Palmitoylethanolamide is a fatty acid amide that is naturally present in our bodies. It mainly functions as a very comprehensive anti-inflammatory and pain reducer. In terms of pain reduction, it works great for individuals with neuropathic pain and produces significant back pain relief and sciatic pain relief. This is due to the fact that palmitoylethanolamide produces something called the ‘Entourage Effect’ an effect which potentiates the effects of Anandamide and it is naturally present in our bodies. Anandamide plays a crucial role in inflammation and pain perception, and Palmitoylethanolamide prevents the breakdown of anandamide and works to enhance its effects in the body. This pathway is especially effective at decreasing neuropathic pain and thus palmitoylethanolamide is very popular with people looking for sciatic pain relief and back pain relief.Palmitoylethanolamide

Palmitoylethanolamide also works to decrease inflammation by interacting with an enzyme called cyclooxygenase 2 (COX-2). This enzyme produces inflammation and is the target of most NSAIDs like Ibuprofen. These NSAIDs decrease pain perception by blocking COX-2 activity, whereas palmitoylethanolamide decreases pain perception by preventing the production of proinflammatory compounds that are produced by COX-2, such as prostaglandins D2 and E2.

Another unique effect that palmitoylethanolamide has, is that it activates the PPAR-alpha receptor. This receptor a major mediator of inflammation and pain perception and its activation causes a decrease in inflammation and a subsequent drop in pain perception.

Altogether, palmitoylethanolamide is a great compound for neuropathic pain and is a fantastic choice for individuals looking for sciatic pain relief and back pain relief.

*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Palmitoylethanolamide, also known as PEA, is a endogenous fatty acid amide that has been demonstrated to exert a great variety of biological functions related to pain. Additionally, it has been shown to have neuroprotective properties. Pain management support dates as far back as before 1980. The birth of the molecule was in 1957 and it was in that year that 5 researchers believed that PEA was a natural pain management supplement.