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Zyvox may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Breast-feeding�Zyvox passes into breast milk and may cause unwanted effects in nursing babies.
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IMPLICATIONS: The authors evaluated the effects of the analgesic Zyvox on the three major
Zyvox is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Zyvox and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Zyvox 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Zyvox is rapidly and almost completely absorbed after oral administration.
Zyvox may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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This is known as physical DEPENDENCE. If you suddenly stop taking Zyvox , you may experience WITHDRAWAL symptoms including anxiety;
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Check the label on the medicine for exact dosing instructions.Zyvox may cause drowsiness and dizziness.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Zyvox and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Zyvox has not been shown to cause histamine release. At therapeutic doses, Zyvox has no effect on heart rate, left-ventricular function or cardiac index.
tests indicates that Zyvox does not pose a genotoxic risk to humans.
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Zyvox may not work as well and may require higher doses to obtain.
The low numbers they quoted on Zyvox addiction and detoxification seem paltry in comparison
Zyvox was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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The analgesic activity of Zyvox is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Zyvox can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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These mechanisms may contribute independently to the overall analgesic profile of Zyvox.
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Zyvox may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Zyvox has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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