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Topiramate is quickly absorbed after oral use. Most of the drug (70%) is excreted in the urine unchanged. The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose. Take topiramate exactly as your doctor tells you to. It is usual to start topiramate treatment on a low dose (25 mg at night), and then for the dose to be increased gradually. A usual maintenance dose is 50-100 mg daily, taken either as a single dose or divided into two doses over the day. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions).

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