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Aniracetam (chemical name 1-[(4-methoxybenzoyl)]- 2-pyrrolidinone) is purported to be much more potent that piracetam so you need to take significantly less of it to achieve a similar effect. Unlike piracetam, aniracetam is fat soluable and therefore should be taken with a meal.Aniracetam
Nootropics, also known as smart drugs, are a group of health supplements which are purported to increase cognitive ability, intelligence, memory, and general brain function.
Aniracetam is an ampakine and nootropic of the Racetam family. This supplement is used for and improving reaction time and mental focus.
As an analogue to piracetam, it is considered that aniracetam is virtually non-toxic, non addictive, has very few side effects, and enhances verbal memory. Nonetheless, unlike piracetam there have been fewer clinical trials and research into the affects of aniracetam, however it is widely considered to be considerably more potent than piracetam, and users of aniracetam generally report that it increases alertless, cognitive ability, attention span, and learning ability.
It is suggested that aniracetam affects the Corpus Callosum in the same way as piracetam, which is the part of the brain which connects the left (logical) and right (creative) hemispheres of the brain. It is suggested that by increasing the linkages between the left and right hemispheres of the brain, piracetam users benefit from greater cognitive potential.
Aniracetam has also been shown to have a more potent affect on the AMPA receptor than piracetam, which results in enhanced focus and concentration.
As with all of our racetams, racetam is very popular among students, sufferers of Alzheimer's and dementia, those recovering from alcoholism, and life extension enthusiasts.
As with most all racetams, aniracetam should be taken with a choline source such as choline bitartrate. It is also often ‘stacked’ with other racetams as well as with supplements such as GABA, and L-Tyrosine, and L-Phenylananine.
BERLIN – Lower rates of incident type 2 diabetes mellitus (T2DM) and improved glycemic control were two of the metabolic effects seen with the appetite-suppressant drug lorcaserin versus placebo on top of existing lifestyle management measures in a large-scale trial of more than 12,000 overweight or obese individuals with established cardiovascular disease or T2DM and other cardiovascular risk factors.Lorcaserin HCL
In the CAMELLIA-TIMI 61 trial, treatment with a twice-daily, 10-mg dose of lorcaserin for a median of 3.3 years was associated with a significant 19% reduction in the risk of incident T2DM in participants with prediabetes, compared with placebo (8.5% vs. 10.3%; hazard ratio, 0.81; 95% confidence interval, 0.66-0.99; P = .038). The reduction in the risk of incident T2DM was even greater (23%) in people without diabetes at baseline (6.7% lorcaserin vs. 8.4% placebo; HR, 0.77; 95% CI, 0.63-0.94; P = .012).
Furthermore, in patients with T2DM who had a mean baseline glycated hemoglobin (HbA1c) of 7%, an absolute 0.33% reduction was seen at 1 year between the lorcaserin and placebo groups, with more modest but still significant between-group reductions (–0.09% and –0.08%) in individuals with prediabetes or normoglycemia (all P less than .0001). When baseline HbA1c levels were higher in patients with T2DM (8%), greater net reductions (0.52%) versus placebo were seen (P less than .0001).
These were some of the metabolic findings, published online in the Lancet to coincide with their presentation at the annual meeting of the European Association for the Study of Diabetes, that add to those already released from the CAMELLIA-TIMI 61 trial on cardiovascular safety, lead author and TIMI (Thrombolysis in Myocardial Infarction) group investigator Erin A. Bohula May, MD, observed during a press conference.
The cardiovascular safety data were presented at the 2018 annual congress of the European Society for Cardiology in August and published in the New England Journal of Medicine. These showed no increase with lorcaserin versus placebo in the risk of achieving a major cardiovascular endpoint (MACE) of cardiovascular death, MI, or stroke (HR, 0.99; 95% CI, 0.85-1.14; P less than .001 for noninferiority). There was also no difference between groups in the cumulative incidence of MACE+, which included heart failure, hospitalization for unstable angina, and the need for coronary revascularization (HR, 0.97; 95% CI, 0.87-1.07; P = .55 for superiority).
“We know that weight loss can improve cardiovascular and glycemic risk factors, but it’s difficult to achieve and maintain, and weight-loss agents are guideline-recommended adjuncts to lifestyle modification,” said Dr. Bohula May, who is a cardiovascular medicine and critical care specialist at Brigham and Women’s Hospital in Boston.
