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The analgesic activity of Torsemide is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Although Torsemide is known to exhibit a local anaesthetic effect, how Torsemide exerts this effect is not understood fully.
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muscle relaxers) while you are using Torsemide ; it may add to their effects.
Torsemide is well absorbed orally with an absolute bioavailability of 75%. Torsemide has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Torsemide and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Torsemide and M1, respectively.
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The effects of Torsemide and its metabolite mono-O-demethyl-Torsemide,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Torsemide and M1 occurs at two and three hours, respectively, after administration in healthy adults.
The effects of Torsemide and its metabolite mono-O-demethyl-Torsemide,
Torsemide may rarely be habit forming. Torsemide should be avoided in patients with a history.
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In vitro studies indicate that Torsemide is unlikely to inhibit,
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No effects on fertility were observed for Torsemide at oral dose levels up to 50 mg/kg,
We expected Torsemide to be equally effective as our current standard.
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whereas Torsemide 50 mg was statistically superior to placebo onlyfor remecation time.
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The analgesic activity of Torsemide is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
What is the addiction risk associated with Torsemide?
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The 6-hour TOTPAR scores for the Torsemide groups and ASA/,
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The product information for Torsemide states that convulsions have been reported in patients using Torsemide at the recommended dose levels and that the risk
Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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Torsemide may rarely be habit forming. Torsemide should be avoided in patients with a history.
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