pandora jewelry to pricey Lazare Kaplan engagement rings, Mikimoto pearls, estate jewelry and a good selection of watches, including several varieties of pocket watches, some vintage. Bongiovanni doesn't market through e mail. "We do things the old fashioned way, by phone or by writing a letter." Along with that, says Bongiovanni, comes unparalleled service. "We bend over backwards."
More on Rocky Point Jewelers (Rocky Point)
More on Rocky Point Jewelers (Stony Brook)
Keith Inc. Jewelry Design Gallery
You may walk into this shop and find store owner and jewelry designer Keith Fishenfeld blasting his saxophone at full throttle. He's a professional musician and bandleader, and often hosts gigs after hours here.
Fishenfeld, who was, he says, a prototype designer for Cartier and Tiffany Company at one time, defines himself as a "conceptual interpreter" and says his "musical improvisation" relates to his design. "I try to connect with people's personalities and their individualities."
His gold lily pad pieces set with pearls are particularly stunning, and lots of his work has an architectural bent.
The 550 square foot store is pleasantly hodgepodge with inventory that includes estate and vintage jewelry (starting at $150 for a small silver pin) to a ruby, diamond and sapphire handmade cigar band ring for $25,000.
Phil Taylor and Raymond van Barneveld meet in the Premier League on Thursday
The Premier League's visit to the First Direct Arena in Leeds for Night Three includes the meeting of Collier de Chien hermes bracelet copy great rivals Phil Taylor and Raymond van Barneveld.
The Dutchman reached the semi finals of the PDC World Championship after a 5 3 win over Phil Taylor at Alexandra Palace in December and they will be reacquainted again for a 78th time when they clash in Yorkshire on Thursday night.
Premier League leader Taylor leads the head to head meetings 56 17 and four draws between the pair, Barney's 2007 World Championship win against Taylor the pick of the bunch for Van Barneveld.
'The Power' got his revenge with a 7 1 thumping in the 2009 final and also swept to victory over the man from Den Haag with semi final wins in 2012 and 2015.
But Van Barneveld is back playing blistering darts with four points from his opening two games and with Taylor having announced his plans to retire at the end of the season, their latest collision could unthinkably be their last ever.
WATCH: El Clasico of darts! The El Clasico of darts between Raymond van Barneveld and Phil Taylor is back in Leeds
Scottish rivals Gary Anderson and Peter Wright open a night which also features the all Dutch clash between Michael van Gerwen and fake hermes h bracelet Knockoff Jelle Klaasen, the meeting between Adrian Lewis and James Wade and Dave Chisnall's clash with Kim Huybrechts.
"It's the Premier League, you're playing the ten best players in the world and you can't afford to miss," said Huybrechts. "When you miss you lose, it's as simple as hermes H bracelet replica that.
"A draw was probably a fair result last week but I've got to keep fighting."
You can see all fake hermes H bracelet pink the action from the First Direct Arena in Leeds from 7pm on Sky Sports 1 HD. Grab a NOW TV Sky Sports Day Pass and watch Premier League Darts from Leeds on Thursday night for just No contract.
The Premier League's visit to the First Direct Arena in Leeds for Night Three includes the meeting of Collier de Chien hermes bracelet copy great rivals Phil Taylor and Raymond van Barneveld.
The Dutchman reached the semi finals of the PDC World Championship after a 5 3 win over Phil Taylor at Alexandra Palace in December and they will be reacquainted again for a 78th time when they clash in Yorkshire on Thursday night.
Premier League leader Taylor leads the head to head meetings 56 17 and four draws between the pair, Barney's 2007 World Championship win against Taylor the pick of the bunch for Van Barneveld.
'The Power' got his revenge with a 7 1 thumping in the 2009 final and also swept to victory over the man from Den Haag with semi final wins in 2012 and 2015.
But Van Barneveld is back playing blistering darts with four points from his opening two games and with Taylor having announced his plans to retire at the end of the season, their latest collision could unthinkably be their last ever.
WATCH: El Clasico of darts! The El Clasico of darts between Raymond van Barneveld and Phil Taylor is back in Leeds
Scottish rivals Gary Anderson and Peter Wright open a night which also features the all Dutch clash between Michael van Gerwen and fake hermes h bracelet Knockoff Jelle Klaasen, the meeting between Adrian Lewis and James Wade and Dave Chisnall's clash with Kim Huybrechts.
"It's the Premier League, you're playing the ten best players in the world and you can't afford to miss," said Huybrechts. "When you miss you lose, it's as simple as hermes H bracelet replica that.
"A draw was probably a fair result last week but I've got to keep fighting."
You can see all fake hermes H bracelet pink the action from the First Direct Arena in Leeds from 7pm on Sky Sports 1 HD. Grab a NOW TV Sky Sports Day Pass and watch Premier League Darts from Leeds on Thursday night for just No contract.
Olympic gold medalist Amy Van Dyken severs spine in accident
SCOTTSDALE, Ariz. Six time Olympic gold medalist swimmer Amy Van Dyken severed her spine in an all terrain vehicle accident over the weekend, and told emergency workers she could not move her toes or feel anything touching her legs.
The 46 year old swimmer, who goes by her married name Van Dyken Rouen, was injured Friday. She was airlifted to a hospital and had surgery to stabilize her spine.
A letter from the Van Dyken and Rouen families said she severed her spinal cord at the T11 vertebrae and that the broken vertebrae came within millimeters of rupturing her aorta.
