freemexy's blog
The China International Import Expo is “much more than a trading
market but a place to call for broader cooperation across the world,”
according to Jin Liqun, president of the Asian Infrastructure Investment
Bank.The second China International Import Expo will be held at the
National Exhibition and Convention Center in Shanghai from November 5 to
10, 2019.For further information about China International Import Expo,
please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie shanghai， you can visit shine news official website.
“The CIIE is of significant importance to share the values of openness, innovation and communication,” Jin said in an interview after he spoke at the Hongqiao International Economic Forum.Jin said the multilateral development bank dedicated to funding infrastructure construction around the world has a mission similar to the CIIE.
“We expect to become an open platform where all members can share their experience in development,” Jin said. “Only through communication can people become innovative, and only through sharing can countries grow stronger.”
The bank had made great progress since it went into operation in 2016, he said. Starting from 57 member countries and regions, it now had 100 members and would continue to expand next year, Jin said.
The bank had established a fundamental operating system and nurtured its own enterprise culture, he said. With a stringent enterprise structure, it is using most of its resources in expanding loans, and it had obtained the status of United Nations Permanent Observer.
“We mainly focus on projects in transport, energy, urban construction and water management that closely connect with environmental, social and governance issues that support sustainable growth,” Jin said.
Chan Chun Sing, Singapore’s trade and industry minister, highlighted
the importance of connectivity and how it needs to go beyond hardware to
include finance and technology when he spoke at Wednesday’s
Singapore-China Trade and Investment Forum. The second China
International Import Expo will be held at the National Exhibition and
Convention Center in Shanghai from November 5 to 10, 2019.For further
information about China International Import Expo, please visit: https://www.shine.cn/China-International-Import-Expo/ or
https://www.shine.cn/ciie2019/v1.To get more ciie shanghai, you can visit shine news official website.
Chan also noted that the collaboration between Singapore and China had developed in tandem with China’s integration into the global economy."We've seen a lot more foreign faces at the CIIE this year than the first session, which indicates greater interest in foreign businesses in the expo and the Chinese market," Chan said.
At the forum, three memorandums of understanding were signed to boost collaboration between Singaporean and Chinese enterprises in finance, biotechnology and shipping.Led by the Singapore Business Federation, a delegation of 84 prominent Singaporean companies are participating in this year’s China International Import Expo.
Spanning logistics and transportation, finance and banking, education, health care, food and beverages and high technology sectors, the delegation is showcasing a wider range of innovative, high-quality and reliable products and services this year.
"Singapore’s strong presence and vibrant showcase at this year’s CIIE demonstrates the strengths and value propositions of Singapore and our businesses across diverse sectors," said federation chairman S.S. Teo.
"Besides showcasing Singapore’s quality products and services to China and the world, we also hope to promote greater collaboration between Singaporean and Chinese companies in third-party markets in areas of regional connectivity, finance as well as legal cooperation. We hope to see more MOUs signed and deals made in the days to come," Teo said.
Ho Meng Kit, the federation’s CEO, added: "China has been and continues to be a key market for many of our companies. The growing wealth of Chinese consumers and the rapid development of e-commerce are driving the rise of China’s consumer market. And as Chinese consumers become more discerning, the demand for high-end and quality products is also growing and this spells significant opportunities for our companies."
The forum, hosted by the federation and the Singapore branch of the Bank of China,was attended by nearly 300 representatives of Chinese and Singaporean enterprises. During the first CIIE, the bank served as a bridge for eight pairs of Singaporean and Chinese enterprises which signed 12 MOUs with the total value exceeding 700 million yuan (US$100 million).The federation launched a WeChat program on October 31 to help buyers connect easily with Singaporean exhibitors, allowing them to send messages and make appointments.
However, many people wonder whether it’s effective.This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.wisepoqder Alpha-lipoic Acid
What is alpha-lipoic acid?
Alpha-lipoic acid is an organic compound found in all human cells.It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).What’s more, it has powerful antioxidant properties.
Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.
The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.
Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).
Alpha-lipoic acid and weight loss
Research has shown that alpha-lipoic acid may affect weight loss in several ways.Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).
When AMPK is more active, it may increase feelings of hunger.On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).
However, human studies show that alpha-lipoic acid only slightly impacts weight loss.An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.
Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.
Alpha-lipoic acid or ALA is a naturally occurring compound that's made in the body. It serves vital functions at the cellular level, such as energy production. As long as you're healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.wisepoqder Alpha-lipoic Acid powder
Research on the effects of ALA supplementation is sparse. What there
is, though, does suggest some possible benefits. Here is what's known
about the potential health benefits of using alpha-lipoic acid
supplements.
ALA is an antioxidant. Antioxidants protect against damage to the body's cells.
There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body.Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive.
Studies show that about 30% to 40% of the oral dose of an ALA supplement is absorbed. ALA may be better absorbed if it is taken on an empty stomach.
While studies are still sparse, there is some evidence that ALA may have at least two positive benefits for individuals with type 2 diabetes. A few studies have suggested that alpha-lipoic acid supplements may enhance the body's ability to use its own insulin to lower blood sugar in people with type 2 diabetes. ALA may help reduce the symptoms of peripheral neuropathy -- nerve damage that can be caused by diabetes.
In Europe, ALA has been used for years to provide relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy. In particular, one large study strongly suggested that large intravenous doses of ALA were effective at relieving symptoms. But the evidence for oral doses is not as strong. More research is needed to establish the effectiveness of oral ALA supplements for diabetic neuropathy.
L-arginine, an amino acid, is found in foods like dairy products and meats. It helps in bodybuilding, muscle development, and improved performance.
These benefits have been researched with most conclusions being made after extensive studies.One study showed that L-arginine improves DNA synthesis and mitochondrial bioenergetics, which may also be responsible for the beneficial effects of Arg on intestinal mucosal cells.wisepoqder L(+)-Arginine
L-arginine is produced by the body in adequate amounts to elevate the action of a nitric acid in the body. It also has biochemical components that enhance the metabolism of fats.It is mostly given to people dealing with obesity to help burn the fat and enhance the formation of muscle mass. Supplementing with l-arginine allows your body to use accumulated fats as a source of energy.
The accumulated fat is burnt to produce energy and to aid in muscle mass formation and development. L-arginine thus boosts your body metabolism as well as forms building blocks for muscle formation.As a result, you lose fat mass but retain your muscle mass.
To test the efficacy of l-arginine on weight loss, a research study was conducted. L-arginine supplements were given to obese males who had type 2 diabetes to see if it would help in weight loss.
The study had more than 300 subjects who were subjected to the l-arginine and placebo groups.They consumed 1000kcal per day and exercised 90 minutes every day for five days in a week. They also took 8.3g of l-arginine per day.
The results from the 21-day study showed that l-arginine increases weight loss. People who got l-arginine showed that 100 percent of the weight loss was all fat compared to those on placebo who lost up to 40 percent muscle mass.
Larger doses of l-arginine for weight loss allow for faster fat burning, which is needed in the development of a leaner body:
The upper recommended l-arginine amount per serving is 5 to 10 grams.
You should start with a lower serving and increase the dosage as you
continue to use the supplement. It stimulates more body fat burning and
formation of muscle, thus making it ideal for people looking to lose
weight.
This supplement is highly effective in the treatment of obesity. However, excessive use can lead to harmful side effects.Amino acids are known to aid in bodybuilding. For instance, l-arginine minimizes the action of the adipose tissue, which is the belly fat. Obesity is mainly characterized by stores of belly fat. The more a person accumulates the belly fat, the higher the risk of developing cardiovascular diseases.
Stimulates production of HGH
L-arginine also increases the levels
of HGH (Human Growth Hormone) that supports increased metabolism.
However, it increases HGH levels when taken in very large amounts.
Taking large amounts of the supplement is not advisable, however,
because it can cause side effects such as stomach cramps and diarrhea.
