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In general, both enantiomers of Topiramate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The binding of Topiramate to human plasma proteins is approximately 20%,
Topiramate was evaluated in peri- and post-natal studies in rats.
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IMPLICATIONS: The authors evaluated the effects of the analgesic Topiramate on the three major
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topiramate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topiramate and M1, respectively.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topiramate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topiramate and M1, respectively.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topiramate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topiramate and M1, respectively.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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The volume of distribution of Topiramate was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
Topiramate is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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In an open randomized trial, rectal Topiramate was compared with our standard treatment acetaminophen/codeine suppositories. We expected Topiramate to be equally effective as our current standard but with fewer side effects.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Topiramate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Topiramate and M1, respectively.
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In general, both enantiomers of Topiramate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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