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Taking Estradiol together with medicines that are used during surgery or dental,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Estradiol is rapidly and almost completely absorbed after oral administration.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
The analgesic activity of Estradiol is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Estradiol and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Estradiol and M1, respectively.
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The product information for Estradiol states that convulsions have been reported in patients using Estradiol at the recommended dose levels and that the risk
These effects may be worse if you take it with alcohol or certain medicines. Use Estradiol with caution.
The suitability of Estradiol suppositories for inclusion in our hospital formulary,
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Ask your health care provider if Estradiol may interact with other medicines that you take.
Estradiol has not been shown to cause histamine release.
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Estradiol has not been shown to cause histamine release. At therapeutic doses, Estradiol has no effect on heart rate,
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the manufacturer-sponsored surveillance program's estimated rates of Estradiol abuse in a Estradiol-exposed population.
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There were no other significant respiratory diffences.
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The product information for Estradiol states that convulsions have been reported in patients using Estradiol at the recommended dose levels and that the risk
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These mechanisms may contribute independently to the overall analgesic profile of Estradiol.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Estradiol was evaluated in peri- and post-natal studies in rats.
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Estradiol may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Estradiol has not been shown to cause histamine release. At therapeutic doses, Estradiol has no effect on heart rate,
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