A report by the Show Low Police Department said the ATV that Rouen was driving hit a curb in a restaurant parking lot and sent her over a drop off between 5 to 7 feet.
Rouen was found lying on the ground next to the ATV. She was strapped to a backboard and airlifted to Scottsdale Osborn Medical Center.
A witness said he saw Rouen launch over the curb and found her unresponsive when he arrived on the scene, the report said. Rouen was not wearing a helmet at the time.
Her husband, former Denver Broncos punter Tom Rouen, told police officers he had changed the throttle mechanism on the ATV from a thumb accelerator to a twist accelerator a few days before the accident, though wasn't sure if it was a factor in the accident.
He said his wife had not been drinking alcohol that evening. female athlete to win four gold medals in hermes bracelet sale replica a single games. She captured the 50 meter freestyle and 100 butterfly and also competed on the winning relay teams in the 400 free and 400 medley.
Four years later at Sydney, she added two more golds in the 400 free and 400 medley relays before retiring from hermes bracelet imitation competition.
In 2003, she was among numerous prominent athletes who testified before a grand jury investigating the BALCO doping scandal. Rouen never tested positive for performance enhancing drugs during her career.
"The USA Swimming family is devastated to learn of Amy Van Dyken's unfortunate accident this weekend," the organization said in a statement. "We're happy to hear that she escaped and is now in great care. That she is already 'acting like her typical spunky, boisterous, ebullient self' shows she's on a great path."
"Amy is a champion who has proven throughout her life that she is hermes mens bracelet imitation a fighter hermes mens bracelet fake who takes on challenges and comes out on top. We know Amy will tackle her rehabilitation with vigor and be back on her feet sooner rather than later," it said.
SCOTTSDALE, Ariz. Six time Olympic gold medalist swimmer Amy Van Dyken severed her spine in an all terrain vehicle accident over the weekend, and told emergency workers she could not move her toes or feel anything touching her legs.
The 46 year old swimmer, who goes by her married name Van Dyken Rouen, was injured Friday. She was airlifted to a hospital and had surgery to stabilize her spine.
A letter from the Van Dyken and Rouen families said she severed her spinal cord at the T11 vertebrae and that the broken vertebrae came within millimeters of rupturing her aorta.
A report by the Show Low Police Department said the ATV that Rouen was driving hit a curb in a restaurant parking lot and sent her over a drop off between 5 to 7 feet.
Rouen was found lying on the ground next to the ATV. She was strapped to a backboard and airlifted to Scottsdale Osborn Medical Center.
A witness said he saw Rouen launch over the curb and found her unresponsive when he arrived on the scene, the report said. Rouen was not wearing a helmet at the time.
Her husband, former Denver Broncos punter Tom Rouen, told police officers he had changed the throttle mechanism on the ATV from a thumb accelerator to a twist accelerator a few days before the accident, though wasn't sure if it was a factor in the accident.
He said his wife had not been drinking alcohol that evening. female athlete to win four gold medals in hermes bracelet sale replica a single games. She captured the 50 meter freestyle and 100 butterfly and also competed on the winning relay teams in the 400 free and 400 medley.
Four years later at Sydney, she added two more golds in the 400 free and 400 medley relays before retiring from hermes bracelet imitation competition.
In 2003, she was among numerous prominent athletes who testified before a grand jury investigating the BALCO doping scandal. Rouen never tested positive for performance enhancing drugs during her career.
"The USA Swimming family is devastated to learn of Amy Van Dyken's unfortunate accident this weekend," the organization said in a statement. "We're happy to hear that she escaped and is now in great care. That she is already 'acting like her typical spunky, boisterous, ebullient self' shows she's on a great path."
"Amy is a champion who has proven throughout her life that she is hermes mens bracelet imitation a fighter hermes mens bracelet fake who takes on challenges and comes out on top. We know Amy will tackle her rehabilitation with vigor and be back on her feet sooner rather than later," it said.
One in three older adults reports age discrimination
NEW YORK (Reuters Health) Many older adults report being discriminated against due to their age, according to a new study.
One third of British people in their 50s and above said they had experienced age discrimination, researchers reported in the journal Age and Ageing. That included being treated with less courtesy or getting poorer service at restaurants and hospitals.
"We know from other work that many older people feel that they are discriminated against," lead researcher Isla Rippon, from University College London, said.
But these rates were surprisingly high, she added.
"Perceived day to day discrimination can affect both physical and mental health," she told Reuters Health. Frequent perceived discrimination may be a chronic source of stress and build up over time, leading to social withdrawal and reluctance to go to the doctor, Rippon said. The current data come from responses in 2010 and 2011.
Participants rated how often they experienced five discriminatory situations: being treated with less respect, receiving poorer service than other people in restaurants and stores, receiving poorer service Knockoff hermes gold bracelet in hospitals, fake hermes H bracelet Black gold being treated as not clever and being threatened or harassed.
They also specified why they thought such discrimination had happened.
One third of all participants attributed fake hermes h bracelet Knockoff at least some of their perceived discrimination to age. That rose to 37 percent of those over age 65.
"About one third of the people report age discrimination in Europe and only about 17 percent report ethnic discrimination," Liat Ayalon, who studies older adults at the Bar Ilan University School of Social Work in Ramat Gan, Israel, said.
Ethnic discrimination tends to be studied more than age discrimination, she said, though that seems to be changing as the global population ages.
It's also important to keep in mind that perceived discrimination and actual discrimination can be two different things, Ayalon, who was not involved in the study, told Reuters Health in an email.
