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In general, both enantiomers of Mestinon and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.

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Mestinon may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Mestinon may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Racemic Mestinon is rapidly and almost completely absorbed after oral administration.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Mestinon and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Mestinon and M1, respectively.
safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Mestinon has been shown to cause harm to the fetus.
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Mestinon is well absorbed orally with an absolute bioavailability of 75%. Mestinon has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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The effects of Mestinon are similar to those of narcotic analgesics. Although Mestinon is not classified as a narcotic, it may become habit-forming,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Mestinon and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Mestinon should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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