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In general, both enantiomers of Ketotifen and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The product information for Ketotifen states that convulsions have been reported in patients using Ketotifen at the recommended dose levels and that the risk
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The analgesic activity of Ketotifen is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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There were no other significant respiratory diffences.
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How does Ketotifen work? What will it do for me?Ketotifen can cause side effects that may impair your thinking or reactions.
Ketotifen is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Ketotifen and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Ketotifen and M1, respectively.
Ketotifen was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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The volume of distribution of Ketotifen was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Ketotifen has been shown to cause harm to the fetus.
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