Older retired men with less money and more education were most likely to report age discrimination.
Better educated people may be more attuned to inequities and more likely to report discrimination of any kind, Rippon said.
Seventeen percent of all participants the highest proportion reported being treated with less respect because of their age. Less than five percent said they had experienced age related harassment.
"Of particular concern were the 10 percent of all respondents who felt that they had been discriminated (against) due to their age in health settings," Rippon said. "This provides further evidence for the existence of ageism in healthcare."
"For healthy, independent living people the effect (of age discrimination) on health will be indirect," Wim van den Heuvel said. A professor of care science imitation hermes bracelet sale at the University of Groningen, the Netherlands, he did not participate in the new research.
Most of the people in this study were living independently.
People experiencing, or thinking they are experiencing, discrimination may go out less, feel sad or less safe, withdraw or become depressed, van den Heuvel told Reuters Health.
For older people not living independently, discrimination could actually lead to poorer medical care, he said.
Because this study lines up with results from the European Union and United States, the general findings about perceived discrimination probably apply to most countries, Rippon said. But the links to specific social factors like education and wealth may not.
NEW YORK (Reuters Health) Many older adults report being discriminated against due to their age, according to a new study.
One third of British people in their 50s and above said they had experienced age discrimination, researchers reported in the journal Age and Ageing. That included being treated with less courtesy or getting poorer service at restaurants and hospitals.
"We know from other work that many older people feel that they are discriminated against," lead researcher Isla Rippon, from University College London, said.
But these rates were surprisingly high, she added.
"Perceived day to day discrimination can affect both physical and mental health," she told Reuters Health. Frequent perceived discrimination may be a chronic source of stress and build up over time, leading to social withdrawal and reluctance to go to the doctor, Rippon said. The current data come from responses in 2010 and 2011.
Participants rated how often they experienced five discriminatory situations: being treated with less respect, receiving poorer service than other people in restaurants and stores, receiving poorer service Knockoff hermes gold bracelet in hospitals, fake hermes H bracelet Black gold being treated as not clever and being threatened or harassed.
They also specified why they thought such discrimination had happened.
One third of all participants attributed fake hermes h bracelet Knockoff at least some of their perceived discrimination to age. That rose to 37 percent of those over age 65.
"About one third of the people report age discrimination in Europe and only about 17 percent report ethnic discrimination," Liat Ayalon, who studies older adults at the Bar Ilan University School of Social Work in Ramat Gan, Israel, said.
Ethnic discrimination tends to be studied more than age discrimination, she said, though that seems to be changing as the global population ages.
It's also important to keep in mind that perceived discrimination and actual discrimination can be two different things, Ayalon, who was not involved in the study, told Reuters Health in an email.
Older retired men with less money and more education were most likely to report age discrimination.
Better educated people may be more attuned to inequities and more likely to report discrimination of any kind, Rippon said.
Seventeen percent of all participants the highest proportion reported being treated with less respect because of their age. Less than five percent said they had experienced age related harassment.
"Of particular concern were the 10 percent of all respondents who felt that they had been discriminated (against) due to their age in health settings," Rippon said. "This provides further evidence for the existence of ageism in healthcare."
"For healthy, independent living people the effect (of age discrimination) on health will be indirect," Wim van den Heuvel said. A professor of care science imitation hermes bracelet sale at the University of Groningen, the Netherlands, he did not participate in the new research.
Most of the people in this study were living independently.
People experiencing, or thinking they are experiencing, discrimination may go out less, feel sad or less safe, withdraw or become depressed, van den Heuvel told Reuters Health.
For older people not living independently, discrimination could actually lead to poorer medical care, he said.
Because this study lines up with results from the European Union and United States, the general findings about perceived discrimination probably apply to most countries, Rippon said. But the links to specific social factors like education and wealth may not.
Mary Gauthier play
A: It's the fact that nobody sells records any more. So it's just not possible to make a sustainable living writing songs. They haven't figured out a way to replace that.
A: I get a lot of juice from what I take in, which is primarily books and movies. I read constantly, but I'm also a huge film fan. I get a lot of ideas from films. Not really specific story ideas, but more about areas of life I'd like to dive into in songwriting. And on a deeper layer, I get the thrust of what I want to write about from whatever I happen to be going through in my own life. In 2015, replica van cleef blue necklace my "Blackbirds" album was really moved forward by what happens to all of us in midlife the pain of losses in our life. I'm not interested in writing songs that don't speak to things I'm going through right now. I'd say our audiences basically look like us. They're in their 50s, probably. As a woman, talking about aging seems so taboo. I thought, 'That's where I want to go.' I mean, if you tell me there's something I'm not supposed to talk about, that's where I'm gonna go. It's very rewarding to me to write those songs because I felt I was hitting a vein of truth that is hard to write about but is so important to write about. I feel lucky because I can throw a guitar and CDs in a van and go play a gig. That's something that can't be digitally reproduced. One of the things about this show with Eliza and Mary and me is that the audiences seem to be really hungry for that experience. It's one thing to download music and even to buy a CD. But to sit in a dark room van cleef imitation clover necklace and hear stories and feel you're a part of something that is still pretty rare. I think that's why this show works, and I think that is why people like us are van cleef arpels necklace replica still working.
A: It's the fact that nobody sells records any more. So it's just not possible to make a sustainable living writing songs. They haven't figured out a way to replace that.
