Where it comes from: Yohimbe is derived from the bark of a west African evergreen tree. Yohimbine is an active chemical (an alkaloid) found in said bark and is cultivated into supplement form. Yohimbine hydrochloride is a standardized form of yohimbine that is available as a prescription drug in the United States. These terms are all related but are interchangeable.Yohimbine powder

What it’ll do for you: “Yohimbe dilates the blood vessels and can lower blood pressure,” says Dr. Patrick M. Fratellone, an integrated physician with a practice in Manhattan. “So experts figured, if it can do that, it must give you an erection and treat erectile dysfunction.” Some proponents say that yohimbe extracts are powerful antioxidants that can prevent heart attacks, act as a stimulant and an anti-depressant, and an aid to weight loss. Here, a closer look at the key benefits:

Treats erectile dysfunction: In some countries, the extract is used as a prescription drug to treat erectile dysfunction. A 2002 study in Germany found that pro-erectile effects of the bark extract may predominantly be caused by the yohimbe. But it’s unclear if the yohimbe is enough on its own to help.
Aids in fat loss: Yohimbe and other alkaloids in the bark extract are said to block specific receptors that actually inhibit fat loss Opens a New Window. . A three-week study in 1991 observed 20 obese females on 1,000-calorie diets. They were given 20 mg of yohimbe each day and lost three pounds more than the group receiving placebos. Not a drastic weight loss, but enough to give experts hope that yohimbe can help with weight loss. Other studies have found that yohimbe increases the amount of non-esterified fatty acids, a result of fat breaking down. More research is needed. Most other studies in the field are done using the drug yohimbine. Extracted chemicals are not the same as yohimbe bark. Studies with yohimbine are expected to give different results than studies that used the raw plant.
Suggested intake: “The problem with yohimbine is that you can’t regulate the amount in a dosage,” says Fratellone. “It all depends on what part of the tree it comes from, how it’s cultivated, how it’s exported, and so on. The amount of extract you get will vary.” FDA researchers analyzed a number of over-the-counter yohimbe bark products. They found that the supplements contained only seven percent or less of the amount of yohimbine that would be found in actual yohimbe bark, which suggests that they contained little or no yohimbe. However, the prescription form of yohimbine is strictly regulated by the FDA. It is approved only for the treatment of impotence, and is available in tablets and capsules. For erectile dysfunction, 5.4 to 10 milligrams three times daily has been studied and regarded as generally safe.

Associated risks/scrutiny: “A dose of yohimbine that’s too big could drop your blood pressure, cause dizziness, facial flushing and nausea,” warns Fratellone. Yohimbine and yohimbe bark may also increase heart rate and raise blood pressure. “No one should experiment with herbs without talking to their doctor,” reminds Fratellone. “If you’re taking Flomax and you start taking yohimbe, you’re going to dilate your penal vessels and you’ll pee more.” Other potential interactions between yohimbe and other drugs and herbs Opens a New Window. should be considered. Some of these combinations may be dangerous.

Yohimbe also is known as yohimbehe, and yohimbine. This tree grows throughout the African nations of Cameroon, Gabon, and Zaire. The alkaloid yohimbine also is obtained from Aspidosperma quebracho blanco and Rauwolfia serpentina.Yohimbine hydrochloride powder,Yohimbine HCL powder,Yohimbine powder

The bark of the West African yohimbe tree is rich in the alkaloid yohimbine, and both the crude bark and purified compound long have been hailed as aphrodisiacs. The bark has been smoked as a hallucinogen and has been used in traditional medicine to treat angina and hypertension.

Erectile dysfunction
Today, yohimbe is being investigated for the treatment of organic impotence, in particular patients with diabetes, and for use as an aphrodisiac. Yohimbe can cause dilation of peripheral blood vessels along with central nervous system stimulation. Therefore, the drug has been investigated for erectile dysfunction. Clinical studies do suggest that yohimbe may be effective in the treatment of male organic impotence.

One older prescription product (Afrodex, Bentex Pharmaceuticals) combined 5 mg each of yohimbine HCl, methyltestosterone, and nux vomica in a capsule for the treatment of male climacteric and impotence. Although a number of clinical trials were conducted with this product, the results generally were unimpressive. More recent investigations now strongly suggest that higher doses of the drug (6 mg three times a day) may be effective in the treatment of organically impotent men. A meta-analysis of clinical studies found yohimbe superior to placebo. All studies evaluated found a positive response to yohimbe and few side effects were reported.

