Premature ejaculation (PE) is one of the most common male sexual dysfunction, which has a great impact on self-esteem and marital relationship. Tricyclic antidepressants and clomipramine are the most widely used drugs in the treatment of premature ejaculation, in addition to adrenergic receptor antagonists, benzodiazepine drugs, gabapentin and so on. Serotonin reuptake inhibitors are the most widely used, effective and fast-developing drugs for premature ejaculation.Oral Tbol powder
Dapoxetine, chemically known as (S) - (+) - N, N-dimethyl-3 - (nitro-1-oxy) - 1-amphetamin, is a novel 5-hydroxytryptamine reuptake inhibitor, a water-soluble white or gray-white powder with a chemical structure similar to the antidepressant fluoxetine and the only halogen-free 5-hydroxytryptamine reuptake inhibitor. Agent. Central neurotransmitters 5-HT, dopamine and their receptors play an important role in ejaculation regulation. Dapoxetine can effectively inhibit 5-HT reuptake, increase 5-HT concentration in synaptic spaces, activate 5-HT2C and 5-HT1A receptors in postsynaptic membranes, and delay ejaculation by inhibiting 5-HT transporters. Symptoms of premature ejaculation in men. Compared with other serotonin reuptake inhibitors, Dapoxetine has the advantages of good efficacy, short half-life and fewer side effects.
Dapoxetine promotes delayed ejaculation by inhibiting serotonin transporter and increasing the role of serotonin in the postsynaptic cleft. As a member of the selective serotonin reuptake inhibitor (SSRI) family, Dapoxetine was originally produced as an antidepressant. However, unlike other SSRI, dpooxetine is rapidly absorbed and eliminated in vivo. Its fast action makes it suitable for the treatment of premature ejaculation (PE).