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Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-alpha).

Palmitoylethanolamide (PEA), is a fatty acid amide, and is a naturally occurring substance within our bodies. Fatty acid amides are, as the name suggests, an amide formed from a fatty acid and an amine. Amines are a functional group that consist of a nitrogen atom in combination with three carbon atoms and/or hydrogen atoms. Fatty acid amides are vital to the chemical signaling processes within our bodies.Nootropics Powder
PEA is produced within our cells, and within the body it contributes to the homeostasis, or balance, of the body.

Palmitoylethanolamide is present in many bodily tissues and cells. It is essential in the protection of cells and tissue against harmful stimuli due to lack of oxygen, mechanical damage or damage due to inflammation. On top of that, palmitoylethanolamide is an anti-inflammatory that has been proven effective against flu and colds among others.
Pain relieverpalmitoylethanolamide is a good painkiller, specifically for chronic pain. Additional to pain relief it recently became clear that palmitoylethanolamide can relief anxiety and depression and showed an anti-epileptic effect in animal studies. Recently palmitoylethanolamide turned out to increase the immune cells capacity to destroy bacteria.
Palmitoylethanolamide (PEA) binds to nuclear receptors in cells and produces a variety of effects that help deal with chronic pain and inflammation. This is our bodies' way of battling these issues and it works rather well, since palmitoylethanolamide is a natural substance with no side-effects whatsoever. The problems occur when the pain is chronic,

since our bodies can't produce enough PEA. The help comes in the form of capsules containing PEA as a supplement. This is the perfect way to increase the amount of palmitoylethanolamide in your organism to help you deal with almost any kind of pain. Moreover, since it is basically a fatty acid amide, there is no way to overdose on it and having in mind that it has no side effects and that there have been no known issues that come from combining it with other medicine, PEA seems like the perfect choice for anyone experiencing any kind of pain.
Fever reducerUsing palmitoylethanolamide (PEA) is a way to deal with fevers that is as natural as the cause of fever itself. PEA has been known to relieve pain and have great anti-inflammatory effects, but it has been proven to stabilize the mast cells as well. These cells play an important role when it comes to hay fever and managing their operation can have extremely positive effects on reducing inflammation.
Higher concentrations of pollen in the air make the mast cells overly active and they produce substances that cause the symptoms of hay fever.
Hay fever is usually controlled by using antihistamine. However, they have very adverse side effects. PEA has no side effects; it can be given to children and there is virtually no way of overdosing. Moreover, palmitoylethanolamide can be used as prevention. This is very important as hay fever is a recurring condition whose timing can be estimated somewhat accurately, so taking PEA for prevention can completely remove problems with fever.
Anti-inflammatoryPalmitoylethanolamide can be found in our bodies as it is a natural compound that is used to reduce inflammation and pain. Ever since 1980s scientists have known about amazing anti-inflammatory effects of PEA. In about two decades before that there had been numerous studies that separated PEA from other anti-inflammatory treatment methods due to its fantastic effects and utter lack of side effects which makes it perfectly suitable for children as well.
One of the studies from 1975 published in The Lancet compared the effects of 3 g of aspirin a day to 1.8 g of PEA a day. The effects of both were noticeable improvements in join movement and reducing pain.
In early 1990s a Nobel prize winner Rita Levi-Montalcini and her team demonstrated the effects of palmitoylethanolamide on mast cells and their stabilization.

Aside from being an effective treatment for inflammation, palmitoylethanolamide can also be used to prevent inflammation in the first place. Moreover, using it as prevention bears no dangers whatsoever. Taking PEA has no side-effects and overdosing is virtually impossible.
Homeostasis regulatorThe brain uses a lot of energy and it is the place where many free radicals are formed. This can cause serious issues with nerve tissue and