Increased energy:
Additionally, l-arginine is an ingredient long
used in supplement formulas. It has been used for a wide range of
functions including the enhancement of sports performance and boosting
cardiovascular health. Since it is a nitrogenous acid, it stimulates the
production of a nitric oxide whose making function is to dilate the
blood vessels. Increased blood flow through the body increases energy
and enhances the overall body performance.
Dilated vessels ease the
work of the heart, thus improving your cardiovascular health by lowering
your blood pressure. They also transport blood faster to different
pressure points, which increases your energy for workouts.
Besides increasing your energy, dilated blood vessels also act as a treatment basis for erectile dysfunction.Some studies have pointed out that it increases semen production, implying that could boost sexual performance. It prevents renal dysfunction in patients with type- 2 diabetes.
BioVision's L-Arginine Assay Kit provides a quick, specific, and easy method for the measurement of total L-arginine concentrations in a wide variety of samples. In this enzyme-based assay, L-arginine is converted into a series of intermediates, which will further react with a probe producing a stable colorimetric signal (OD: 450 nm). The kit is simple to use, sensitive and high-throughput adaptable and can detect as low as 1 nmol/well of L-arginine in biological samples.
There are plenty of powerful new drugs to help prevent and treat chronic health problems. But we also know that certain nutrients may help, as well. Take arginine, for example. Arginine has gotten lots of attention lately for its potential heart benefits. That's important because, today, about 85.6 million Americans have some form of cardiovascular disease.wisepoqder Antiaging Powder
Deficiencies of arginine are rare. It's abundant in many different types of foods, and your body can also make it. Arginine-rich foods include red meat, fish, poultry, wheat germ, grains, nuts and seeds, and dairy products. But what does arginine do for the heart, and are there potential side effects?As a natural dietary supplement, arginine has garnered particular attention for its possible heart benefits.
What Are Arginine's Heart Benefits?
In the body, the amino acid
arginine changes into nitric oxide (NO). Nitric oxide is a powerful
neurotransmitter that helps blood vessels relax and also improves
circulation.
Some evidence shows that arginine may help improve blood flow in the arteries of the heart. That may improve symptoms of clogged arteries, chest pain or angina, and coronary artery disease. However, there currently is no data on how the long-term use of arginine affects cholesterol or heart health.Since arginine may help arteries relax and improve blood flow, it may also help with erectile dysfunction.
There are other potential health benefits with arginine, such as possible reduction of blood pressure in some people and improved walking distance in patients with intermittent leg cramping and weakness known as intermittent claudication. However, the scientific studies are not conclusive enough for experts to make any firm recommendations.
Not all studies on arginine have been positive. A 2006 study showed that arginine was not helpful -- and may have been harmful -- for treating heart attacks in combination with standard treatment.
Senolytics target cellular senescence, a process in which damaged cells, rather than dying, persist and become toxic to cells around them. Cellular senescence has been shown to drive multiple age-related diseases, including idiopathic pulmonary fibrosis (IPF), a chronic, irreversible and progressive disease that results in scarring of the lungs. In animal studies, run by Mayo Clinic collaborators James Kirkland, M.D., Ph.D.; Nathan LeBrasseur, Ph.D., M.S., and Tamara Tchkonia, Ph.D., senolytics selectively cleared these toxic cells in mice that model IPF.wisepoqder Quercetin
A lethal disease for which there are few options
"IPF is a devastating and progressive fibrotic lung disease with a median survival of less than five years in newly diagnosed adults usually over 60 years of age," said Anoop M. Nambiar, M.D., M.S., associate professor of medicine at UT Health San Antonio and founding director of the university's Interstitial Lung Disease Program, one of 60 Pulmonary Fibrosis Foundation Care Centers in the United States. Dr. Nambiar is co-first author of the research manuscript and enrolled 12 of the patients at UT Health San Antonio and the South Texas Veterans Health Care System.
