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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Metformin and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Metformin and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Metformin and M1, respectively.
risk of discontinuation due to adverse events associated with higher initial doses,
Metformin is administered as a racemate and both [-] and [+] forms of both Metformin and M1 are detected in the circulation.
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This is known as physical DEPENDENCE. If you suddenly stop taking Metformin , you may experience WITHDRAWAL symptoms including anxiety;
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