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In general, both enantiomers of Estradiol and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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In general, both enantiomers of Estradiol and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Estradiol and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Estradiol and M1, respectively.
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Do not drive or perform other possibly unsafe tasks until you know how you react to it.Do not drink
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The volume of distribution of Estradiol was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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Estradiol is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Estradiol may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Estradiol may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Breast-feeding�Estradiol passes into breast milk and may cause unwanted effects in nursing babies.
Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Estradiol is rapidly and almost completely absorbed after oral administration.
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This is known as physical DEPENDENCE. If you suddenly stop taking Estradiol , you may experience WITHDRAWAL symptoms including anxiety;
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Estradiol has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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