Despite the current availability of two U.S. Food and Drug Administration-approved therapies that may slow down disease progression in some IPF patients, the prognosis remains poor and is worse than for many common cancers, Dr. Nambiar said. Lung transplantation may be lifesaving, but often is only an option for younger, healthier patients. "There remains a significant unmet need for safer and better treatments for patients with IPF," Dr. Nambiar said.
Patients enrolled in Texas, North Carolina
In this first-in-human pilot study, the investigators enrolled 14 older adults diagnosed with stable, primarily mild-to-moderate IPF. Participants were enrolled at both UT Health San Antonio, which served as the pr
Researchers have demonstrated that nanoparticles coated with quercetin molecules can selectively target and eliminate harmful senescent cells.
As you age, increasing numbers of your cells enter into a state known
as senescence. Senescent cells do not divide or support the tissues of
which they are part; instead, they emit a range of potentially harmful
chemical signals that encourage nearby healthy cells to enter the same
senescent state. Their presence causes many problems: they reduce tissue
repair, increase chronic inflammation, and can even eventually raise
the risk of cancer and other age-related diseases.wisepoqder Quercetin powder
Senescent cells normally destroy themselves via a programmed process
called apoptosis, and they are also removed by the immune system;
however, the immune system weakens with age, and increasing numbers of
senescent cells escape this process and begin to accumulate in all the
tissues of the body.
By the time people reach old age, significant numbers of these senescent cells have built up, causing chronic inflammation and damage to surrounding cells and tissue. These senescent cells are a key process in the progression of aging.
Senescent cells only make up a small number of total cells in the body, but they secrete pro-inflammatory cytokines, chemokines, and extracellular matrix proteases, which, together, form the senescence-associated secretory phenotype, or SASP. The SASP is thought to significantly contribute to aging and cancer; thus, targeting senescent cells and removing them has been suggested as a potential solution to this problem.
The trouble with quercetin
Quercetin is a naturally occurring plant polyphenol, a category that often has poor water solubility, chemical instability, or poor bioavailability. These confounding factors could be muddling its effectiveness and making it unreliable as a senolytic therapy. This likely explains why different senolytic studies using quercetin have yielded conflicting results: there are simply too many processes that can influence these natural molecules for them to be reliable.
We have seen in past mouse studies and recent Mayo Clinic human trials that quercetin, when used in combination with the cancer drug dasatinib, can be the basis for an effective therapy for eliminating senescent cells. Unfortunately, on its own, quercetin does not have a significant senolytic effect, which is possibly due to its limitations as a polyphenol.
However, there are ways to overcome these issues with quercetin and other similar polyphenols, and that is by using special delivery systems that make the molecules more effective and controllable. Polymer nanoparticles, lipid-based carriers, inclusion complexes, micelles, and conjugate-based delivery systems are all examples of approaches that can deliver molecules more effectively.
Nanoparticles make quercetin more effective
The researchers of this study opted to use a nanoparticle-based delivery system to carry quercetin molecules to senescent cells in order to destroy them [1]. They created magnetite nanoparticles and coated their surface with quercetin molecules, then examined the senolytic action of this approach.
They found that the nanoparticles were effective at attenuating inflammator
NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12-month-long NMN administration to regular chow-fed wild-type C57BL/6N mice during their normal aging. Orally administered NMN was quickly utilized to synthesize NAD+ in tissues. Remarkably, NMN effectively mitigates age-associated physiological decline in mice. Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies. Consistent with these phenotypes, NMN prevented age-associated gene expression changes in key metabolic organs and enhanced mitochondrial oxidative metabolism and mitonuclear protein imbalance in skeletal muscle. These effects of NMN highlight the preventive and therapeutic potential of NAD+ intermediates as effective anti-aging interventions in humans.wisepoqder beta-Nicotinamide mononucleotide powder
Historically unprecedented worldwide trends in population aging are predicted to become an incessant burden on governmental healthcare finances (OECD, 2013). To make the process of aging healthy and prevent expensive age-associated health problems, efforts to develop effective, affordable, anti-aging interventions have recently been intensified, leading to some promising compounds, such as metformin, rapamycin, and SIRT1 activators (Barzilai et al., 2016, Hubbard and Sinclair, 2014, Lamming et al., 2013). Whereas these compounds were originally developed as pharmaceutical drugs, some endogenous compounds might also have the potential to achieve healthy and productive lives even at a very old age (Imai, 2010, Imai and Guarente, 2014).
