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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Methotrexate has been shown to cause harm to the fetus.
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In general, both enantiomers of Methotrexate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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