Raw Tadalafil (Cialis) powder (171596-29-5) Description

Cialis powder, sold under the brand name Cialis powder among others, is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension. It is a tablet taken by mouth. Onset is typically within half an hour and the duration is up to 36 hours.

Tadalafil powder, also known as IC351, is PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis powder, and under the name Adcirca for the treatment of pulmonary arterial hypertension.

Penile erection occurs when the penis fills with blood. This happens because the blood vessels that bring blood flow to the penis dilate, increasing the blood supply. At the same time, the blood vessels that remove blood from the penis contract. The blood accumulates in the penis, causing an erection.

When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP, which controls the dilation and contraction of the blood vessels that carry blood to and from the penis.

Another substance, PDE5, destroys cGMP. When this occurs, the blood vessels return to their normal size, and the erection ends. Tadalafil powder stops PDE5 from destroying cGMP. This causes the erection to last for longer.

The muscles of the arteries in the walls of the lungs also contain PDE5, which is why the same drug can also help with pulmonary hypertension treatment.

Quick Details
ProName: Cialis powder / Cialis Male Sex Enhance Po.
CasNo: 171596-29-5
Molecular Formula: C22H19N3O4
Appearance: White powder
Application: medical intermediate
DeliveryTime: within a week
PackAge: A variety of packing ways for your cho.
Port: Wuhan / Shanghai / Guangzhou ...
ProductionCapacity: 200 Kilogram/Month
Purity: 99.5%min
Storage: Kept in a well-closed, light-resistant.
Transportation: EMS, HKEMS, DHL, TNT, UPS, Fedex.
LimitNum: 10 Gram
Moisture Content: 0%
Impurity: 0.05%
Water content: 0%
Product Description
Nitrates drugs - clinical pharmacology studies have shown that Tadalafil Tablets can enhance the antihypertensive effect of nitrates drugs, so people who are taking any form of organic nitrate drugs are strictly prohibited from taking Tadalafil Tablets. For patients taking Tadalafil Tablets, nitrate drugs are considered only in the treatment of life - threatening conditions, or at least 48 hours after the last dose of Tadalafil Tablets should be considered. Even in this case, nitrate drugs can be given only under strict medical monitoring and appropriate hemodynamic tests (see "taboo", "usage" and "pharmacological toxicology").

Alpha blockers - when PDE5 inhibitors are combined with alpha blockers, should be cautious. PDE5 inhibitors, including Tadalafil Tablets and alpha adrenergic receptor blockers, are vasodilator agents that reduce blood pressure. When vasodilator is used together, it may have a superposition effect on blood pressure. The clinical pharmacology of dalazine combined with doxazosin or tamoxine was studied (see "notice", "usage" and "pharmacological toxicology").

An antihypertensive drug, PDE5 inhibitor, including TEDA, is a mild systemic vasodilator. To assess the effect of diaralan on antihypertensive effects of specific antihypertensive drugs (amiodarone, angiotensin II receptor blocker, benzyl fluorothiazide, enalapril and metoprolol), clinical pharmacology was conducted. After being combined with these drugs, blood pressure was slightly lower than placebo (see "precautions" and "pharmacology and toxicology")

The stability of an extemporaneously prepared tadalafil oral suspension was studied. An oral suspension of tadalafil 5 mg/mL was prepared by thoroughly grinding 15 20-mg Cialis powder in a glass mortar. Thirty milliliters of Ora-Plus and 30 mL of Ora-Sweet were mixed and added to the powder to make a final volume of 60 mL. Three identical samples of the formulation were prepared and placed in 2-oz amber plastic bottles with child-resistant caps and stored at room temperature (23-25 °C). A 1-mL sample was withdrawn from each of the three bottles with a micropipette immediately after preparation and at 7, 14, 28, 57, and 91 days. After double dilution (1:10 and 0.1:5 v/v) to an expected concentration of 10 μg/mL with methanol and mobile phase, respectively, the samples were assayed in duplicate using stability-indicating high-performance liquid chromatography. The samples were visually examined for any color change and evaluated for pH changes on each day of analysis. Taste evaluation was performed at the beginning and end of the study. Stability was defined as the retention of at least 90% of the initial concentration. At least 99% of the initial tadalafil concentration remained throughout the 91-day study period. There were no detectable changes in color, odor, taste, and pH, and no visible microbial growth was observed in any sample. An extemporaneously prepared suspension of tadalafil 5 mg/mL in a 1:1 mixture of Ora-Plus and Ora-Sweet was stable for at least 91 days when stored in amber plastic bottles at room temperature.

A generic version of Cialis® (Eli Lilly) tadalafil tablets (2.5 mg, 5 mg, 10 mg, 20 mg) for the United States market has been annouced by Teva Pharmaceuticals, in a first-to-file launch.

Tadalafil powder are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), and both ED and the signs and symptoms of BPH (ED/BPH). Tadalafil tablets are recommended for use up to 26 weeks when combined with finasteride to initiate BPH treatment.