Indicated for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance
100 mg PO once daily at bedtime.Flibanserin hydrochloride powder
Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression
Discontinued after 8 weeks if no improvement
Missed dose
If a dose is missed at bedtime, instruct the patient to take the next dose at bedtime on the next day
Instruct the patient to not double the next dose
CYP3A4 inhibitors
Coadministration with moderate or strong CYP3A4 inhibitors is contraindicated
If initiating flibanserin following moderate or strong CYP3A4 inhibitor use, start flibanserin 2 weeks after the last dose of the CYP3A4 inhibitor
If initiating a moderate or strong CYP3A4 inhibitor following flibanserin use, start the moderate or strong CYP3A4 inhibitor 2 days after the last dose of flibanserin

In the Fall of 2018, United Therapeutics (UTHR) and MannKind (MNKD) announced a deal for a "secret molecule" for PAH which would have MannKind doing some concept formulation work. Upon completion of that formulation work, United Therapeutics would make a decision on whether or not to move forward. If United does decide to move forward, two $15 million milestones and low double digit royalties (if FDA approved) would be on the table. What triggers the earnings of those milestones has not been disclosed by either company. Subsequent to the United and MannKind deal being announced, United Therapeutics had an interesting slide on the pipeline section of its website which likely gave a very large hint that the "secret molecule" was Adcirca (Tadalafil). At the time, I wrote an article speculating this fact, titled, "United Therapeutics Looks To Develop Inhaled Adcirca - A Deeper Look".tadalafil powder
The evidence strongly points to the "secret molecule" being Tadalafil:

The term "inhaled DPI" - stands for "Dry Powder Inhaler"
The only dry powder inhaler deal United Therapeutics has is with MannKind
PDE5 is a specific class of drug. The only PDE5 drug United Therapeutics has in its platform is Adcirca (which is Tadalafil)
The time-line of "medium-term launches" jives with the timing it would take to do the necessary formulation work and studies
Tadalafil is owned and controlled by Eli Lilly (ELY). Lilly markets Tadalafil under the name Cialis for the indication of Erectile Dysfunction. Lilly licensed Tadalafil to United Therapeutics for the indication of PAH. Lilly controls all pricing of the drug. Tadalafil has now gone generic, and there are already generic versions of Tadalafil on the market for both Adcirca and Cialis.

Many MannKind investors were very quick to jump to the idea that United Therapeutics and MannKind would move forward for an Erectile Dysfunction indication. The first thing to grasp is that the deal between United Therapeutics and MannKind does not include the indication of Erectile Dysfunction. Thus, MannKind retains 100% of the rights for such an indication. Before we put the cart before the horse, there is a lot of ground to cover.

Decision Point for United Therapeutics

MannKind has essentially stated that it is complete with the formulation study on the "secret molecule". This means that United Therapeutics is at a decision point. It is widely expected that this decision will be a Q3 event. The decision on whether or not to move forward is purely in MannKind hands.

Even if the formulation works, it is still not a slam dunk that United Therapeutics will move forward. United CEO Martine Rothblatt has a business decision to make. In other words, is investing another $30 million into MannKind worthwhile? Remember, Tadalafil has gone generic, and the only indication that United has rights to is for treating PAH.

In order to better assess the situation, we need to go back in time. In Q3 of 2018, Tadalafil was on the verge of going generic for both PAH as well as erectile dysfunction. United's sales of Adcirca in 2017 and 2018 were as follows:

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Fladrafinil Quick Details

Nandrolone laurate powder is also referred to as CRL-40,941 or fluorafinil. It is a wakefulness-promoting agent that is found in the eugeroic classification of drugs. Fladrafinil is closely related to adrafinil and modafinil. Though it's chemical composition and effects are very similar. Fladrafinil is capable of producing anti-aggressive effects while adrafinildoesn't have this ability. Fladrafinil increases cognitive function, motivation, and improves memory as it works on dopamine and histamine neurotransmitters in the brain.

Fladrafinil Benefits:

1. Fladrafinil Improves memory as it works on dopamine and histamine that are neurotransmitter in the brain

2. Fladrafinil Increases cognitive function since it boosts the working capacity of the brain when one is in an awkward situation.

