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Ondansetron may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Ondansetron is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Forty patients were treated with either Ondansetron suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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In general, both enantiomers of Ondansetron and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Ondansetron had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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Ondansetron increases the risk of CNS and respiratory depression in these patients.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Ondansetron has been shown to cause harm to the fetus.
Ondansetron may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Ondansetron has not been shown to cause histamine release. At therapeutic doses, Ondansetron has no effect on heart rate, left-ventricular function or cardiac index.
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Ondansetron can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
Ondansetron may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Nonetheless, Ondansetron nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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Respiratory depression should be treated as an overdose.
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Use Ondansetron with caution in the ELDERLY; they may be more sensitive to its effects.Ondansetron should not be used in CHILDREN younger than 16 years old;
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This indicates that Ondansetron slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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The product information for Ondansetron states that convulsions have been reported in patients using Ondansetron at the recommended dose levels and that the risk
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Ondansetron was not mutagenic in the following assays:
Ondansetron was evaluated in peri- and post-natal studies in rats.
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Ondansetron may rarely be habit forming. Ondansetron should be avoided in patients with a history.
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Forty patients were treated with either Ondansetron suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Ondansetron has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
The effects of Ondansetron and its metabolite mono-O-demethyl-Ondansetron,
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Check the label on the medicine for exact dosing instructions.Ondansetron may cause drowsiness and dizziness.
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Ondansetron may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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