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Nexium is a centrally acting synthetic opioid analgesic.
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Intramuscular (i.m.) Nexium increases gastric pH during anaesthesia similar to famotidine.
Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Nexium group.
In vitro studies indicate that Nexium is unlikely to inhibit,
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Nexium may increase the seizure risk in patients taking other medications that lower the seizure threshold.
This indicates that Nexium slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Use Nexium with caution in the ELDERLY; they may be more sensitive to its effects.Nexium should not be used in CHILDREN younger than 16 years old;
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Respiratory depression should be treated as an overdose.
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Nexium and M1 elimination half-lives (13 hrs. for Nexium and 19 hrs. for M1).
We investigated the antacid analgesic value of a single dose of i.m. Nexium given 1 h before elective ,
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Nexium has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Nexium and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Nexium and M1, respectively.
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Racemic Nexium is rapidly and almost completely absorbed after oral administration.
Nexium is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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The volume of distribution of Nexium was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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Tell your doctor or dentist that you take Nexium before you receive any medical or dental care, emergency care, or surgery.
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