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Buspirone has not been shown to cause histamine release. At therapeutic doses, Buspirone has no effect on heart rate,
It is slightly soluble in water and freely soluble in alcohol,
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This is known as physical DEPENDENCE. If you suddenly stop taking Buspirone , you may experience WITHDRAWAL symptoms including anxiety;
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Buspirone can impair thinking and the physical abilities required for driving or operating machinery. Buspirone should be avoided in patients intoxicated with alcohol,
You may not be able to take Buspirone, or you may require a dosage adjustment,
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Check the label on the medicine for exact dosing instructions.Buspirone may cause drowsiness and dizziness.
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Buspirone is well absorbed orally with an absolute bioavailability of 75%. Buspirone has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
Use Buspirone with caution in the ELDERLY; they may be more sensitive to its effects.Buspirone should not be used in CHILDREN younger than 16 years old;
Buspirone is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Buspirone may interact with other medicines that you take.
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Buspirone may rarely be habit forming. Buspirone should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Buspirone and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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In general, both enantiomers of Buspirone and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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