palmitoylethanolamide may serve as the most natural and effective protection. The same goes for ischemia-reperfusion injury which has been known to occur after a stroke, as well as various acute damages that may affect the central nervous system.
Palmitoylethanolamide has this effect mostly due to its ability to bridge the gap between blood and nerves. It can at the same time provide protection for the nervous tissue and blood vessels and thus give complete defense for the entire system. Aside from reducing inflammation, PEA also re-establishes homeostasis levels of nitrotyrosine and iNOS.Immune system boosterEffects of palmitoylethanolamide for treating cold and flu are well documented. The same goes for battling fevers and any kind of inflammation. Its popularity is even more boosted by the fact that it has no ill effects and that it is completely natural. What is less familiar is the mechanism that lies behind this effectiveness.
Its importance became familiar in the 1970s after several double blind and placebo controlled studies. These proved that there are absolutely no side effects and that PEA can be used by senior patients and children alike.Allergies reducerWhen a person gets in contact with an allergen, their body makes antibodies and these antibodies attach themselves to mast cells. The next time the same person gets in touch with the same allergen, those mast cells release things like histamine and cytokines and they cause the all too familiar allergy symptoms that can make our days a living hell.
Moreover, mast cells are present all over the body, so the inflammatory elements can reach a wide variety of places inside our bodies. Palmitoylethanolamide has been very effective when it comes to stabilization of mast cells. Plus it affects mast cells wherever they are, since it can affect places as varying as blood and nerves.
NeuroprotectivePEA has had amazing effects when it comes to relieving problems for patients with MS pains and spasms, and also the ones with Parkinson's disease. Most of these problems have been treated with things like Valium, baclofen, gabapentine and pregabaline, but these do come with severe side effects.  
Oct 15 '19 · 0 comments
Product Name: PALMITOYLETHANOLAMIDE
Synonyms:PEA PALMIDROL;PALMITYLETHANOLAMIDE;PALMITOYLETHANOLAMIDE;Palmidrol
CAS:544-31-0
MF:C18H37NO2
MW:299.49
EINECS:208-867-9
Melting point:97-98ºC
Chemical Properties:white powder
Purity:99%
Package:1kg/25kg/foil bag
Uses:antiinflammatory.Anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties .Palmitoylethanolamide
Palmitoylethanolamide/PEA is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α). 
Palmitoylethanolamide / PEA powder 544-31-0 Application:

Palmitoylethanolamide/PEA has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties.
Oct 15 '19 · 0 comments
Chemical Name: 2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide ;2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-

methoxypyridin-3-yl)acetamide.Compound 7P powder

CAS No.: 1890208-58-8

Reaxys Registry Number: 29568294
Molecular Formula: C22H23N3O5S
Molecular Weight: 441.508
Assay:99%min
InChI Key: NAXWKPFXCOBXLE-UHFFFAOYSA-N

Density(Predicted): 1.329±0.06 g/cm3 |Condition:Temp:20 Press:760Torr

Function

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways.here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo.further optimization of compound 7p and elucidation of the

mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.
Oct 15 '19 · 0 comments
Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors.Nootropics Powder

Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD) drugs and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide.

Galantamine Hydrobromide Function:

1) anti-oxidation series:
bilberry extract, cranberry extract, grape seed extract, elderberry extract, lutein, zeaxanthin, pine bark extract, rosemary extract, pine bark extract. lemon balm extract.

2) liver protecting:
silybum marianum extract, artichoke extract, antrodia camphorate extract, schisandea extract.

3) immune system enhancer series:
wolfberry extract, echinacea extract, tribulus terrestris extract, resveratrol, 5htp, citrus aurantium extract, nettle extract, red cover extract, reishi extract, rhodiola rosea extract, 

black cohosh extract, astragalus extract, ginseng extract, cinnamomum cassia extract, schisandra chinensis extract.

4) heat-clearing and detoxifying series:
lemon balm extract, dandelion extract.

5)weight loss series:
white kidney bean extract, garcinia cambogia extract, cassia nomame extract, 5htp.

