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Intramuscular (i.m.) Imuran increases gastric pH during anaesthesia similar to famotidine.
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In an open randomized trial, rectal Imuran was compared with our standard treatment acetaminophen/codeine suppositories. We expected Imuran to be equally effective as our current standard but with fewer side effects.
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Imuran is well absorbed orally with an absolute bioavailability of 75%. Imuran has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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the drug are not limited to those patients with prior history of opioid dependence.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Imuran may interact with other medicines that you take.
Intramuscular (i.m.) Imuran increases gastric pH during anaesthesia similar to famotidine.
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Breast-feeding�Imuran passes into breast milk and may cause unwanted effects in nursing babies.
adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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The analgesic activity of Imuran is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Imuran is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
The volume of distribution of Imuran was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
patients receiving Imuran had a median gastric fluid pH of 6.4,
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In general, both enantiomers of Imuran and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Imuran had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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Imuran increases the risk of CNS and respiratory depression in these patients.
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The product information for Imuran states that convulsions have been reported in patients using Imuran at the recommended dose levels and that the risk
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