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The analgesic activity of Methotrexate is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Methotrexate is administered as a racemate and both [-] and [+] forms of both Methotrexate and M1 are detected in the circulation.
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Methotrexate is found in breast milk. Do not breast-feed while taking Methotrexate .When used for long periods of time or at high doses,
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Methotrexate may interact with other medicines that you take.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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In general, both enantiomers of Methotrexate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
For Methotrexate, the following should be considered:The suitability of Methotrexate.
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