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In general, both enantiomers of Colchicine and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
Colchicine is well absorbed orally with an absolute bioavailability of 75%. Colchicine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Colchicine is a centrally acting synthetic opioid analgesic.
Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Colchicine is rapidly and almost completely absorbed after oral administration.
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Intramuscular (i.m.) Colchicine increases gastric pH during anaesthesia similar to famotidine.
No effects on fertility were observed for Colchicine at oral dose levels up to 50 mg/kg,
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Colchicine is a centrally acting synthetic opioid analgesic.
How does Colchicine work? What will it do for me?Colchicine can cause side effects that may impair your thinking or reactions.
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Do not use this medication if you are allergic,
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