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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Methotrexate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Methotrexate and M1, respectively.

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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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