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Use Sominex with caution in the ELDERLY; they may be more sensitive to its effects.Sominex should not be used in CHILDREN younger than 16 years old;
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How does Sominex work? What will it do for me?Sominex can cause side effects that may impair your thinking or reactions.
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Although Sominex is known to exhibit a local anaesthetic effect, how Sominex exerts this effect is not understood fully.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Sominex may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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In an open randomized trial, rectal Sominex was compared with our standard treatment acetaminophen/codeine suppositories. We expected Sominex to be equally effective as our current standard but with fewer side effects.
For Sominex, the following should be considered:The suitability of Sominex suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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Sominex is well absorbed orally with an absolute bioavailability of 75%. Sominex has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Forty patients were treated with either Sominex suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Talk with your doctor if Sominex stops working well. Do not take more than prescribed.Some people who use Sominex for a long time without a break may develop a physical need to continue taking it.
In general, both enantiomers of Sominex and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Sominex has both opioid and monoaminergic agonist actions.
adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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Sominex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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