A: I get a lot of juice from what I take in, which is primarily books and movies. I read constantly, but I'm also a huge film fan. I get a lot of ideas from films. Not really specific story ideas, but more about areas of life I'd like to dive into in songwriting. And on a deeper layer, I get the thrust of what I want to write about from whatever I happen to be going through in my own life. In 2015, replica van cleef blue necklace my "Blackbirds" album was really moved forward by what happens to all of us in midlife the pain of losses in our life. I'm not interested in writing songs that don't speak to things I'm going through right now. I'd say our audiences basically look like us. They're in their 50s, probably. As a woman, talking about aging seems so taboo. I thought, 'That's where I want to go.' I mean, if you tell me there's something I'm not supposed to talk about, that's where I'm gonna go. It's very rewarding to me to write those songs because I felt I was hitting a vein of truth that is hard to write about but is so important to write about. I feel lucky because I can throw a guitar and CDs in a van and go play a gig. That's something that can't be digitally reproduced. One of the things about this show with Eliza and Mary and me is that the audiences seem to be really hungry for that experience. It's one thing to download music and even to buy a CD. But to sit in a dark room van cleef imitation clover necklace and hear stories and feel you're a part of something that is still pretty rare. I think that's why this show works, and I think that is why people like us are van cleef arpels necklace replica still working.
Minimal residual disease cells in AML patients have an apoptosis
Correspondence: Dr GJ Schuurhuis, Department of Hematology, VU University Medical Center, BR240, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
TO THE EDITOR
Relapse in acute myeloid leukemia is common and is thought to arise from minimal residual disease (MRD) cells surviving chemotherapy.1 Survival of MRD cells has been attributed to drug resistance mechanisms. Defects in apoptosis pathways are probably contributing significantly to resistance to a variety of chemotherapeutic agents. Despite an emerging knowledge of the regulatory mechanisms of apoptosis, Bcl 2 still stands at the top of the list of parameters that contribute to chemotherapeutic resistance. In AML, it has been shown that Bcl 2 is of independent prognostic significance. High Bcl 2 predicts failure to achieve complete remission2 and shorter overall survival.3
In this study the expression profile of Bcl 2 and Bcl 2 related proteins in MRD cells was determined to examine whether chemotherapy induced upregulation of an apoptosis resistant protein profile or selection of subpopulations with a high anti apoptosis protein profile occurs during chemotherapeutic treatment.
In all, 61 AML patients were enrolled in this study after informed consent. Fresh bone marrow (BM) aspirates were obtained at diagnosis (n=61), after first cycle of induction chemotherapy (n=22), second cycle of induction (n=15) and after postinduction cycle (n=10) of chemotherapy, at follow up (n=13), and at relapse (n=9). The median age was 54 years, 29 male and 32 female subjects distributed over RAEB t (5 ), M0 (5 ), M1 (7 ), M2 (14 ), M3 (2 ), M4 (12 ), M5 (10 ), M6 (3 ), unknown (3 ) according to the FAB classification. In toal, 11 normal BM (nBM) from healthy donors were included.
To enable the study of apoptosis related protein expression in MRD cells, we relied upon an intracellular flow cytometry method.4,5 Briefly, this method consists of two parts; firstly, patient specific leukemia associated phenotypes (LAPs) are determined at diagnosis followed by an intracellular procedure to detect the Bcl 2 related proteins in these cells. The LAP can then be used to detect MRD cells in follow up BM samples. Figure 1a shows an example of an AML patient with a cross lineage LAP. Gating on the LAP+ cells enables quantification of the apoptosis related proteins of these cells (Figure replica van cleef jewelry 1c). The mean Bcl 2 expression was significantly lower in nBM CD34+ cells (Bcl 2: 6.62.5, P=0.001). Also, Bcl xL (2.20.8) and Mcl 1 (6.83.3) were lower and Bax was higher quatrefoil necklace van cleef replica (5.74.0), although these differences were not significant. All this suggests that the majority of AML cases have an increased anti apoptosis protein profile potentially offering the leukemic cells a survival advantage under therapy. This was tested with the same analysis procedure as at diagnosis, but was now performed on the MRD cells from patients in CR. Pgp activity analysis6 was performed in 17/51 MRD samples, showing deviant Pgp activity in MRD cells as compared to normal CD34+ cells confirming the malignant origin of the MRD cells. Figure 1b shows the MRD cells in a BM sample after the second cycle of induction chemotherapy. Surprisingly, the Bcl 2 expression (Figure 1d) of the MRD cells had decreased from 48 to 13. Of interest, this value now is near the range of nBM (range: 3.6 Figures 1e show the Bcl 2 value of all measured samples. In particular samples with high Bcl 2 levels (Figure 1e) but also with intermediate Bcl 2 levels (Figure 1f) and even with Bcl 2 levels within the normal range (Figure 1g) show decreases in expression. Overall, it can be concluded that MRD cells have significantly lower Bcl 2 levels after chemotherapeutic treatment (cycle 1: P=0.01, cycle 2: P=0.0008, cycle 3: P=0.04) and at follow up (FU1: P=0.01 and FU2: P=0.01) than at diagnosis. In all cases gating was performed on CD45low/SSClow cells (a) AML blasts at diagnosis with a CD34+CD7+ LAP. (b) BM sample after the second cycle of chemotherapy from the AML patient of (a) with MRD cells identified by the LAP (CD34+CD7+). MRD cells are 0.25% of all BM cells. Such cells are not present in control BM samples. Gating on the LAP+ cells enables quantification of Bcl 2 (c) at diagnosis and (d) after second cycle of induction chemotherapy. (e Summary of Bcl 2 levels of AML patients in CR after first, second, third cycle of chemotherapy at follow up (FU1 and FU2) and at relapse. of nBM CD34+ cells and (g) within the range found in nBM CD34+ cells (h) Bcl 2 levels of patients not in CR (NCR) at time of BM aspiration after first replica van cleef blue necklace and second cycle of chemotherapy and at relapse.