3. Fladrafinil is used to treat insomnia and depression.

4. Fladrafinil promotes consciousness

5.Fladrafinil increases motivation, making one to do a lot of activities without exhaustion.
Fladrafinil Application in Improve short term memory

People have different capacities of retaining information therefore for those who find difficulty in retaining information, when they consume the drug, they will be able to retain more information for a few hours.
This can be helpful especially if one is facing exams that are proving difficult.Fluorafinil is a halogenic compound and has been identified as adrafini's bis(p-fluoro) ring substitute. As a fluorinated derivative, it has been described as more potent than adrafini.

Fladrafinil dosage

Fladrafinil is 3-4 more potent thanadrafinil. New users should start with 30-80 mgs within 14-16 hours daily, and anadrafinil moderate dose is between 30-100 mg per day. The dosage to be increased as the effects are being experienced as the body reacts towards the dose. Dosage should not exceed 200mgs per day.

Centrophenoxine is a member of the family of cholinergic nootropics. Produced synthetically, the compound is a precursor to DMAE (dimethylaminoethanol), which has been proven to improve cognitive function in seniors, especially those diagnosed with a degenerative brain disease like Alzheimer’s. [1]In a separate study, Centrophenoxine also helped improve brain stimulation and the formation of new long-term memories in the elderly population.However, its positive nootropic effects aren’t limited to seniors.
Younger users with healthy brains can also benefit from the enhanced cognitive functions and memory improvement.In addition to the cognitive benefits, Centrophenoxine is thought to have powerful anti-aging properties and has been shown to increase the lifespan in mice by 30-50% in a 2002 study. [2]The supplement can be purchased legally online or in stores at retailers throughout the US in either a powder or a pill form.Older adults with any sort of memory issues, including Alzheimer’s or dementia, as well as younger adults looking to improve their ability to form memories and learn new things can benefit from taking Centrophenoxine.

Centrophenoxine is a very popular supplement within the nootropics community, and based on the research there’s a good reason for it.It delivers similar cognitive enhancement properties to what you’ll see in Alpha GCP but stands apart with the research on the anti-aging and possible longevity-boosting properties. I’m very interested in additional studies and information as it becomes available.Another exciting observation of several online Centrophenoxine users is its ability to produce somewhat instant effects after a one-time use.
While other nootropics may offer similar effects over time, some users theorize that Centrophenoxine can produce lasting memory enhancement benefits after a single cycle of taking the product.
As centrophenoxine is a prodrug from DMAE, it enables the body to remove harmful molecules in the brain that would result in decreased cognitive function.Through its ability to suppress these molecules, centrophenoxine can not only slow down the mental sides of aging, but it can also work to actively reverse them.https://www.aasraw.com/products/nandrolone-phenylpropionate-powder

Coluracetam is a nootropic supplement

NPP powder is a nootropic supplement that is marketed as being able to enhance mental functioning. Nootropics are a class of supplements that have positive effects on the brain, such as relieving anxiety, enhancing cognitive abilities and boosting motivation.
Coluracetam (also known as MKC-231) is, as stated earlier, a nootropic supplement that is designed to boost mental function. It is in the class of nootropics called racetams, which all have similar effects on the brain and all share similar chemical structures.
1. Enhance mental intelligence.
2. Boost memory and leaning capabilities.
3. Improve brain power to solve problems and protect it from any chemical or physical injury.
4. Enhance motivation level.
5. Enhance the control of cortical/subcortical brain mechanism.
Specification: 98%
Appearance: White Off-white Crystalline Powder
CAS Number: 135463-81-9
Chemical Formula: C19H23N3O3
MOQ: 0.1KG
Normal Package: 1kg/Aluminum foil bag,25kg/Fiber drum
Normal Payment: T/T, L/C, Paypal, Western Union
Lead Time: 3~5 Days

Hi-Q Nootropics CRL-40,940 powder CAS:90280-13-0

Chemical Name: 2-[bis(4-fluorophenyl)methylsulfinyl]acetamide
Synonyms: Lauflumide, Fluoromodafinil, Flmodafinil, Bisfluoromodafinil, N-deshydroxyl Fladrafinil, bis-(p)-fluoromodafinil, (2-Amino-2-oxoethyl)[bis(4-fluorophenyl)methyl]sulfoniumolate.Nandrolone powder
CAS #: 90280-13-0

Eugeroic related to Modafinil. Weak Dopamine Reuptake Inhibitor (DRI). Psychotonic.

