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In an open randomized trial, rectal Baclofen was compared with our standard treatment acetaminophen/codeine suppositories. We expected Baclofen to be equally effective as our current standard but with fewer side effects.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Baclofen and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Baclofen and M1, respectively.
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Baclofen may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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In general, both enantiomers of Baclofen and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
Baclofen is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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