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Januvia may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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These mechanisms may contribute independently to the overall analgesic profile of Januvia.
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Forty patients were treated with either Januvia suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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The binding of Januvia to human plasma proteins is approximately 20%,
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Januvia can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
Januvia can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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Racemic Januvia is rapidly and almost completely absorbed after oral administration.
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Check the label on the medicine for exact dosing instructions.Januvia may cause drowsiness and dizziness.
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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Nonetheless, Januvia nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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If you suddenly stop taking Januvia , you may experience WITHDRAWAL symptoms including anxiety;
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muscle relaxers) while you are using Januvia ; it may add to their effects.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Januvia is well absorbed orally with an absolute bioavailability of 75%. Januvia has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
Januvia and M1 elimination half-lives (13 hrs. for Januvia and 19 hrs. for M1).
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We investigated the antacid analgesic value of a single dose of i.m. Januvia given 1 h before elective ,
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Januvia may interact with other medicines that you take.
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For Januvia, the following should be considered:The suitability of Januvia.
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Breast-feeding�Januvia passes into breast milk and may cause unwanted effects in nursing babies.
Januvia has not been shown to cause histamine release. At therapeutic doses, Januvia has no effect on heart rate, left-ventricular function or cardiac index.
Check with your health care provider before you start, stop, or change the dose of any medicine.Use Januvia as directed by your doctor.
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Breast-feeding�Januvia passes into breast milk and may cause unwanted effects in nursing babies.
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Januvia is used to relieve moderate to moderately severe pain.
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causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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Do not drive or perform other possibly unsafe tasks until you know how you react to it.Do not drink
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