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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Imuran and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Imuran and M1, respectively.
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Imuran is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.

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Use Imuran with caution in the ELDERLY; they may be more sensitive to its effects.Imuran should not be used in CHILDREN younger than 16 years old;
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Imuran has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Imuran had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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Imuran has not been shown to cause histamine release. At therapeutic doses, Imuran has no effect on heart rate, left-ventricular function or cardiac index.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Imuran and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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