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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topamax and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topamax and M1, respectively.
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Topamax is administered as a racemate and both [-] and [+] forms of both Topamax and M1 are detected in the circulation.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Topamax and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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the rates of withdrawals due to adverse events appeared to be higher in the Topamax groups.
Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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This is known as physical DEPENDENCE. If you suddenly stop taking Topamax , you may experience WITHDRAWAL symptoms including anxiety;
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If you suddenly stop taking Topamax , you may experience WITHDRAWAL symptoms including anxiety;
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Topamax may interact with other medicines that you take.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Topamax ; it may add to their effects.
The low numbers they quoted on Topamax addiction and detoxification seem paltry in comparison
For Topamax, the following should be considered:The suitability of Topamax.
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Forty patients were treated with either Topamax suppositories 100 mg 6 hourly.
Topamax may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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