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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Topiramate group.
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In general, both enantiomers of Topiramate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Topiramate has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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