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Hydroxyurea has not been shown to cause histamine release. At therapeutic doses, Hydroxyurea has no effect on heart rate,
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Hydroxyurea and M1 elimination half-lives (13 hrs. for Hydroxyurea and 19 hrs. for M1).
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Nonetheless, Hydroxyurea nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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Hydroxyurea is well absorbed orally with an absolute bioavailability of 75%. Hydroxyurea has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Hydroxyurea and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Hydroxyurea and M1, respectively.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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