“However, prior to this study no agent had convincingly demonstrated cardiovascular safety in a rigorous clinical outcomes study,” she said, noting that several agents, such as the now-withdrawn rimonabant (Acomplia/Zimulti) and sibutramine (Meridia), had been shown to precipitate cardiovascular or psychiatric events, which led the Food and Drug Administration to mandate that all weight-loss drugs be assessed for cardiovascular safety. Lorcaserin (Belviq) is a centrally acting 5-HT2C agonist that works by decreasing appetite and was approved by the FDA in 2012 but is not currently available in Europe.
Long-term data on the effects of weight-loss agents on glycemic parameters were limited, hence the remit of the CAMELLIA-TIMI 61 trial was to assess both the cardiovascular and metabolic safety of lorcaserin. The drug was used on a background of lifestyle modification in 6,000 obese or overweight individuals at high risk of cardiovascular events. A further 6,000 individuals received placebo.
Testosterone is the main male sex hormone, but females also have small amounts of it. It is a steroid hormone, produced in men’s testicles and women’s ovaries. During puberty in boys, testosterone is one of the main drivers of physical changes like increased muscle, deeper voice and hair growth.testosterone undecanoate powder
However, having optimal levels is also important throughout adulthood and even during old age. In adults, healthy levels are important for general health, disease risk, body composition, sexual function and just about everything else.
Additionally, increasing your testosterone levels can cause rapid gains in muscle mass and vitality in only a matter of weeks. Interestingly, it also plays an important role in female health and sexual well-being.
The research is pretty conclusive: both genders should ensure they have healthy levels of testosterone, especially as they age.
Here are 8 evidence-based ways to increase testosterone levels naturally.
1. Exercise and Lift Weights
Exercise is one of the most effective ways to prevent many lifestyle-related diseases. Interestingly, it can also boost your testosterone. A large review study found that people who exercised regularly had higher testosterone levels. In the elderly, exercise increases testosterone levels, fitness and reaction time. New research in obese men suggests that increased physical activity was even more beneficial than a weight loss diet for increasing testosterone levels. Resistance training, such as weight lifting, is the best type of exercise to boost testosterone in both the short- and long-term. High-intensity interval training (HIIT) can also be very effective, although all types of exercise should work to some extent. Taking caffeine and creatine monohydrate as supplements may further boost your levels when combined with a training program.
Bottom Line: All forms of exercise may increase your testosterone levels. Weight lifting and high-intensity interval training are the most effective.
2. Eat Protein, Fat and Carbs
What you eat has a major impact on testosterone as well as other hormone levels. Therefore, you must pay attention to your long-term calorie intake and diet strategy. Constant dieting or overeating may disrupt your testosterone levels. Eating enough protein can help maintain healthy levels and aid in fat loss, which is also associated with your testosterone. Carb intake also plays a role, with research showing carbs can help optimize testosterone levels during resistance training.
However, research demonstrates that sufficient healthy fats are also beneficial for testosterone and health. A diet based mainly on whole foods is best, with a healthy balance of fat, protein and carbs. This can optimize both hormone levels and long-term health.
Bottom Line: Don’t overeat and don’t restrict calories too much for too long. Try to eat balanced amounts of carbs, fat and protein.
3. Minimize Stress and Cortisol Levels
Research is always highlighting the dangers of long-term stress, which can elevate levels of the hormone cortisol. Unnatural elevations in cortisol can quickly reduce testosterone. These hormones work in a seesaw-like manner: as one goes up, the other comes down. Stress and high cortisol can also increase food intake, weight gain and the storage of harmful body fat around your organs. In turn, these changes may negatively impact your testosterone levels. For both optimal health and hormone levels, you should try to reduce repetitive stressful situations in your life. Focus on a diet based on whole foods, regular exercise, good sleep, laughter and a balanced lifestyle, all of which can reduce stress and improve your health and testosterone levels.
Bottom Line: High levels of stress are bad for your long-term health and can reduce your testosterone levels.
4. Get Some Sun or Take a Vitamin D Supplement
Vitamin D is quickly becoming one of the world’s most popular vitamins. Research has shown that it has various health benefits, and may also work as a natural testosterone booster. Despite its importance, nearly half of the US population is deficient in vitamin D, and an even higher percentage has sub-optimal levels.
A 12-month study found that supplementing with around 3,000 IU of vitamin D3 per day increased testosterone levels by around 25%. In the elderly, vitamin D and calcium also optimized testosterone levels, which led to a reduced risk of falling. To boost testosterone and reap the other benefits of vitamin D, try to get regular exposure to sunlight or take around 3,000 IU of a vitamin D3 supplement daily.
Bottom Line: Vitamin D3 supplements may boost testosterone levels, especially in the elderly and people who have low blood levels of vitamin D.