Full figure and legend (206K)
In contrast, Bcl 2 levels from refractory patients showed no change after first (P=0.64) or second cycle (P=0.79) (Figure 1h).
Despite the fact that the MRD cells in CR were apoptosis sensitive as compared to diagnosis, they were able to survive chemotherapy resulting in some cases in relapse. Bcl 2 expression at relapse had again increased to the level comparable to diagnosis (no difference with diagnosis; P=0.69) after the described decrease in an MRD situation.
Two other anti apoptosis proteins Bcl xL and Mcl 1 and the proapoptotic protein Bax were also studied (Table 1). In summary, although less prominent compared to Bcl 2, in responding patients Bcl xL and Mcl 1 significantly decreased from the second cycle onwards (Table 1a), while no change was observed in refractory patients (Table 1b). Relapse samples had similar protein levels as at diagnosis. On the other hand, Bax showed an increased expression compared to diagnosis, reaching significance after the first cycle of chemotherapy in responding patients. This shows that the prominent results found for the anti apoptosis proteins are not the results of aspecific treatment related cellular changes.
Overall, our data show that MRD blasts do not have a more apoptosis resistant profile. Instead, when a complete remission is achieved, in the majority of patients MRD cells are apoptosis sensitive compared to diagnosis and remain apoptosis sensitive throughout the remission period. Only when patients do not reach a CR or when patients relapse, the leukemic blasts retain their diagnosis apoptosis protein profile. These unexpected results clearly show that neither chemotherapy induced upregulation of an apoptosis resistant protein profile nor selection of subpopulations with a high anti apoptosis protein profile occurs. It does however suggest that external factors likely regulate expression of apoptosis related proteins. Either AML BM stromal cells or AML blasts themselves may account for this. Pertinent to this is the observation of Milojkovic et al (Milojkovic D, Buggins AG, Devereux S, Thomas NSB, Mufti GJ. Blood 2002; 100: 556a, 2184) that AML tumor supernatants can inhibit apoptosis of malignant hematopoietic cells. Combined with our observation this might indicate that AML cells at diagnosis, in follow up situations of refractory patients and at relapse produce apoptosis regulating factors that affect neighbouring cells, while in a CR BM due to the very limited number of AML cells, production is ineffective. Such cells might however be affected by the BM stroma: Konopleva et al7 found that a stromal cell line was able to increase Bcl 2 expression in blasts of 5/11 AML patients. It may then be hypothesized that intact BM stroma from AML patients may induce upregulation of anti apoptosis profiles in intact stroma, while such may be impossible in damaged stroma, the latter in fact resembling the actual situation in remission BM after chemotherapy.
Correspondence: Dr GJ Schuurhuis, Department of Hematology, VU University Medical Center, BR240, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
TO THE EDITOR
Relapse in acute myeloid leukemia is common and is thought to arise from minimal residual disease (MRD) cells surviving chemotherapy.1 Survival of MRD cells has been attributed to drug resistance mechanisms. Defects in apoptosis pathways are probably contributing significantly to resistance to a variety of chemotherapeutic agents. Despite an emerging knowledge of the regulatory mechanisms of apoptosis, Bcl 2 still stands at the top of the list of parameters that contribute to chemotherapeutic resistance. In AML, it has been shown that Bcl 2 is of independent prognostic significance. High Bcl 2 predicts failure to achieve complete remission2 and shorter overall survival.3
In this study the expression profile of Bcl 2 and Bcl 2 related proteins in MRD cells was determined to examine whether chemotherapy induced upregulation of an apoptosis resistant protein profile or selection of subpopulations with a high anti apoptosis protein profile occurs during chemotherapeutic treatment.
In all, 61 AML patients were enrolled in this study after informed consent. Fresh bone marrow (BM) aspirates were obtained at diagnosis (n=61), after first cycle of induction chemotherapy (n=22), second cycle of induction (n=15) and after postinduction cycle (n=10) of chemotherapy, at follow up (n=13), and at relapse (n=9). The median age was 54 years, 29 male and 32 female subjects distributed over RAEB t (5 ), M0 (5 ), M1 (7 ), M2 (14 ), M3 (2 ), M4 (12 ), M5 (10 ), M6 (3 ), unknown (3 ) according to the FAB classification. In toal, 11 normal BM (nBM) from healthy donors were included.