“We’re proud to offer an affordable treatment option for the estimated 30 million men affected by ED, many of whom will also have symptomatic BPH which is estimated to affect 15 million men in the United States,” said Hafrun Fridriksdottir, EVP and Head of Global R&D for Teva, in a prepared statement.

The most common adverse reactions reported in clinical trials (≥ 2%) for tadalafil were headache, flushing, dyspepsia, nasal congestion, back pain, myalgia, pain in limb, naspharyngitis, upper respiratory tract infection, cough, diarrhea, urinary tract infection, gastroesophageal reflux disease, abdominal pain, gastroenteritis, and hypertension.

Tadalafil tablets are contraindicated in patients using any form of organic nitrate; and in patients with a known serious hypersensitivity to tadalafil. Furthermore, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.

Brendan O’Grady, EVP and Head of North America Commercial at Teva, noted that the launch of the generic tadalafil tablets builds on the company’s exclusive launch of a generic version of Viagra® (sildenafil) tablets last year. “We’re committed to ensuring that patients are able to access this medicine,” O’Grady said, in a prepared statement.

Adamis Pharmaceuticals Corporation (NASDAQ: ADMP) today announced that it has received a Refusal to File letter from the United States Food and Drug Administration (FDA) regarding its New Drug Application (NDA) for its sublingual Tadalafil powder product. As previously announced, on December 28th, 2018, Adamis submitted an NDA for fast-disintegrating sublingual tadalafil (APC-8000) with the FDA for the treatment of erectile dysfunction (ED).

Upon its preliminary review, the FDA determined that the submitted NDA was not sufficiently complete to permit a substantive review. The FDA requested that Adamis supplement and include in a resubmitted NDA (i) longer real-time (versus accelerated) stability data and (ii) additional dissolution data for both the clinical and registration batches. Adamis may seek immediate guidance from the FDA, including requesting a Type A meeting, to discuss the letter with the agency and seek additional guidance concerning information, data and specific deliverables that the agency would require for a resubmitted NDA to be deemed complete.

Dr. Dennis J. Carlo, President and CEO of Adamis, stated, “We are obviously very disappointed with this development and are evaluating the letter and what the FDA has requested. We intend to work closely with the FDA to try to clearly map the path forward.”

Tadalafil is a drug used for treating erectile dysfunction (ED), pulmonary hypertension and benign prostatic hyperplasia (BPH). Tadalafil is in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors which includes, among others, sildenafil and vardenafil. Tadalafil is the drug in Lilly’s Cialis®, sildenafil is the drug in Viagra® (Pfizer) and vardenafil is the drug in Levitra® (GlaxoSmithKline). All three drugs of these oral tablets are FDA approved and clinically indicated for the treatment of ED.

How does Laxogenin Work?

56786-63-1, also known as Laxogenin, is a plant compound and the best member of Brassinosteroids. Brassinosteroids is a class of polyhydroxysteroids that are seen as sixth class potent hormones, examples are Mustard, Castasterone etc. Brassinosteroids generally increases protein. Structurally, Laxogenin looks like the plant extract ecdysterone and functions as anabolic steroids but Laxogenin is natural and commonly considered to be free of liver-toxic side effects.

Although the process of effect has not been clarified, it however directly increases protein synthesis and reduces protein breakdown. Laxogenin is also believed to enhance muscle recovery and growth by inhibiting the stress hormone cortisol. When consumed in excess, cortisol levels can make it almost impossible to gain muscle or energy. Laxogenin does not perform the function of a prohormone by interfering with the body’s internal secretion of the endocrine glands. Laxogenin neither increases nor decreases endogenous levels of testosterone.

Laxogenin is a naturally-occurring, plant-derived substance, not a synthetic steroid concocted in some pharmaceutical laboratory. On top of that, there has been a substantial lack of research surrounding the actual mechanism behind Laxogenin's mechanism of action.

In other words, scientists still don’t know exactly how Laxogenin does what it does. But, according to the initial studies conducted in Russia, it is significantly increase muscle protein synthesis. Laxogenin has also been found to substantially reduce protein breakdown.

Additionally, some other info about the effects/actions of Laxogenin can be gleaned from the patent application for the ingredient. Specifically, the patent application states that Laxogenin can exhibit adaptogenic traits, helping your body "normalize" its stress response.

