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clinical trial was performed to assess the analgesic efficacy and reported side effects of Sinemet 100 mg, Sinemet 50 mg,
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Sinemet is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sinemet while you are pregnant.
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The analgesic activity of Sinemet is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Sinemet was what gave the Vedic gods their immortality. It was also a drink for mortals,
patients receiving Sinemet had a median gastric fluid pH of 6.4,
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Intramuscular (i.m.) Sinemet increases gastric pH during anaesthesia similar to famotidine.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Sinemet and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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