To enable the study of apoptosis related protein expression in MRD cells, we relied upon an intracellular flow cytometry method.4,5 Briefly, this method consists of two parts; firstly, patient specific leukemia associated phenotypes (LAPs) are determined at diagnosis followed by an intracellular procedure to detect the Bcl 2 related proteins in these cells. The LAP can then be used to detect MRD cells in follow up BM samples. Figure 1a shows an example of an AML patient with a cross lineage LAP. Gating on the LAP+ cells enables quantification of the apoptosis related proteins of these cells (Figure replica van cleef jewelry 1c). The mean Bcl 2 expression was significantly lower in nBM CD34+ cells (Bcl 2: 6.62.5, P=0.001). Also, Bcl xL (2.20.8) and Mcl 1 (6.83.3) were lower and Bax was higher quatrefoil necklace van cleef replica (5.74.0), although these differences were not significant. All this suggests that the majority of AML cases have an increased anti apoptosis protein profile potentially offering the leukemic cells a survival advantage under therapy. This was tested with the same analysis procedure as at diagnosis, but was now performed on the MRD cells from patients in CR. Pgp activity analysis6 was performed in 17/51 MRD samples, showing deviant Pgp activity in MRD cells as compared to normal CD34+ cells confirming the malignant origin of the MRD cells. Figure 1b shows the MRD cells in a BM sample after the second cycle of induction chemotherapy. Surprisingly, the Bcl 2 expression (Figure 1d) of the MRD cells had decreased from 48 to 13. Of interest, this value now is near the range of nBM (range: 3.6 Figures 1e show the Bcl 2 value of all measured samples. In particular samples with high Bcl 2 levels (Figure 1e) but also with intermediate Bcl 2 levels (Figure 1f) and even with Bcl 2 levels within the normal range (Figure 1g) show decreases in expression. Overall, it can be concluded that MRD cells have significantly lower Bcl 2 levels after chemotherapeutic treatment (cycle 1: P=0.01, cycle 2: P=0.0008, cycle 3: P=0.04) and at follow up (FU1: P=0.01 and FU2: P=0.01) than at diagnosis. In all cases gating was performed on CD45low/SSClow cells (a) AML blasts at diagnosis with a CD34+CD7+ LAP. (b) BM sample after the second cycle of chemotherapy from the AML patient of (a) with MRD cells identified by the LAP (CD34+CD7+). MRD cells are 0.25% of all BM cells. Such cells are not present in control BM samples. Gating on the LAP+ cells enables quantification of Bcl 2 (c) at diagnosis and (d) after second cycle of induction chemotherapy. (e Summary of Bcl 2 levels of AML patients in CR after first, second, third cycle of chemotherapy at follow up (FU1 and FU2) and at relapse. of nBM CD34+ cells and (g) within the range found in nBM CD34+ cells (h) Bcl 2 levels of patients not in CR (NCR) at time of BM aspiration after first replica van cleef blue necklace and second cycle of chemotherapy and at relapse.
Full figure and legend (206K)
In contrast, Bcl 2 levels from refractory patients showed no change after first (P=0.64) or second cycle (P=0.79) (Figure 1h).
Despite the fact that the MRD cells in CR were apoptosis sensitive as compared to diagnosis, they were able to survive chemotherapy resulting in some cases in relapse. Bcl 2 expression at relapse had again increased to the level comparable to diagnosis (no difference with diagnosis; P=0.69) after the described decrease in an MRD situation.
Two other anti apoptosis proteins Bcl xL and Mcl 1 and the proapoptotic protein Bax were also studied (Table 1). In summary, although less prominent compared to Bcl 2, in responding patients Bcl xL and Mcl 1 significantly decreased from the second cycle onwards (Table 1a), while no change was observed in refractory patients (Table 1b). Relapse samples had similar protein levels as at diagnosis. On the other hand, Bax showed an increased expression compared to diagnosis, reaching significance after the first cycle of chemotherapy in responding patients. This shows that the prominent results found for the anti apoptosis proteins are not the results of aspecific treatment related cellular changes.
Overall, our data show that MRD blasts do not have a more apoptosis resistant profile. Instead, when a complete remission is achieved, in the majority of patients MRD cells are apoptosis sensitive compared to diagnosis and remain apoptosis sensitive throughout the remission period. Only when patients do not reach a CR or when patients relapse, the leukemic blasts retain their diagnosis apoptosis protein profile. These unexpected results clearly show that neither chemotherapy induced upregulation of an apoptosis resistant protein profile nor selection of subpopulations with a high anti apoptosis protein profile occurs. It does however suggest that external factors likely regulate expression of apoptosis related proteins. Either AML BM stromal cells or AML blasts themselves may account for this. Pertinent to this is the observation of Milojkovic et al (Milojkovic D, Buggins AG, Devereux S, Thomas NSB, Mufti GJ. Blood 2002; 100: 556a, 2184) that AML tumor supernatants can inhibit apoptosis of malignant hematopoietic cells. Combined with our observation this might indicate that AML cells at diagnosis, in follow up situations of refractory patients and at relapse produce apoptosis regulating factors that affect neighbouring cells, while in a CR BM due to the very limited number of AML cells, production is ineffective. Such cells might however be affected by the BM stroma: Konopleva et al7 found that a stromal cell line was able to increase Bcl 2 expression in blasts of 5/11 AML patients. It may then be hypothesized that intact BM stroma from AML patients may induce upregulation of anti apoptosis profiles in intact stroma, while such may be impossible in damaged stroma, the latter in fact resembling the actual situation in remission BM after chemotherapy.
