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The analgesic activity of Topamax is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Topamax had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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This effect may go away if you lie down forawile.
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The 6-hour TOTPAR scores for the Topamax groups and ASA/,
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Topamax should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Topamax may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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The binding of Topamax to human plasma proteins is approximately 20%,
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Nonetheless, Topamax nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Topamax is rapidly and almost completely absorbed after oral administration.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Topamax while you are pregnant.
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Topamax may not work as well and may require higher doses to obtain the same effect as when originally taken.
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Topamax can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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For Topamax, the following should be considered:The suitability of Topamax.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Topamax is used to relieve moderate to moderately severe pain.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Topamax may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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The effects of Topamax are similar to those of narcotic analgesics. Although Topamax is not classified as a narcotic, it may become habit-forming,
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Topamax has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
Topamax may not work as well and may require higher doses to obtain.
For Topamax, the following should be considered:The suitability of Topamax suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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