6)man and woman healthy:
yohimbe bark extract, common cnidium extract, epimedium extract, pygeum africanum extract, saw palmetto extract, soybean extract, pueraria lobata extract, wild yam extract.
7) mushroom extract:
reishi extract, maitake extract, shitake extract, cordceps extract.
8) anti-cancer:
resveratrol, wolfberry extract, flaxseed extract, pomegranate extract, bilberry extract.
9) anti-depressant:
passiflora incarnate extract, st john's wort extract.
Oct 15 '19 · 0 comments
Galanthamine Hydrobromide is a strong (reversible) cholinesterase inhibitor, increasing the susceptibility of the organism to acetylcholine, and treat for mild to moderate dementia of the Alzheimer's type.Galantamine Hydrobromide
Our galanthamine Hydrobromide is extracted from Lycoris radiata (L.Herit.) Herb, The production facility was inspected and classified as acceptable by U.S FDA in 2006,.To ensure the stable supply of Galanthamine HBr, a large area of herbs have been cultivated and advanced extract technology have been adopted for both enhancing the yield and purifying fine products.
Galanthamine is a kind of anticholinesterase drug, which can better improve the conduction between nerve and muscle. it could be used myasthenia gravis, progressive myodystrophy, post polio syndrome, child brain paralysis, sense obstruction, cinesipathy and polyneuritis induced by nervous system diseases.

Galantamine Hydrobromide Function:

1) anti-oxidation series:
bilberry extract, cranberry extract, grape seed extract, elderberry extract, lutein, zeaxanthin, pine bark extract, rosemary extract, pine bark extract. lemon balm extract.

2) liver protecting:
silybum marianum extract, artichoke extract, antrodia camphorate extract, schisandea extract.

3) immune system enhancer series:
wolfberry extract, echinacea extract, tribulus terrestris extract, resveratrol, 5htp, citrus aurantium extract, nettle extract, red cover extract, reishi extract, rhodiola rosea extract,

black cohosh extract, astragalus extract, ginseng extract, cinnamomum cassia extract, schisandra chinensis extract.

4) heat-clearing and detoxifying series:
lemon balm extract, dandelion extract.

5)weight loss series:
white kidney bean extract, garcinia cambogia extract, cassia nomame extract, 5htp.

6)man and woman healthy:
yohimbe bark extract, common cnidium extract, epimedium extract, pygeum africanum extract, saw palmetto extract, soybean extract, pueraria lobata extract, wild yam extract.

7) mushroom extract:
reishi extract, maitake extract, shitake extract, cordceps extract.

8) anti-cancer:
resveratrol, wolfberry extract, flaxseed extract, pomegranate extract, bilberry extract.

9) anti-depressant:
passiflora incarnate extract, st john's wort extract.

10) antibacterial:
white willow bark extract, citrus aurantium extract, pomegranate extract, senna extract, magnolia extract, ginger extract, scutellaria baicalensis extract, shikimic acid,echinacea

purpurea extract, chlorogenic acid.

Galantamine Hydrobromide Dosage Oral, one time 5mg, 4 times a day; three days later changed to a 10mg, 4 times a day or as directed. Epilepsy, hyperactivity, mechanical intestinal obstruction, bronchial asthma,

angina and bradycardia are hanged.Glaucoma patients should not be used.  
Oct 15 '19 · 0 comments
Nicotinamide Riboside (NR) is a recently discovered form of vitamin B3 that can increase levels of Nicotinamide Adenine Dinucleotide (NAD+) levels in humans.
NAD+ is a key co-enzyme that the mitochondria in every cell of our bodies depend on to fuel all basic functions.
4/">Nicotinamide Riboside Chloride powder

NAD+ levels drop as we age and when our bodies are stressed by disease or chronic inflammation.
Niacinamide is a component of coenzyme I and coenzyme II, becoming the coenzyme of many dehydrogenases.In food processing, nicotinamide is used together with Vc as a color

former
Niacin is also called vitamin B3, or vitamin PP, formula: C6H5NO2, heat resistant, can be sublimated. Niacin is also known as nicotinic acid and niacin. The human body also

includes its derivative nicotinamide or nicotinamide. It is one of the 13 vitamins necessary for human body, is a water-soluble vitamin, belongs to the B family of vitamin B. Nicotinic acid in converted into niacinamide, nicotinamide coenzyme and part of coenzyme , participates in the metabolism of lipids and tissue respiration of oxidation process and the

process of anaerobic decomposition sugar.
Bulk Nicotinamide Riboside Powder is a natural ingredient that is found in milk. It is actually related to niacin and other forms of vitamin B3.
This molecule has become more and more popular today because of various scientific studies that prove its ability to prevent obesity by helping you fight weight gain.