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Nurse accused of killing seniors tended to them 'just prior to their deaths
SubscriptionsGo to the Subscriptions Centre to manage your:My ProfileNursing home patient records show former nurse Elizabeth Wettlaufer, accused of killing eight seniors in southwestern Ontario, tended to them "at or just prior to the time of their deaths," according to police allegations filed in court last fall but kept confidential until today.Officers say they came to that conclusion after parsing records obtained from long term care homes in Woodstock, copy hermes brecelet clic h Paris and London where Wettlaufer worked between 2007 and 2016, often as the nurse in charge on the night shift."It was confirmed that Beth Wettlaufer had direct care of each of the victims . at or just prior to the time of their deaths," says the police filing, a sworn statement investigators submitted to a judge in October to get a court order to obtain her education records.Sections of the heavily censored statement offer a glimpse of how officers looking into Wettlaufer arrived at the decision to charge her with eight counts of first degree murder, in an investigation that has largely remained cloaked in mystery and innuendo.New snippets of the document, which contains unproven allegations yet to be tested in court, were made public Thursday morning following an Ontario Superior Court judge's ruling. The Postmedia newspaper chain had been fighting to get the entire file unsealed.The newly released portions show police homed in on "insulin overdose" as a possible cause in the deaths of the eight seniors early in their investigation, questioning managers at two nursing homes where Wettlaufer worked about how they stored and tracked the medicine.Details of why police arrested and charged Wettlaufer, contained in an application for a production order, have been heavily redacted. (Amanda Margison/CBC)A manager at Caressant Care in Woodstock, where Wettlaufer was employed from 2007 to 2014 and where it's alleged she killed seven seniors, said the nursing home doesn't secure or monitor its stocks of insulin.She added that it would "never hermes clic clac bracelet replica be looked at as a cause of death" in a patient, according to a summary of her remarks revealed in the police statement.Another nursing home, Telfer Place in Paris, told investigators it doesn't track or control insulin hermes enamel h bracelet knock off either, the police statement says.Disciplined for medication errorsWettlaufer was fired from Caressant Care on March 31, 2014, but the police filing says she had been suspended four times before that for "medication related errors."Quoted portions of a dismissal letter from Wettlaufer's boss, Brenda Van Quaethem, say she was terminated because of a "serious" incident where she gave the wrong medication to an elderly patient."Although you have acknowledged this latest error, this is another incident in copy hermes h bracelet a pattern of behaviours that are placing residents at risk," Van Quaethem is quoted as writing.
SubscriptionsGo to the Subscriptions Centre to manage your:My ProfileNursing home patient records show former nurse Elizabeth Wettlaufer, accused of killing eight seniors in southwestern Ontario, tended to them "at or just prior to the time of their deaths," according to police allegations filed in court last fall but kept confidential until today.Officers say they came to that conclusion after parsing records obtained from long term care homes in Woodstock, copy hermes brecelet clic h Paris and London where Wettlaufer worked between 2007 and 2016, often as the nurse in charge on the night shift."It was confirmed that Beth Wettlaufer had direct care of each of the victims . at or just prior to the time of their deaths," says the police filing, a sworn statement investigators submitted to a judge in October to get a court order to obtain her education records.Sections of the heavily censored statement offer a glimpse of how officers looking into Wettlaufer arrived at the decision to charge her with eight counts of first degree murder, in an investigation that has largely remained cloaked in mystery and innuendo.New snippets of the document, which contains unproven allegations yet to be tested in court, were made public Thursday morning following an Ontario Superior Court judge's ruling. The Postmedia newspaper chain had been fighting to get the entire file unsealed.The newly released portions show police homed in on "insulin overdose" as a possible cause in the deaths of the eight seniors early in their investigation, questioning managers at two nursing homes where Wettlaufer worked about how they stored and tracked the medicine.Details of why police arrested and charged Wettlaufer, contained in an application for a production order, have been heavily redacted. (Amanda Margison/CBC)A manager at Caressant Care in Woodstock, where Wettlaufer was employed from 2007 to 2014 and where it's alleged she killed seven seniors, said the nursing home doesn't secure or monitor its stocks of insulin.She added that it would "never hermes clic clac bracelet replica be looked at as a cause of death" in a patient, according to a summary of her remarks revealed in the police statement.Another nursing home, Telfer Place in Paris, told investigators it doesn't track or control insulin hermes enamel h bracelet knock off either, the police statement says.Disciplined for medication errorsWettlaufer was fired from Caressant Care on March 31, 2014, but the police filing says she had been suspended four times before that for "medication related errors."Quoted portions of a dismissal letter from Wettlaufer's boss, Brenda Van Quaethem, say she was terminated because of a "serious" incident where she gave the wrong medication to an elderly patient."Although you have acknowledged this latest error, this is another incident in copy hermes h bracelet a pattern of behaviours that are placing residents at risk," Van Quaethem is quoted as writing.
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Plane crash at Wichita
WICHITA, Kan. A small plane lost power after takeoff and crashed into a flight training building while trying to return to a Kansas airport Thursday, killing at least four people, injuring at least five others and igniting a fire that sent up towering plumes of black smoke that could be seen for miles around Wichita, officials and witnesses said.
Only the replica hermes h bracelet pilot was on the plane. CBS Wichita affiliate KWCH TV reports that about 100 people were in the building at the time of the crash at Wichita Mid Continent Airport but most were safely evacuated. Four people remained unaccounted for hours after the crash, but hermes replica bracelets were later located.
Two sweeps of the building found no more victims, though officials cautioned that a small portion containing a simulator room had not been checked because of structural dangers from the crash. Special equipment was being brought to the site that would allow access to the remaining space.
Wichita Fire Marshal Brad Crisp assured onlookers the search would resume as soon as the building was stable.
"We understand that this is a very difficult time, especially for folks who have family members who are working out here and they don't know," Crisp said.
The crash was "not an intentional act," Wichita Police Deputy Chief John Speer said. "We are comfortable in saying this is an aviation accident."
Smoke billows from a building at Mid Continent Airport shortly after a twin turbo airplane crashed into a building, killing several people, including the pilot in Wichita, Kansas October 30, 2014.