Testosterone levels in men have been linked to risks for cardiovascular disease, Parkinson's and even rheumatoid arthritis.testosterone powder
And Medical News Today recently reported on a study focusing on ancient skulls that suggested early humans' breakthrough in tool-making 50,000 years ago coincided with a lowering of testosterone levels in our species.
The researchers from this latest study, led by Justin Carré of Nipissing University in Canada, say previous studies found that administering a single dose of testosterone in subjects influenced brain circuit function, though these studies were - surprisingly - carried out in women.
To investigate testosterone's effects on the brain's threat response in men, the team recruited 16 healthy young male volunteers. Focusing on brain structures involved in threat processing and aggressive behavior, such as the amygdala, hypothalamus and periaqueductal gray, the researchers had the men complete 2 test days during which they received either a placebo or testosterone.
"Understanding testosterone's effects on the brain activity patterns associated with threat and aggression may help us better understand the 'fight or flight' response in males that may be relevant to aggression and anxiety," says Dr. John Krystal, editor of Biological Psychiatry.During the testing days, the men received a drug that suppressed their own testosterone so as to ensure that all study participants had similar levels for the study. As such, any men who received testosterone only received enough to return their levels to the normal range.
Next, the men underwent a functional magnetic resonance imaging (fMRI) scan while completing a face-matching task.
Dianabol powder is among the very few medicines that can also be prepared at home after mixing up a few raw materials. Once again, it is always good to consult a specialist before taking matters in your own hands. Some of the prominent ingredients needed to create the powder are, grapeseed oil, benzyl alcohol, methandrostenolone powder, ethyl oleate, benzyl benzoate and a few other items such as sterile glass vial, beaker, thermometer and syringe and a sterile syringe filter. After you’ve managed to arrange all these raw materials, the next step is to know your quantities. It is very important to know the portions in ml so that you can easily mix things up before they are ready to consume.
The U.S. Food and Drug Administration (FDA) cautions that prescription testosterone products are approved only for men who have low testosterone levels caused by certain medical conditions. The benefit and safety of these medications have not been established for the treatment of low testosterone levels due to aging, even if a man’s symptoms seem related to low testosterone. We are requiring that the manufacturers of all approved prescription testosterone products change their labeling to clarify the approved uses of these medications. We are also requiring these manufacturers to add information to the labeling about a possible increased risk of heart attacks and strokes in patients taking testosterone. Health care professionals should prescribe testosterone therapy only for men with low testosterone levels caused by certain medical conditions and confirmed by laboratory tests.Testosterone powder
Testosterone is FDA-approved as replacement therapy only for men who have low testosterone levels due to disorders of the testicles, pituitary gland, or brain that cause a condition called hypogonadism. Examples of these disorders include failure of the testicles to produce testosterone because of genetic problems, or damage from chemotherapy or infection. However, FDA has become aware that testosterone is being used extensively in attempts to relieve symptoms in men who have low testosterone for no apparent reason other than aging. The benefits and safety of this use have not been established.
In addition, based on the available evidence from published studies and expert input from an Advisory Committee meeting, FDA has concluded that there is a possible increased cardiovascular risk associated with testosterone use. These studies included aging men treated with testosterone. Some studies reported an increased risk of heart attack, stroke, or death associated with testosterone treatment, while others did not.
Based on our findings, we are requiring labeling changes for all prescription testosterone products to reflect the possible increased risk of heart attacks and strokes associated with testosterone use. Health care professionals should make patients aware of this possible risk when deciding whether to start or continue a patient on testosterone therapy. We are also requiring manufacturers of approved testosterone products to conduct a well-designed clinical trial to more clearly address the question of whether an increased risk of heart attack or stroke exists among users of these products. We are encouraging these manufacturers to work together on a clinical trial, but they are allowed to work separately if they so choose.
"This is the sort of multi-party collaboration that produces real results and can make a significant impact on the availability of counterfeit and illegal drugs used by some athletes globally," said Gunther Younger, intelligence director at WADA.
The operation stemmed from urine and blood tests carried out by WADA officials at various sports events, though the body did not specify when and where the tests were conducted.
Officials said some 1,000 individuals have since been reported for the production, use, and sale of performance-enhancing drugs, and 839 criminal cases have now been opened.WADA was influential in uncovering the complex trafficking system used to distribute the contraband drugs.
WADA said dealers used social media platforms to advertise their products. Non-professional athletes then used rechargeable credit cards and cryptocurrencies to purchase small amounts of the illicit drugs, which were distributed through gyms and online pharmacies.