Researchers have found that this molecule can serve as a unique supplement that will boost one's metabolism to help burn off more calories and prevent weight gain.
Apart from preventing weight gain, it also helps boost muscle performance, increase energy expenditure, and minimize the risk factors of diabetes.

Function of Bulk Nicotinamide Riboside Powder
1.Bulk Nicotinamide Riboside Powder has the function of loosing weight;
2.Bulk Nicotinamide Riboside Powder can Increase energy;
3.Bulk Nicotinamide Riboside Powder can help to Lower cholesterol levels;
4.Bulk Nicotinamide Riboside Powder can treat metabolic disorders;
5.Bulk Nicotinamide Riboside Powder, lower risk factors of diabetes.
Oct 15 '19 · 0 comments
It displays neuroprotective properties with simultaneous advantages for mood, memory, and learning. The racetam 

family is one of the famous groups of nootropics. Even though it has similar structure, every racetam family have distinctive function and payback. As a fat-soluble medicine, 

Nefiracetam can easily overtake through the blood-brain barrier when compared to water-soluble pills such as piracetam. Because of this, the smaller dosage appears to be efficient. If you are affected by brain problems, consult your personal doctor and then take the Nefiracetam Powder for your treatment like Nootropics Powder.

History of Nefiracetam

It is a synthetic nootropic medicine derived from the original racetam, piracetam. Though Nefiracetam was obtained from piracetam, structurally it is more similar to Aniracetam. It is created in the 1990s, it is one of the latest racetam nootropics. In its short time on the market, it has experienced by animal studies and some human studies as well as clinical tests. Still, it is safe and methods of action are quite well implicit.

Mechanism of Action

This powder works in various different methods of action, some of them are closely aligned with other racetams and it may not be familiar with using aniracetam or piracetam. It has two mechanisms. The first method is by prolonging the opening of calcium channels. By taking this powder, you can raise alarms regardless of the synapses mainly leading to more brain stimulations and creating it more likely that anyone neuron receptor will be burnt out. The second mechanism of action connected with Nefiracetam involves the potentiation of nicotinic acetylcholine receptors. These actions have a number of various effects, including the release of GABA and glutamate that are two of the extra powerful 

neurotransmitters in the brain.

Benefits of Using Nefiracetam

It has enhancing intelligence brain health. This cytoprotective action is mediated by an improvement of GABAergic, cholinergic, and monoaminergic neuronal systems. It has shown to effectively treat apathy and enhance motivation in the post-stroke patient. It has been exposed to exhibit antiamnesia effects for the Alzheimer’s type and cerebrovascular type of dementia. Here are some advantages of using Nefiracetam drug.

It is one of the main Nefiracetam benefits is better memory and information maintenance in the longer term.
The clinical studies exposed that this supplement can lead to enhanced spatial learning ability.
The Nefiracetam Powder may also be helpful in treating patients with cognitive decline as well as enhancing the health and retention of your brain cells.
It has been found useful for reducing stress, anxiety, and depression.
Oct 15 '19 · 0 comments
What is Nefiracetam?
Nefiracetam is a nootropic antidementia drug of the racetam family.