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), key NAD+ intermediates in mammals, could be such candidates (Imai, 2010). NMN is synthesized from nicotinamide (Nic), an amide form of vitamin B3, and 5′-phosphoribosyl-pyrophosphate (PRPP) by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this particular NAD+ biosynthetic pathway (Cantó et al., 2015, Imai and Guarente, 2014). NR is phosphorylated to NMN by nicotinamide riboside kinases (NRKs) (Belenky et al., 2007). Once NMN is synthesized, it is converted to NAD+ by three NMN adenylyltransferases, NMNAT1-3. The short-term administration of either NMN or NR has been reported to have remarkable therapeutic effects on metabolic complications and other disease conditions. For example, we have shown that NMN ameliorates impairments in glucose-stimulated insulin secretion in aged wild-type mice and some genetic mouse models (Ramsey et al., 2008, Revollo et al., 2007). NMN treatment also significantly improves both insulin action and secretion in diet- and age-induced type 2 diabetic or obese mouse models (Caton et al., 2011, Yoshino et al., 2011). Furthermore, NMN protects the heart from ischemia/reperfusion injury by preventing NAD+ decrease induced by ischemia (Yamamoto et al., 2014), maintains the neural stem/progenitor cell population, and restores skeletal muscle mitochondrial function and arterial function in aged mice (de Picciotto et al., 2016, Gomes et al., 2013, Stein and Imai, 2014), ameliorates mitochondrial function, neural death, and cognitive function in Alzheimer’s disease rodent models (Long et al., 2015, Wang et al., 2016). NR is also able to ameliorate mitochondrial dysfunction in obese mouse models (Cantó et al., 2012, Gariani et al., 2015, Lee et al., 2015) and various mitochondrial disease models (Cerutti et al., 2014, Khan et al., 2014), attenuate cognitive deterioration in Alzheimer’s disease model mice (Gong et al., 2013), prevent DNA damage and hepatocellular carcinoma formation (Tummala et al., 2014), improve noise-induced hearing loss (Brown et al., 2014), and maintain muscle stem cell function (Zhang et al., 2016). Collectively, these findings strongly suggest that enhancing NAD+ biosynthesis by administering NMN or NR is an efficient therapeutic intervention against many disease conditions (Imai and Guarente, 2014).
Interestingly, it has been demonstrated that enhancing NAD+ biosynthesis extends lifespan in yeast, worms, and flies (Anderson et al., 2002, Balan et al., 2008, Mouchiroud et al., 2013). In rodents and humans, a number of studies have reported that NAD+ content declines with age in multiple organs, such as pancreas, adipose tissue, skeletal muscle, liver, skin, and brain (Gomes et al., 2013, Massudi et al., 2012, Mouchiroud et al., 2013, Stein and Imai, 2014, Yoshino et al., 2011, Zhu et al., 2015). Thus, enhancing NAD+ biosynthesis with NMN or NR is expected to provide significant preventive effects on various pathophysiological changes in the natural process of aging. To address this critical question, long-term administration studies need to be performed under normal conditions in wild-type mice.
To examine whether long-term administration of NMN shows preventive effects on age-associated pathophysiological changes, we treated regular chow-fed wild-type mice for 12 months with two different doses of NMN in their drinking water. We assessed a variety of functional traits, as well as long-term safety and toxicity, and found that NMN is remarkably capable of ameliorating age-associated physiological decline in mice. Our findings from this long-term administration study provide a proof of concept to develop NMN as an effective anti-aging compound that prevents age-associated physiological decline, hoping to translate the results to humans.