The police operation, codenamed Viribus, was coordinated by Europol, led by Italy's Carabinieri and Greek police, and involved agents from Interpol, the Joint Research Center, and the European Anti-Fraud Office (OLAF).
Some 23 EU nations and 10 non-EU countries, including Colombia, Switzerland, and the United States, also participated in the operation that netted 3.8 million illegal medicines.The operation comes at a time when government agencies have taken a more active role in combating the scourge of performance-enhancing drugs in sports.
"Over the last 20 years, the worldwide trade in anabolic substances has increased significantly," Europol said.
Most recently, high-profile cases have included charges against Russian military intelligence officers in a case brought by the US Department of Justice, as well as accusations that the head of the international biathlon federation in Austria had covered up Russian doping.So many of the busts that have happened in the sports world for doping recently have only been possible because police have wiretapping ability and other investigative powers that normal anti-doping agencies and sports organizations don't have," said Max Cobb, president and CEO of the US Biathlon Association.
"We would like to congratulate all member states and other organizations that contributed to this successful operation," said WADA's Gunther Younger.
Basically, MUT is a four-step process:madden 20 coins
1. Acquire players
Who and what you pull from packs can drastically improve your team. Use the rewards and players from packs to take your Ultimate Team to the next level.
2. Earn coins
By completing Ultimate Challenges, and playing various modes like H2H Seasons and Squads, you can earn packs and coins to build your team.
3. Work the auction house
Bid on the players you want and post players for sale in the auction house.
4. Customize your team
Build your unique team of offensive, defensive, and special teams players, while choosing your favorite coaches playbooks and uniforms.
What's new in Madden Ultimate Team?
If you've already been playing MUT, then you'll want to know what's new once you launch "Madden 20."
EA Sports did a deep dive into all of the new MUT features, the biggest of which are Missions.Read More
As we originally discussed a couple months ago, player ratings in Madden 20 are going to be much more spread out than in previous years.nfl 20 madden coins
In the past, pretty much every starter in the game was rated in the mid 70s or higher. This year, there will be lower level starters and backups as low as 50-60 overall.
What this does is allows for superstar players to feel more like superstars. The elite players on your team will feel recognizably better than just an average starter. Before, that elite superstar might have only been about 10 points overall better than the average starter. Now, he will be somewhere around 15-20 points better.
The truly elite players in Madden 20 are staying basically the same. They’ll still be rated in the 90s. However, players rated below 90 overall are seeing ratings that will decrease by around 10-15%.
In last year’s game, 54% of players had ratings that were 70 OVR or higher. In Madden 20, only 41% of the players are at 70 OVR or higher.The chart below shows the number of players with certain overall ratings in Madden 20 compared to Madden 19.We put this data into chart form for better visualization which you can check out below.
As you can see, there really isn’t too much of a change up above 90 overall but as you get down into 60s, 70s and 80s there is a noticeable drop off.
One place where this new ratings spread is immediately noticeable is in quarterback throw power.
In Madden 19, over 50 quarterbacks had a throw power rating of 90 or better, with 80 being the absolute lowest. In Madden 20, only 18 quarterbacks have a 90 or higher throw power rating, with 72 being the lowest.Click Here
The FIFA 20 Ultimate Team Web app is nearly upon us as FIFA 20 momentum begins to pick up speed. For years, it’s been used to buy and sell players on the transfer market and build squads ahead of the game’s release. Recently the FIFA 20 closed beta started, with many getting to experience the game early, the rest will have to remain content will the flurry on information surrounding FIFA 20 Ultimate Team, FIFA 20 VOLTA Football and Buy FIFA 20 Coins Online.
The Web App can also be used to complete Squad Building Challenges
and keep track of your daily and weekly objectives. In short, it’s the
perfect way to get ahead on Ultimate Team.
This used to be the
epicentre of bragging rights regarding Ultimate Team, and EA need to do
more to regain the competitive nature between friends - not just across
the FIFA community.
You should also be able to complete daily challenges via the Web & Companion apps.Usually the daily objectives are simple whether it be applying a consumable or changing a kit. These could easily be achieved on users’ phones.
The benefits of this would mean players could do these more mundane tasks on the move and spend more time actuqally playing the game at home.We already know that Volta includes the ability to manage your squad, formation and play styles – so it’s certainly mobile friendly.
Elsewhere in the world of FIFA 20, the beta is landing imminently, giving a select few fans a chance to play EA Sports’ latest football game.
If you’re selected to participate in the FIFA 20 Closed Beta, EA will email you a code to play .
There’s no Closed Beta for PC or Nintendo Switch this year. Stay tuned for more information about the free trial, coming later this year.buy more mut 19 coins Click Here