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Bisacodyl may rarely be habit forming. Bisacodyl should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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the rates of withdrawals due to adverse events appeared to be higher in the Bisacodyl groups.
Bisacodyl may not work as well and may require higher doses to obtain the same effect as when originally taken.
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This indicates that Bisacodyl slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Bisacodyl and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Bisacodyl and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Bisacodyl and M1, respectively.
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Bisacodyl and M1 elimination half-lives (13 hrs. for Bisacodyl and 19 hrs. for M1).
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Bisacodyl has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Bisacodyl has been shown to cause harm to the fetus.
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The volume of distribution of Bisacodyl was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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Check the label on the medicine for exact dosing instructions.Bisacodyl may cause drowsiness and dizziness.
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This is known as physical DEPENDENCE. If you suddenly stop taking Bisacodyl , you may experience WITHDRAWAL symptoms including anxiety;
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
Bisacodyl may rarely be habit forming. Bisacodyl should be avoided in patients with a history.
Prepare for the withdrawal symptoms of discontinued Bisacodyl use.
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Bisacodyl is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Bisacodyl may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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