Form: White to pale cream powder.
Molecular Formula: C15H13F2NO3S

Molecular Weight: 309.33 g/mol

Solubility: Poorly soluble in water; poorly soluble in ethanol; Soluble to 1 mg / mL in isopropanol.

Product Description：

synonyms：BisfluoroModafinil

Formal Name： BisfluoroModafinil;FlModafinil;CRL-40,940

Formula C15H13F2NO3S

Molecular Weight: 309.33 g/mol

Purity ≥99%

CAS Number: 90280-13-0

SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)N)F

Application: CRL-40,940 (Fluoromodafinil) is an eugeroic related to and of higher potency than modafinil. Main active metabolite of Fladrafinil.

Appearance: White to pale cream powder

Physical State: Solid

Solubility: Poorly soluble in water; poorly soluble in ethanol; Soluble to 1 mg / mL in isopropanol.

Storage: Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.

Stability: Stable for at least two years when stored as above.

Other names：

Lauflumide, Fluoromodafinil, 2-[bis(4-fluorophenyl)methylsulfinyl]acetamide, Flmodafinil, Bisfluoromodafinil, bis-(p)-fluoromodafinil, N-deshydroxyl Fladrafinil, (2-Amino-2-oxoethyl)[bis(4-fluorophenyl)methyl]sulfoniumolate

History of CRL-40,940

Adrafinil and the related family of eugeroics including Modafinil, CRL-40,941 and CRL-40,940 were originally invented in the late 1970's as part of research carried out by the French Laboratoire L. Lafon, led by Dr. Michel Jouvet.

Two unauthorized health products have been seized by Health Canada from Next Level Fitness locations in Richmond and Surrey. The products were labelled to contain a prescription drug substance, called L-Dopa, that could pose serious health risks.Bromantane powder
The products are called:

Ballistic Laboratories – TRT (Testosterone Booster)
Freak N’ Muscle Inc- Freak’n Test (Testosterone Enhancer)
Both have the ingredient Mucuna Pruriens (L-Dopa).

Health Canada is warning anyone who may have used either of these two products and have health concerns to consult their doctor.

Anyone with a heart condition, high blood pressure or diabetes will be most at risk.

L-Dopa, which is also known as levodopa, may interact with drugs prescribed for high blood pressure and should not be used by pregnant women, or those who plan to become pregnant or are breastfeeding.

It should also not be taken by people with narrow angle glaucoma; untreated heart, liver, kidney, lung or hormonal diseases; a history of melanoma, or those who should not take drugs such as isoproterenol, amphetamines or epinephrine.
Some symptoms people experience while taking levodopa include uncontrollable movements of the face, eyelids, mouth, tongue, neck, arms, hands, or legs; severe or persistent nausea or vomiting; an irregular heartbeat or fluttering in the chest; feeling lightheaded when standing quickly, or unusual changes in mood or behaviour.
Health Canada warns that authorized health products have an eight-digit number on them with DIN, DIN-HM or NPN.

Never before had the judging panel unanimously decided to each invest millions of dollars into a potential company.After buying a staggering 25% share in the sisters' company, the Shark Tank panel have personally mentored the pair, helping them undergo re-branding and re-packing of their miracle product.Raw Cardarine powder

Touting their discovery as “the greatest step forward in weight-loss history,” the judges were quick to offer up their hard earned cash to back the entrepreneurial pair.“We were shocked. The most we were hoping for was some advice…we weren’t even sure that we would manage to get any investors,” explained Samantha.

After outstanding offers from each panel member, the sisters burst into tears.“It didn’t feel real. The fact that all these successful, business-minded people wanted to be a part of what we were doing and willing to invest their own money, it was very emotional!” explained Anna.

The pair are the first contestants in the show’s long duration to ever receive a standing ovation and offers of investment from all panel members. The sisters said they celebrated the success with champagne and cake when the episode wrapped.Since filming the show-stopping episode, the sisters have been hard at work putting the advice of their mentors into play.

“We completely re-branded our company and came up with new packaging,” said Anna.The pair recently unveiled the product that netted them millions of dollars in investments.

“The product we displayed on the show has been rebranded into Forskolin Green Vibe. It’s the original formula, all we’ve done is change the name and the packaging,” explained Samantha.

The sisters launched the product for sale through their company website and say they sold out within 5 minutes.“We even made sure we had more product than we thought we could sell, but all of it sold out within five minutes!” exclaimed Samantha.