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The volume of distribution of Hydroxyurea was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
Ask your pharmacist if you have questions about which medicines may cause drowsiness.Hydroxyurea may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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In general, both enantiomers of Hydroxyurea and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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In general, both enantiomers of Hydroxyurea and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Do not drive or perform other possibly unsafe tasks until you know how you react to it.Do not drink
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clinical trial was performed to assess the analgesic efficacy and reported side effects of Hydroxyurea 100 mg, Hydroxyurea 50 mg,
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The analgesic activity of Hydroxyurea is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
Some people who use Hydroxyurea for a long time without a break may develop a physical need to continue taking it.
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The volume of distribution of Hydroxyurea was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
Hydroxyurea is well absorbed orally with an absolute bioavailability of 75%. Hydroxyurea has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
patients receiving Hydroxyurea had a median gastric fluid pH of 6.4,
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Hydroxyurea has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Hydroxyurea has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Hydroxyurea is rapidly and almost completely absorbed after oral administration.
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