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Zyban is well absorbed orally with an absolute bioavailability of 75%. Zyban has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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The volume of distribution of Zyban was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Zyban and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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