Platinum Lab has formulated a natural occurring sapogenin that assists with putting your body through an anabolic state through a non-hormonal pathway by assisting to enhance protein synthesis. This process aids with rapid muscle gains, muscle growth and strength. Not only does this supplement assist with muscle growth, but it also helps with increasing the rate of muscle recovery and balance cortisol response. Cortisol plays a large role in muscle and training recovery and assists in reducing the risk of muscle fatigue.
Since 5a-Hydroxy 56786-63-1 will not affect the hormone levels, restricting 5a-Hydroxy Laxogenin use is no longer needed. Often people use 5a-Hydroxy Laxogenin supplements for up to 4 months, regardless of what the goal is, whether it is to increase performance, build muscles, or reduce body fat.
Common Dosing of 5a-Hydroxy Laxogenin

The typical dose for 5a-Hydroxy Laxogenin is 50 to 100 milligrams per day. This can be cycled up to 12 weeks. It is suggested to have a 4-week break following each cycle to allow the receptors to be up-regulated for greater efficiency.
Use In Supplements

The advantages of 5a-Hydroxy Laxogenin are not as robust compared to anabolic steroids; however, they come with a number of benefits. 5a-Hydroxy Laxogenin is not detected on drugs screen; therefore, athletes who are tested need not be concerned about being caught for using this compound. Moreover, 5a-Hydroxy Laxogenin has no impact on the hypothalamus-pituitary-testicular-axis or estrogen levels; thus, there is no need to conduct a post cycle therapy or utilize an aromatase inhibitor. Anabolic steroids suppress luteinizing hormone and necessitate a robust post cycle therapy for effective recovery outcomes. 5a-Hydroxy Laxogenin can prevent fat gain and increase protein synthesis. It does not strain the liver.

Laxogenin 100a?? body building supplement is the product every athlete or health conscious person has been waiting for! Anyone who wants to build muscle and/or enhance athletic performance and currently is using legal prohormones, growth hormone releasers, and/or creatine supplements needs to pay attention. Laxogenin is the perfect synergistic product to use alongside any growth-related supplement. If you are ready to literally take supplementation to never seen before levels, Laxogenin is it. What is even more interesting is that compared to other testosterone or prohormone products on the market, this is safe for both men and women to take.56786-63-1
5a-Hydroxy Laxogenin is an ingredient Hi-Tech perfected via our synthesis process better than anyone in the industry, given our 23-year history with this ingredient. Hi-Tech's founder used every 5a-Hydroxy Laxogenin going back to the original Mesobolin, put out by Amino Discounters in the early 1990's. For men, Hi-Tech recommends using this product with IGF-1 products like our Pro IGF-1 to assist in lean mass gains. For females Laxogenin 100a?? can be taken by itself and not cause androgenic side effects. Laxogenin 100a?? contains 100mg which isA 2-4 times stronger than its competitors at the same price range. It is also manufactured with Hi-Tech's proprietary Cyclosomea?? technology (described below). A Laxogenin 100a?? is perfect for:

5a-hydroxy-laxogenin is a steroidal sapinogen, although whether or not it is the desired laxinogen is a mystery since no lab standard for it is available, nor was it referenced within the GCMS library.RAW 5A-HYDROXY LAXOGENIN POWDER
Marketing claims for this compound say it is the only product ever designed to increase mass and strength without steroidal influence and that it doesn't test positive for steroids.
Athletes have found dramatic strength increases in 3-5 days, and muscle mass increases in 3-4 weeks. Muscle mass or fat loss is only a function of caloric intake. If you are a male that is a hard gainer or someone that is looking to put on extra lean muscle and most important, keep it. This is the ONLY product EVER designed to do this without steroidal influence. Product is great for drug testing and does not test positive for steroids. Tests showed that protein synthesis increased by over 200% , the key to lean muscle growth and accelerated repair. Body fat reduction is one of the key components of this molecule. When you restrict your calories you reduce body fat dramatically. In testing the molecule has balance cortisol response which is the major cornerstone to healthy recovery and reduction of muscle wasting. It's also been shown to balance cortisol on calorie restricted diets, helps control glucose and increases thyroid function.

5-Alpha-Hydroxy-Laxogenin, also known as Laxogenin is derived from a plant called Smilax Sieboldii.Yes, that is right – 5a-hydroxy laxogenin is a completely natural product.The plant is found near forests and grassy slopes near sea levels in Japan and China. What makes this plant so special is the fact that it contains steroidal saponins.RAW 5A-HYDROXY LAXOGENIN POWDER

This product belongs to the Brassinosteroids, which is basically a group that is classified as plant hormones. Small amounts are found in leaves and seeds. You can even find high amounts in mustard.

Once researchers started looking at this compound more carefully, they found out that it was rather unique.Now, this should give you a pretty good idea why 5a-hydroxy laxogenin is often referred to as the plant steroid.

You are probably asking yourself, if it is considered a steroid, it must have pretty bad side effects?

Nope! It is a natural product and there are minimal side effects when using it. It does not mess around with your hormones and it works completely different than steroids. You will not have to worry about experiencing horrendous side effects.Let’s talk about what this product has to offer. 5a-hydroxy laxogenin is known for its muscle-building properties. This is the main reason why it has gotten so popular in the supplement industry.

5a-hydroxy Laxogenin increases protein synthesis and reduces protein breakdown, which is pretty crazy if you think about it. This compound is made out of natural ingredients AND has the ability to impact such an important biological process.