Nefiracetam's cytoprotective actions are mediated by enhancement of GABAergic, cholinergic, and monoaminergic neuronal systems. It has been shown to effectively treat apathy

and improve motivation in post-stroke patients. It has been shown to exhibit antiamnesia effects for the Alzheimer's type and cerebrovascular type of dementia.In addition, it has

also been shown to have antiamnesia effects against a wide variety of memory impairing substances, including: ethanol, chlorodiazepoxide (Librium), scopolamine, bicuculline,

picrotoxin, and cycloheximide.
Nefiracetam is a nootropic drug of the racetam family. Preliminary research suggests that it may possess certain antidementia properties in rats.
Functions of Nefiracetam
Nefiracetam's cytoprotective actions are mediated by enhancement of GABAergic, cholinergic, and monoaminergic neuronal systems.[citation needed] Preliminary studies suggest

that it improve apathy and motivation in post-stroke patients. It may also exhibit antiamnesia effects for the Alzheimer's type and cerebrovascular type of dementia. In addition,

research in animal models suggests antiamnesic effects against a number of memory impairing substances, including: ethanol, chlorodiazepoxide, scopolamine, bicuculline,

picrotoxin, and cycloheximide.
Application of Nefiracetam
Application Nefiracetam (DM-9384) is a pyrrolidone nootropic agent being developed for the treatment of Alzheimer's type and poststroke vascular-type dementia. It has shown the ability to increase the FUNCTION AND APPLICATION

1. Memory. One of the primary Nefiracetam benefits is better memory and information retention in the long term.
2. Learning Ability. There have been studies showing that this supplement can lead to improvements in spatial learning abilities. Nefiracetam also has a much more potent effect

on increasing attention spans, concentration and focus as compared to other nootropics like Pramiracetam, Oxiracetam or Piracetam.
3. Healthy Brain Cells. It may also be helpful in treating patients with cognitive decline as well as improving the health and maintenance of your brain cells. Taking Nefiracetam is

thought to actually protect brain neurons from premature cell death due to cytoprotective actions.
4. Stress, Anxiety, Depression. Nefiracetam has been found useful for reducing stress, anxiety, and even depression. The mechanisms of action for these supplements are similar

in many respects, but Nefiracetam seems to exhibit a wider range of effects.
5. Seizures. Studies also indicate that this supplement might be effective in treating seizures. This includes both convulsive and non-convulsive seizures. The primary effect is to

greatly reduce the effects of amygdala based seizures and use for stroke patients in reducing the number and duration of post-stroke seizures.
6. Alzheimer's and Dementia. May have a therapeutic role in Alzheimer's and Dementia, but this has not been well investigated. Preliminary evidence seems promising
Oct 15 '19 · 0 comments
Alcoholism is a major problem in the United States. Alcohol abuse costs almost $220 billion to the U.S. economy every year. That’s a shocking number. We need a better

treatment right now,” said study lead author Phani Babu Tiruveedhula from the University of Wisconsin, Milwaukee.
3/">beta carboline powder


The exact causes of alcoholism are not well understood, but scientists explain that the urge to drink is related to the brain’s pleasure centers. They have found that alcohol

triggers the brain to release dopamine, the same neurochemical whose levels increase in response to pleasurable behavior.

Some drugs currently available to treat alcoholism are aimed at dopamine.“They dampen out the dopamine system a little bit, so you don’t get so happy when you have an

alcoholic beverage,” said co-author Dr James Cook, also from the University of Wisconsin, Milwaukee.

“But these medications, derived from a class of compounds called opioid antagonists, cause depression in some patients. And they’re addictive themselves, which can lead to

drug abuse. Valium is an example of another common drug used to treat alcoholism that is also addictive.”

Looking for an alternative, Tiruveedhula and co-authors focused on beta-carboline compounds known to cause some of the same results as Valium and the opioid antagonists

without the unwanted side effects.

In tests using rats bred to crave alcohol, they found that administering these compounds drastically diminished the rats’ drinking.What’s more, they observed very few of the side

effects common to alcoholism treatment drugs, such as depression and losing the ability to experience pleasure.

The drugs appeared to reduce anxiety in alcoholic rats, but not in control animals.Because this is different from what is seen with current drugs, the scientists think the result hints

that the new compounds work much differently than opioid antagonists. As such, the beta-carbolines may also be less addictive.

“What excites me is the compounds are orally active, and they don’t cause depression like some drugs do,” Dr Cook said.“If everything works out, a drug could be ready for the

market in 5 – 6 years,” he added.  
Oct 15 '19 · 0 comments
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