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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Imitrex and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Imitrex is a centrally acting synthetic opioid analgesic.
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Imitrex is associated with craving and tolerance development.
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For Imitrex, the following should be considered:The suitability of Imitrex.
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Imitrex has both opioid and monoaminergic agonist actions.
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Talk with your doctor if Imitrex stops working well. Do not take more than prescribed.Some people who use Imitrex for a long time without a break may develop a physical need to continue taking it.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Imitrex may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Forty patients were treated with either Imitrex suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
Imitrex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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In general, both enantiomers of Imitrex and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
We expected Imitrex to be equally effective as our current standard.
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Imitrex is rapidly and almost completely absorbed after oral administration.

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Imitrex may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
Imitrex may rarely be habit forming. Imitrex should be avoided in patients with a history.
In general, both enantiomers of Imitrex and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Imitrex and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Imitrex and M1, respectively.


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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Imitrex ; it may add to their effects.

alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Imitrex ; it may add to their effects.
These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex with caution.
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