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You may not be able to take Warfarin, or you may require a dosage adjustment,
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For Warfarin, the following should be considered:The suitability of Warfarin.
If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Warfarin while you are pregnant.
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It is slightly soluble in water and freely soluble in alcohol,
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Warfarin group.
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risk of discontinuation due to adverse events associated with higher initial doses,
The effects of Warfarin and its metabolite mono-O-demethyl-Warfarin,
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Intramuscular (i.m.) Warfarin increases gastric pH during anaesthesia similar to famotidine.
Warfarin is well absorbed orally with an absolute bioavailability of 75%. Warfarin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Warfarin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Warfarin is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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These mechanisms may contribute independently to the overall analgesic profile of Warfarin.
Warfarin is found in breast milk. Do not breast-feed while taking Warfarin .When used for long periods of time or at high doses,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Warfarin and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Warfarin increases the risk of CNS and respiratory depression in these patients.
Warfarin may not work as well and may require higher doses to obtain the same effect as when originally taken.
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A single i.m. dose of Warfarin is useful pre-treatment to minimize the risk of acid aspiration during operation,
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