One person was in serious condition at Via Christi Hospital St. Francis, another was in fair condition and three more who were treated and released, hospital spokeswoman Maria Loving told CBS News.
The plane, identified hermes bangle replica as a twin engine Beechcraft King Air, crashed into a building that FlightSafety International uses to train pilots to fly Cessna planes, company spokesman Steve Phillips said.
CBS News transportation safety analyst Mark Rosenker told CBS Radio News that the building is next to an FAA flight standards district office.
It appeared to strike the top of the building and ignite what Wichita Fire Chief Ronald D. Blackwell described as a "horrific" fire.
In comments late Thursday, National Transportation Safety Board investigator Leah Yeager said the pilot reported a left engine problem soon after takeoff.
Yeager said the plane was "flying low and slow before it entered a left turn," according to witness reports.
"It continued to turn left and then impacted the (FlightSafety) building," Yeager said.
Jeff Papacek, 39, of Wichita, said he saw a "giant fireball" as he was heading to his engineering job at Learjet, which has a testing facility at the airport. He said he didn't see the crash because there were too many buildings in the way, but he said hermes clic clac h bracelet replica the plane caught his attention beforehand.
"We are used to planes flying straight with the runway and this plane just didn't look like it was lined up and was way too low for the direction it was going," Papacek said, adding that he drove to the crash site to see what was happening and saw the building fire raging.
The crash did not appear to be significantly disrupting passenger traffic at the airport as planes could be seen taking off from other runways.
The crash is the latest in a string of incidents at the airport. In December, an avionics technician was arrested after a months long undercover sting when he allegedly tried to drive a van filled with inert explosives onto the tarmac in a plot prosecutors say was intended to kill as many people as possible. Then in January, an Oklahoma man rammed his pickup truck through a security gate at the airport. In September, the airport conducted a large scale disaster exercise featuring the mock crash of a 737 aircraft.
FBI spokeswoman Bridget Patton said it is "too early to rule anything out" about the cause of Thursday's crash and confirmed the FBI is assisting in the investigation, but stressed the agency's protocol is to respond to "any and all plane crashes at airports."
WICHITA, Kan. A small plane lost power after takeoff and crashed into a flight training building while trying to return to a Kansas airport Thursday, killing at least four people, injuring at least five others and igniting a fire that sent up towering plumes of black smoke that could be seen for miles around Wichita, officials and witnesses said.
Only the replica hermes h bracelet pilot was on the plane. CBS Wichita affiliate KWCH TV reports that about 100 people were in the building at the time of the crash at Wichita Mid Continent Airport but most were safely evacuated. Four people remained unaccounted for hours after the crash, but hermes replica bracelets were later located.
Two sweeps of the building found no more victims, though officials cautioned that a small portion containing a simulator room had not been checked because of structural dangers from the crash. Special equipment was being brought to the site that would allow access to the remaining space.
Wichita Fire Marshal Brad Crisp assured onlookers the search would resume as soon as the building was stable.
"We understand that this is a very difficult time, especially for folks who have family members who are working out here and they don't know," Crisp said.
The crash was "not an intentional act," Wichita Police Deputy Chief John Speer said. "We are comfortable in saying this is an aviation accident."
Smoke billows from a building at Mid Continent Airport shortly after a twin turbo airplane crashed into a building, killing several people, including the pilot in Wichita, Kansas October 30, 2014.
One person was in serious condition at Via Christi Hospital St. Francis, another was in fair condition and three more who were treated and released, hospital spokeswoman Maria Loving told CBS News.
The plane, identified hermes bangle replica as a twin engine Beechcraft King Air, crashed into a building that FlightSafety International uses to train pilots to fly Cessna planes, company spokesman Steve Phillips said.
CBS News transportation safety analyst Mark Rosenker told CBS Radio News that the building is next to an FAA flight standards district office.
It appeared to strike the top of the building and ignite what Wichita Fire Chief Ronald D. Blackwell described as a "horrific" fire.
In comments late Thursday, National Transportation Safety Board investigator Leah Yeager said the pilot reported a left engine problem soon after takeoff.
Yeager said the plane was "flying low and slow before it entered a left turn," according to witness reports.
"It continued to turn left and then impacted the (FlightSafety) building," Yeager said.
Jeff Papacek, 39, of Wichita, said he saw a "giant fireball" as he was heading to his engineering job at Learjet, which has a testing facility at the airport. He said he didn't see the crash because there were too many buildings in the way, but he said hermes clic clac h bracelet replica the plane caught his attention beforehand.
"We are used to planes flying straight with the runway and this plane just didn't look like it was lined up and was way too low for the direction it was going," Papacek said, adding that he drove to the crash site to see what was happening and saw the building fire raging.
The crash did not appear to be significantly disrupting passenger traffic at the airport as planes could be seen taking off from other runways.
The crash is the latest in a string of incidents at the airport. In December, an avionics technician was arrested after a months long undercover sting when he allegedly tried to drive a van filled with inert explosives onto the tarmac in a plot prosecutors say was intended to kill as many people as possible. Then in January, an Oklahoma man rammed his pickup truck through a security gate at the airport. In September, the airport conducted a large scale disaster exercise featuring the mock crash of a 737 aircraft.
FBI spokeswoman Bridget Patton said it is "too early to rule anything out" about the cause of Thursday's crash and confirmed the FBI is assisting in the investigation, but stressed the agency's protocol is to respond to "any and all plane crashes at airports."