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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topiramate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topiramate and M1, respectively.
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Topiramate is administered as a racemate and both [-] and [+] forms of both Topiramate and M1 are detected in the circulation.
A single i.m. dose of Topiramate is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Topiramate had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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Topiramate may increase the seizure risk in patients taking other medications that lower the seizure threshold.
How does Topiramate work? What will it do for me?Topiramate can cause side effects that may impair your thinking or reactions.
adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Topiramate group.
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In general, both enantiomers of Topiramate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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