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This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthroid may interact with other medicines that you take.
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Synthroid has not been shown to cause histamine release. At therapeutic doses, Synthroid has no effect on heart rate,
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Synthroid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
Taking Synthroid together with medicines that are used during surgery or dental,
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Synthroid may interact with other medicines that you take.
Synthroid is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Synthroid is found in breast milk. Do not breast-feed while taking Synthroid .When used for long periods of time or at high doses,
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It is slightly soluble in water and freely soluble in alcohol,
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Synthroid has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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whereas Synthroid 50 mg was statistically superior to placebo onlyfor remecation time.
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The effects of Synthroid are similar to those of narcotic analgesics. Although Synthroid is not classified as a narcotic, it may become habit-forming,
more potent than Synthroid in producing analgesia and 200 times more potent in ?-opioid binding.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Synthroid and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Synthroid and M1, respectively.
If you suddenly stop taking Synthroid , you may experience WITHDRAWAL symptoms including anxiety;
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A single i.m. dose of Synthroid is useful pre-treatment to minimize the risk of acid aspiration during operation,
Synthroid has not been shown to cause histamine release. At therapeutic doses, Synthroid has no effect on heart rate, left-ventricular function or cardiac index.
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